New Directions in Palladium/Norbornene Cooperative-Renewal

摘要：我们致力于系统地开发新的、高效的和广泛有用的产品。 钯/降冰片烯(Pd/NBE)催化定点芳烃/杂芳烃邻位二元反应 官能化和一步法羰基1，2-转座。我们建议拨款的目标 包括第一次实现前所未有的芳基卤化物的邻位氧化 通过一种新类别的亲电泳体实现；第二，开发五种直接邻近去功能化- 成员杂芳烃通过氧化和氧化还原中性方法；第三，使 一步羰基-1，2-转置反应。这项拟议的研究有望确定新的 合成方法和有效的催化剂系统，应提供通用和独特的 中常见的多取代芳烃和杂环的合成方法 药物或有效地将复杂分子中的羰基重新定位以生成 新颖的“官能团移位”类似物。

Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful palladium/norbornene (Pd/NBE) catalysis for site-specific arene/heteroarene vicinal di- functionalization and one-step carbonyl 1,2-transposition. Our objectives in the proposed funding period include first to realize a previously unprecedented ortho oxygenation of aryl halides enabled by a new class of electrophile; second to develop direct vicinal difunctionalization of five- membered heteroarenes via both oxidative and redox-neutral approaches; and third to enable a one-step carbonyl 1,2-transposition reaction. The proposed research is expected to identify new synthetic methods and efficient catalyst systems, which should provide general and distinct approaches to access poly-substituted arenes and heterocycles commonly found in pharmaceuticals or to efficiently relocate carbonyl groups in complex molecules for generating novel “functional group-shifted” analogues.