Core D: Environmental Assessment Core

核心 D：环境评估核心

• 批准号: 10440337
• 负责人: Kyle D Crowder
• 金额: $ 13.06万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440337
• 关键词: Aging; Air; Air Pollution; Behavior; Canis familiaris; Censuses; Chronic Disease; Companions; Crowding; Data; Data Analyses; Data Analytics; Data Sources; Development; Diet; Environment; Environmental Exposure; Genes; Genetic; Geographic Information Systems; Goals; Health; Health behavior; Household; Individual; Inflammaging; Inherited; Joints; Location; Longevity; Malignant Neoplasms; Measurement; Measures; Methods; Modeling; Molecular; Nature; Pharmaceutical Preparations; Phenotype; Physical activity; Population Density; Process; Questionnaires; Recording of previous events; Research; Research Personnel; Research Project Grants; Risk Factors; Role; Services; Social Conditions; Social Environment; Specialist; Statistical Models; Surveys; Testing; Travel; United States Environmental Protection Agency; Variant; Water Pollution; Weather; Work; base; behavioral health; cohort; comorbidity; design; epigenome; experience; feeding; frailty; healthspan; healthy aging; metabolome; microbiome; mortality; reproductive; water quality

CORE D – ENVIRONMENTAL ASSESSMENT CORE PROJECT SUMMARY The goals of the Dog Aging Project are to create a cohort of 10,000 companion dogs through which it will become possible to identify the genetic and environmental determinants of healthy aging, discover the underlying mechanisms through which genes and environment influence aging, and test a highly promising drug for its ability to increase lifespan and healthspan. Given that the majority of variation in aging phenotypes within mammalian species is likely to be explained by differences in environmental exposures – either alone or via interactions with inherited genetic factors – measurement of environmental variables for each dog in the cohort is essential. In order to meet the needs of the scientific projects for coordinated expertise in determining which aspects of the environment should and can be characterized, and through which approaches, an Environmental Assessment Core (EAC) will be established. The overall goal of the EAC is to support the scientific aims of the research projects by developing and implementing strategies for acquiring data that characterize various aspects of the companion dog environment. Specific aims of this Core are to: 1) Design and implement annual dog owner-administered questionnaires that elicit each dog's travel history, non- prescription medications, diet and feeding, household environment, physical activity, reproductive activity, and behavior, as well as key behavioral and health conditions for owners; 2) Collect, process, validate, and prepare primary and secondary data related to conditions of the dog's environment; and, 3) Collaborate with Project Investigators to develop analytic strategies to assess the role of environmental conditions, and their interactions with genetic factors, in processes of aging.

核心D -环境评估核心 项目摘要 狗老化项目的目标是建立一个由10,000只伴侣狗组成的队列， 有可能确定健康老龄化的遗传和环境决定因素，发现 基因和环境影响衰老的潜在机制，并测试了一个非常有前途的 它能延长人的寿命和健康。考虑到衰老表型中的大多数变异 在哺乳动物物种中，可能是由环境暴露的差异来解释的-单独或 通过与遗传遗传因素的相互作用-测量中每只狗的环境变量 cohort是必不可少的为了满足科学项目在确定 环境的哪些方面应该和可以被描述，以及通过哪些方法， 将建立环境评估核心（EAC）。选管会的整体目标是支持 通过制定和实施获取数据的战略， 描述了伴侣犬环境的各个方面。本核心的具体目标是：1）设计 并实施年度狗主人管理的问卷调查，以了解每只狗的旅行史，非 处方药、饮食和喂养、家庭环境、体力活动、生殖活动，以及 行为，以及业主的关键行为和健康状况; 2）收集，处理，验证和准备 与狗的环境条件相关的主要和次要数据;以及，3）与项目合作 研究人员制定分析战略，以评估环境条件的作用， 在衰老过程中与遗传因素的相互作用。