Catalytic C-C Activation of Ketones - Renewal 01

酮的催化 C-C 活化 - 更新 01

• 批准号: 10447204
• 负责人: Guangbin Dong
• 金额: $ 30.52万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10447204
• 关键词: Carbon; Catalysis; Chemicals; Chemistry; Cobalt; Complex; Funding; Goals; Hydrogen Bonding; Indole Alkaloids; Ketones; Laboratories; Mediating; Methods; Natural Product Drug; Oxidation-Reduction; Process; Research; Skeleton; Structure; Surface; System; Transition Elements; Work; analog; bioactive natural products; carbon skeleton; catalyst; cofactor; functional group; interest; novel; public health relevance; small molecule; success

Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C) bond activation for developing new, general and synthetically useful methods. Our objective, in the proposed funding period, is to focus on C−C activation of ketones, as ketone moieties are ubiquitously found in feedstock chemicals, synthetic building blocks and bioactive compounds. Specifically, we will: (i) expand the scope and utilities with activation of strained ketones for constructing complex ring systems, (ii) enable new and broadly applicable transformations with unstrained ketones in an atom-economical fashion, and (iii) explore a new activation mode that can shift the paradigm for ketone activation. The research proposed is expected to simplify synthesis through new strategic bond disconnections, allow for editing skeletons of complex molecules under redox-neutral conditions, and offer a byproduct-free approach to access organic building blocks.

摘要：我们正在系统地开发催化碳-碳（C−C）