Viral Testing

项目总结/摘要： 这项申请的主要目标是维持加勒比地区的无特定病原体（SPF）计划 灵长类动物研究中心（CPRC）通过支持运营，管理，兽医护理，病毒学 和MHC分型，并通过改进我们的综合遗传管理计划。的独特特征 CPRC动物有利于成功建立和可持续的SPF群体，这些动物是 天然不含SIV和SRV-D，这是四种待检测病毒中的两种。然而，为了安全和需要， 对于SPF计划，我们继续系统地检测所有四种病毒（B病毒、STLV、SIV和SRV-D）。的 计划提供具有明确遗传和病毒学背景的印度恒河猴。 CPRC-SPF育种计划的病毒学测试部门的主要目的是确保其印度- 支持NIH赞助的艾滋病毒/艾滋病研究的原产地恒河猴群不存在上述问题- 提到病毒。该计划的一个优点是，自2015年以来，它一直对外部个人关闭。 当然，这方面大大降低了四种测试病毒中任何一种从 外部来源。

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to sustain the Specific Pathogen Free (SPF) program at the Caribbean Primate Research Center's (CPRC) through support of operations, administration, veterinary care, virological and MHC typing and by the improvement of our comprehensive genetic management plan. A unique feature of CPRC animals in favoring a successful establishment and sustainable of SPF colony are that these animals are naturally free of SIV and SRV-D, two of the four viruses to be tested for. Nevertheless, for safety and as required for the SPF Program, we continue systematically testing for all four viruses (B virus, STLV, SIV and SRV-D). The Program provides unadmixed Indian-origin rhesus monkeys with defined genetic and virological background. The primary purpose of the virology testing arm of CPRC-SPF breeding program is to assure that its Indian- origin rhesus macaque colony, supporting NIH-sponsored research specially on HIV/AIDS, is free of the above- mentioned viruses. An advantage of this program is that it has been closed to external individuals since 2015. Certainly, this aspect substantially decreases the risks of the re-introduction of any of the four tested viruses from an external source.