Viral Testing

病毒检测

• 批准号: 10647888
• 负责人: CARLOS A SARIOL
• 金额: $ 82.18万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10647888
• 关键词: Adolescent; Algorithms; Animals; Biochemistry; Biological Assay; Biological Markers; Biological Models; Biological Sciences; Biomedical Research; Breeding; Caribbean region; Caring; Collaborations; Communities; Data; Disease; Funding; Genetic; Geographic Locations; Goals; HIV; HIV/AIDS; Human; Human Resources; Individual; Institution; International; Intuition; Island; Macaca mulatta; Maintenance; Medical; Methodology; Modeling; Modification; Monkeys; Occupational Health; Peer Group; Physiology; Primates; Protocols documentation; Research; Resources; Risk; SIV; STLV-3; Safety; Science; Simian Retroviruses; Source; Testing; United States National Institutes of Health; Viral; Virus; arm; diagnostic algorithm; driving force; germ free condition; improved; nonhuman primate; operation; programs; research and development; therapeutic development; virology

PROJECT SUMMARY/ABSTRACT: The major goal of this application is to sustain the Specific Pathogen Free (SPF) program at the Caribbean Primate Research Center's (CPRC) through support of operations, administration, veterinary care, virological and MHC typing and by the improvement of our comprehensive genetic management plan. A unique feature of CPRC animals in favoring a successful establishment and sustainable of SPF colony are that these animals are naturally free of SIV and SRV-D, two of the four viruses to be tested for. Nevertheless, for safety and as required for the SPF Program, we continue systematically testing for all four viruses (B virus, STLV, SIV and SRV-D). The Program provides unadmixed Indian-origin rhesus monkeys with defined genetic and virological background. The primary purpose of the virology testing arm of CPRC-SPF breeding program is to assure that its Indian- origin rhesus macaque colony, supporting NIH-sponsored research specially on HIV/AIDS, is free of the above- mentioned viruses. An advantage of this program is that it has been closed to external individuals since 2015. Certainly, this aspect substantially decreases the risks of the re-introduction of any of the four tested viruses from an external source.

项目摘要/摘要： 该应用的主要目的是维持加勒比海的特定病原体（SPF）计划 灵长类动物研究中心（CPRC）通过支持操作，管理，兽医，病毒学 和MHC打字，并通过改进我们的全面遗传管理计划。一个独特的功能 CPRC动物有利于成功建立和可持续的SPF殖民地的动物是这些动物是 自然没有SIV和SRV-D，这是要测试的四种病毒中的两种。然而，出于安全和要求 对于SPF计划，我们继续系统地测试所有四种病毒（B病毒，STLV，SIV和SRV-D）。这 计划提供具有固定的遗传和病毒学背景的无混合的印度王朝恒河猴子。 CPRC-SPF育种计划的病毒学测试部门的主要目的是确保其印度 原产质猕猴的殖民地，专门支持NIH赞助的艾滋病毒/艾滋病研究，没有上述 提到的病毒。该计划的一个优点是，自2015年以来，它已经对外部个人关闭。 当然，这方面大大降低了从 外部来源。