Viral Testing

病毒检测

• 批准号: 10447031
• 负责人: CARLOS A SARIOL
• 金额: $ 82.18万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447031
• 关键词: AIDS/HIV problem; Adolescent; Algorithms; Animals; Biochemistry; Biological Assay; Biological Markers; Biological Models; Biological Sciences; Biomedical Research; Breeding; Caribbean region; Caring; Cercopithecine Herpesvirus 1; Collaborations; Communities; Data; Disease; Funding; Genetic; Geographic Locations; Goals; HIV; Human; Human Resources; Individual; Institution; International; Intuition; Island; Macaca mulatta; Maintenance; Medical; Methodology; Modeling; Modification; Monkeys; Occupational Health; Peer Group; Physiology; Primates; Protocols documentation; Research; Resources; Risk; SIV; STLV-3; Safety; Science; Simian Retroviruses; Source; Testing; United States National Institutes of Health; Viral; Virus; animal colony; arm; base; diagnostic algorithm; driving force; germ free condition; improved; nonhuman primate; operation; programs; research and development; therapeutic development; virology

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to sustain the Specific Pathogen Free (SPF) program at the Caribbean Primate Research Center's (CPRC) through support of operations, administration, veterinary care, virological and MHC typing and by the improvement of our comprehensive genetic management plan. A unique feature of CPRC animals in favoring a successful establishment and sustainable of SPF colony are that these animals are naturally free of SIV and SRV-D, two of the four viruses to be tested for. Nevertheless, for safety and as required for the SPF Program, we continue systematically testing for all four viruses (B virus, STLV, SIV and SRV-D). The Program provides unadmixed Indian-origin rhesus monkeys with defined genetic and virological background. The primary purpose of the virology testing arm of CPRC-SPF breeding program is to assure that its Indian- origin rhesus macaque colony, supporting NIH-sponsored research specially on HIV/AIDS, is free of the above- mentioned viruses. An advantage of this program is that it has been closed to external individuals since 2015. Certainly, this aspect substantially decreases the risks of the re-introduction of any of the four tested viruses from an external source.

项目摘要/摘要： 该应用程序的主要目标是在加勒比海地区维持无特定病原体(SPF)计划 灵长类动物研究中心(CPRC)通过运营、管理、兽医护理、病毒学支持 和MHC分型，以及我们全面遗传管理计划的改进。的一个独特功能 CPRC动物在支持SPF殖民地的成功建立和可持续方面是这些动物 自然不含SIV和SRV-D，这是四种待检测病毒中的两种。尽管如此，为了安全和按要求 对于SPF计划，我们继续对所有四种病毒(B病毒、STLV、SIV和SRV-D)进行系统测试。这个 该计划为纯印度血统的恒河猴提供明确的遗传和病毒学背景。 CPRC-SPF育种计划的病毒学检测部门的主要目的是确保其印度- 原产地恒河猴群体，支持NIH赞助的专门针对艾滋病毒/艾滋病的研究，不存在上述- 提到了病毒。这项计划的一个好处是，自2015年以来一直对外部个人关闭。 当然，这方面大大降低了四种测试病毒中任何一种从 外部消息来源。