New Directions in Palladium/Norbornene Cooperative - Instrument Supplement

钯/降冰片烯合作的新方向 - 仪器补充

• 批准号: 10382974
• 负责人: Guangbin Dong
• 金额: $ 10.25万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10382974
• 关键词: Acylation; Address; Amination; Biological; Catalysis; Complex; Epoxy Compounds; Funding; Ligands; Palladium; Positioning Attribute; Research; Site; functional group; instrument; scaffold

Abstract: We are engaged in the systematic efforts to exploit new, efficient, and broadly useful palladium/norbornene (Pd/NBE) catalysis for site-specific arene mono- and di-functionalization. Our objective in the proposed funding period includes: first to develop new classes of vicinal di- functionalization, e.g. ortho amination, acylation, thiolation and annulation with epoxides by discovering new classes of electrophiles; and second to address the “ortho effect” limitation (requirement of a pre-existing ortho substituent) by developing new NBE-type ligands. The proposed research is expected to vastly expand the toolbox for arene functionalization via site- specifically installing functional groups at unactivated positions, which in turn would streamline synthesis of complex biologically important molecules containing multi-substituted aromatic scaffolds.

翻译后摘要：我们正在从事系统的努力，以开发新的，有效的，广泛有用的 钯/顺丁烯二烯（Pd/NBE）催化用于位点特异性芳烃单官能化和双官能化。 我们在建议资助期内的目标包括：首先发展新类别的邻位二进制数， 官能化，例如邻位胺化、酰化、硫醇化和与环氧化物的环化， 发现亲电试剂的新类别;第二，解决“邻位效应”限制 （需要预先存在的邻位取代基）。的 预计拟议的研究将大大扩展芳烃功能化的工具箱， 特别是在非活动职位上设立职能小组，这反过来又会精简 含多取代芳族化合物复杂生物重要分子的合成 脚手架