Catalytic C-C Activation of Ketones - Renewal 01

酮的催化 C-C 活化 - 更新 01

• 批准号: 10647299
• 负责人: Guangbin Dong
• 金额: $ 8.83万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10647299
• 关键词: Carbon; Catalysis; Chemicals; Chemistry; Cobalt; Complex; Funding; Goals; Hydrogen Bonding; Indole Alkaloids; Ketones; Laboratories; Mediating; Methods; Natural Product Drug; Oxidation-Reduction; Process; Research; Skeleton; Structure; Surface; System; Transition Elements; Work; analog; bioactive natural products; carbon skeleton; catalyst; cofactor; functional group; interest; novel; public health relevance; small molecule; success

Abstract: We are engaged in the systematic efforts to exploit catalytic carbon–carbon (C−C) bond activation for developing new, general and synthetically useful methods. Our objective, in the proposed funding period, is to focus on C−C activation of ketones, as ketone moieties are ubiquitously found in feedstock chemicals, synthetic building blocks and bioactive compounds. Specifically, we will: (i) expand the scope and utilities with activation of strained ketones for constructing complex ring systems, (ii) enable new and broadly applicable transformations with unstrained ketones in an atom-economical fashion, and (iii) explore a new activation mode that can shift the paradigm for ketone activation. The research proposed is expected to simplify synthesis through new strategic bond disconnections, allow for editing skeletons of complex molecules under redox-neutral conditions, and offer a byproduct-free approach to access organic building blocks.

摘要：我们致力于系统地开发催化碳-碳（C−C） 键激活用于开发新的、通用的和综合有用的方法。我们的目标，在 拟议的资助期将重点关注酮的 C−C 激活，因为酮部分是 普遍存在于原料化学品、合成结构单元和生物活性化合物中。 具体来说，我们将：（i）通过激活应变酮来扩大范围和效用 构建复杂的环系统，(ii) 实现新的且广泛适用的转换 以原子经济的方式制备无张力的酮，以及（iii）探索一种新的活化模式 可以改变酮激活的范式。拟议的研究预计将简化 通过新的战略键断开进行合成，允许编辑复杂的骨架 分子在氧化还原中性条件下，并提供无副产物的方法来获取 有机构建块。