Viral Testing

病毒检测

• 批准号: 10447031
• 负责人: CARLOS A SARIOL
• 金额: $ 82.18万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447031
• 关键词: AIDS/HIV problem; Adolescent; Algorithms; Animals; Biochemistry; Biological Assay; Biological Markers; Biological Models; Biological Sciences; Biomedical Research; Breeding; Caribbean region; Caring; Cercopithecine Herpesvirus 1; Collaborations; Communities; Data; Disease; Funding; Genetic; Geographic Locations; Goals; HIV; Human; Human Resources; Individual; Institution; International; Intuition; Island; Macaca mulatta; Maintenance; Medical; Methodology; Modeling; Modification; Monkeys; Occupational Health; Peer Group; Physiology; Primates; Protocols documentation; Research; Resources; Risk; SIV; STLV-3; Safety; Science; Simian Retroviruses; Source; Testing; United States National Institutes of Health; Viral; Virus; animal colony; arm; base; diagnostic algorithm; driving force; germ free condition; improved; nonhuman primate; operation; programs; research and development; therapeutic development; virology

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to sustain the Specific Pathogen Free (SPF) program at the Caribbean Primate Research Center's (CPRC) through support of operations, administration, veterinary care, virological and MHC typing and by the improvement of our comprehensive genetic management plan. A unique feature of CPRC animals in favoring a successful establishment and sustainable of SPF colony are that these animals are naturally free of SIV and SRV-D, two of the four viruses to be tested for. Nevertheless, for safety and as required for the SPF Program, we continue systematically testing for all four viruses (B virus, STLV, SIV and SRV-D). The Program provides unadmixed Indian-origin rhesus monkeys with defined genetic and virological background. The primary purpose of the virology testing arm of CPRC-SPF breeding program is to assure that its Indian- origin rhesus macaque colony, supporting NIH-sponsored research specially on HIV/AIDS, is free of the above- mentioned viruses. An advantage of this program is that it has been closed to external individuals since 2015. Certainly, this aspect substantially decreases the risks of the re-introduction of any of the four tested viruses from an external source.

项目总结/文摘: