RC-BMAC

BMAC摘要/摘要： 基础科学的影响越来越大地影响着医疗实践。这一趋势可能只会在#年加速。 在不久的将来，包括基因治疗和基于CRISPR的基因编辑在内的技术开始影响临床 关心。这一方法的持续进展及其在老年医学中的应用需要无缝集成 基础研究人员、翻译研究人员和临床研究人员。为了促进这种整合，我们提议创建 此应用程序的新核心。这个名为《运动和衰老生物学核心》(BMAC)的核心将促进 临床医生和基础科学家的工作，通过将老年科学的原则联系起来，推动新的治疗方法 提高平衡性和机动性。这些包括识别新的生物标记物，阐明新的分子 药物治疗的靶点，使用深入的动物表型来评估新的生物制剂，通常 促进人文科学与基础科学之间的双向翻译。这项工作最终将有助于催化 我们的胡椒中心能够进行首个人类临床试验的新药，以保持灵活性和 晚年生活中的平衡。令人兴奋的是，其中一些努力已经启动。通过支持飞行员， 除了开发和外部项目，BMAC还提高了我们的OAIC的严谨性、实力和质量。 此外，BMAC资源包括最先进的仪器和方法、一系列 研讨会和教学，以及实验室访问、独特的基因试剂和深入咨询，将 变得广泛和容易接触到胡椒调查人员。BMAC包括国际知名的 组成一组高级调查人员的教职员工，他们的知识涵盖神经科学、肌肉 生理学、临床前动物表型、代谢组学、翻译药理学、微生物组和 高通量遗传和化学筛选平台。所有BMAC教职员工都使用最先进的和良好的- 资助与流动性和衰老生物学相关领域的实验室。

BMAC Summary/Abstract: The impact of basic science is increasingly influencing medical practice. This trend will likely only accelerate in the near future, as techniques including gene therapy and CRISPR-based gene editing begin to impact clinical care. The continued progress of this approach, and its application to geriatrics, requires a seamless integration of basic, translational and clinical researchers. In order to facilitate this integration, we are proposing creation of a new Core for this application. Entitled, the Biology of Mobility and Aging Core (BMAC), this Core will foster the work of clinicians and basic scientists by linking the tenets of `geroscience' to advance new treatments to improve balance and mobility. These include the identification of new biomarkers, elucidating new molecular targets for drug therapy, using in-depth animal phenotyping to assess new biologic agents, and generally promoting back and forth translation between human and basic studies. This work will ultimately help catalyze the ability of our Pepper Center to conduct first-in-human clinical trials of novel agents to preserve mobility and balance in late life. Excitingly, some of these efforts have already been initiated. By supporting pilot, developmental, and external projects, the BMAC also enhances the rigor, strength and quality of our OAIC. Moreover, BMAC resources that include state-of-the-art instrumentation and methodologies, a range of seminars and didactics, as well as laboratory visits, unique genetic reagents and in-depth consultations, will become widely and easily accessible to Pepper investigators. The BMAC includes internationally renowned faculty members who constitute a group of senior investigators with knowledge spanning neuroscience, muscle physiology, pre-clinical animal phenotyping, metabolomics, translational pharmacology, the microbiome and high throughput genetic and chemical screening platforms. All BMAC faculty operate state-of-the-art and well- funded laboratories in areas relevant to the biology of mobility and aging.