New Directions in Palladium/Norbornene Cooperative - Instrument Supplement

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Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful palladium/norbornene (Pd/NBE) catalysis for site-specific arene mono- and di-functionalization. Our objective in the proposed funding period includes: first to develop new classes of vicinal di- functionalization, e.g. ortho amination, acylation, thiolation and annulation with epoxides by discovering new classes of electrophiles; and second to address the “ortho effect” limitation (requirement of a pre-existing ortho substituent) by developing new NBE-type ligands. The proposed research is expected to vastly expand the toolbox for arene functionalization via site- specifically installing functional groups at unactivated positions, which in turn would streamline synthesis of complex biologically important molecules containing multi-substituted aromatic scaffolds.