New Directions in Palladium/Norbornene Cooperative-Renewal
钯/降冰片烯合作更新的新方向
基本信息
- 批准号:10611466
- 负责人:
- 金额:$ 33.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-01 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAffectAlkenesAminationAromatic CompoundsBenzeneCarbonCatalysisChemistryComplexCoupledCouplingDataElementsFundingGoalsInvestigationKnowledgeLigandsLiteratureLocationMedicineMethodsNaphthaleneNitrogenOutcomeOxidation-ReductionOxygenPalladiumPharmaceutical PreparationsPharmacologic SubstancePositioning AttributePreparationProcessReactionResearchSiteSulfurSystemWorkanalogaryl halidebioactive natural productscarbonyl compoundcarbonyl groupcatalystdesigndrug discoveryfunctional groupimprovedmigrationnovelpublic health relevancesuccesstool
项目摘要
Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful
palladium/norbornene (Pd/NBE) catalysis for site-specific arene/heteroarene vicinal di-
functionalization and one-step carbonyl 1,2-transposition. Our objectives in the proposed funding
period include first to realize a previously unprecedented ortho oxygenation of aryl halides
enabled by a new class of electrophile; second to develop direct vicinal difunctionalization of five-
membered heteroarenes via both oxidative and redox-neutral approaches; and third to enable a
one-step carbonyl 1,2-transposition reaction. The proposed research is expected to identify new
synthetic methods and efficient catalyst systems, which should provide general and distinct
approaches to access poly-substituted arenes and heterocycles commonly found in
pharmaceuticals or to efficiently relocate carbonyl groups in complex molecules for generating
novel “functional group-shifted” analogues.
翻译后摘要:我们正在从事系统的努力,以开发新的,有效的,广泛有用的
Pd/NBE催化芳烃/杂芳烃邻位双
功能化和一步羰基1,2-转座。我们在拟议拨款中的目标
阶段包括首先实现先前前所未有芳基卤化物的邻位氧化
通过一类新的亲电体使能;第二,开发五种亲电体的直接邻位双官能化,
第三,通过氧化和氧化还原中性的方法,
一步羰基1,2-转座反应。这项研究预计将发现新的
合成方法和有效的催化剂体系,这应该提供一般的和不同的
获得多取代芳烃和杂环的方法通常存在于
或有效地重新定位复杂分子中的羰基以产生
新的“官能团转移”类似物。
项目成果
期刊论文数量(25)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Palladium-catalyzed asymmetric annulation between aryl iodides and racemic epoxides using a chiral norbornene cocatalyst.
- DOI:10.1039/c8qo00808f
- 发表时间:2018-06
- 期刊:
- 影响因子:0
- 作者:Renhe Li;Feipeng Liu;Guangbin Dong
- 通讯作者:Renhe Li;Feipeng Liu;Guangbin Dong
Modular ipso/ ortho Difunctionalization of Aryl Bromides via Palladium/Norbornene Cooperative Catalysis.
- DOI:10.1021/jacs.8b04153
- 发表时间:2018-07-11
- 期刊:
- 影响因子:15
- 作者:Dong Z;Lu G;Wang J;Liu P;Dong G
- 通讯作者:Dong G
Palladium/Norbornene Cooperative Catalysis.
- DOI:10.1021/acs.chemrev.9b00079
- 发表时间:2019-04
- 期刊:
- 影响因子:62.1
- 作者:Jianchun Wang;Guangbin Dong
- 通讯作者:Jianchun Wang;Guangbin Dong
Escape from Palladium: Nickel-Catalyzed Catellani Annulation.
- DOI:10.1021/jacs.3c03780
- 发表时间:2023-05
- 期刊:
- 影响因子:15
- 作者:Jingfeng Huo;Yue Fu;Melody J Tang;P. Liu;Guangbin Dong
- 通讯作者:Jingfeng Huo;Yue Fu;Melody J Tang;P. Liu;Guangbin Dong
Synthesis of C3,C4-Disubstituted Indoles via the Palladium/Norbornene-Catalyzed ortho-Amination/ipso-Heck Cyclization.
- DOI:10.1021/acs.orglett.1c01165
- 发表时间:2021-05-07
- 期刊:
- 影响因子:5.2
- 作者:Rago, Alexander J.;Dong, Guangbin
- 通讯作者:Dong, Guangbin
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Guangbin Dong其他文献
Guangbin Dong的其他文献
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{{ truncateString('Guangbin Dong', 18)}}的其他基金
Modular Synthesis of 1,2-Azaborines via Boron-mediated Strain-release Reductive Cyclization
通过硼介导的应变释放还原环化模块化合成 1,2-氮杂硼烷
- 批准号:
10329269 - 财政年份:2021
- 资助金额:
$ 33.76万 - 项目类别:
Modular Synthesis of 1,2-Azaborines via Boron-mediated Strain-release Reductive Cyclization
通过硼介导的应变释放还原环化模块化合成 1,2-氮杂硼烷
- 批准号:
10491122 - 财政年份:2021
- 资助金额:
$ 33.76万 - 项目类别:
New Directions in Palladium/Norbornene Cooperative - Instrument Supplement
钯/降冰片烯合作的新方向 - 仪器补充
- 批准号:
10382974 - 财政年份:2018
- 资助金额:
$ 33.76万 - 项目类别:
New Directions in Palladium/Norbornene Cooperative-Renewal
钯/降冰片烯合作更新的新方向
- 批准号:
10456439 - 财政年份:2018
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation of Ketones - Renewal 01
酮的催化 C-C 活化 - 更新 01
- 批准号:
10447204 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation: A "Cut and Sew" Approach to Bridged and Fused Rings
催化 C-C 激活:桥接环和熔合环的“裁剪和缝合”方法
- 批准号:
8744633 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation of Ketones - Renewal 01
酮的催化 C-C 活化 - 更新 01
- 批准号:
10447220 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation of Ketones - Renewal 01
酮的催化 C-C 活化 - 更新 01
- 批准号:
10194523 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation: A "Cut and Sew" Approach to Bridged and Fused Rings
催化 C-C 激活:桥接环和熔合环的“裁剪和缝合”方法
- 批准号:
8614748 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
Catalytic C-C Activation of Ketones - Renewal 01
酮的催化 C-C 活化 - 更新 01
- 批准号:
10647299 - 财政年份:2013
- 资助金额:
$ 33.76万 - 项目类别:
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