Catalytic C-C Activation: A "Cut and Sew" Approach to Bridged and Fused Rings

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DESCRIPTION (provided by applicant): We are engaged in the first systematic efforts to exploit catalytic ketone/unsaturated moiety coupling via C-C activation. Our objective, in the proposed funding period, is to develop a "Cut and Sew" strategy for the efficient synthesis of bridged/fused ring systems via catalytic C-C activation, which includes 1) regular "Cut and Sew": Rh- or Co-catalyzed intramolecular carboacylation with both strained and unstrained cyclic ketones; 2) decarbonylative "Cut and Sew": catalytic intramolecular couplings between cyclic ketones and unsaturated moieties with CO extrusion. The research proposed is expected to provide a general and unified strategy to build complex skeletons, found in numerous natural products and drugs, from simple starting materials.