RC-BMAC

RC-BMAC

• 批准号: 10221537
• 负责人: TOREN FINKEL
• 金额: $ 13.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10221537
• 关键词: Adoption; Aging; American; Animal Model; Animals; Area; Back; Basic Science; Biological; Biological Markers; Biological Models; Biological Process; Biological Products; Biological Sciences; Biology; Biology of Aging; CRISPR screen; Capsicum; Chemicals; Clinical; Clinical Trials; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Complement; Consultations; Core Facility; Development; Doctor of Philosophy; Drosophila genus; Elderly; Equilibrium; Faculty; Fostering; Foundations; Funding; Future; Gait; Genes; Genetic; Geriatrics; Geroscience; Goals; Human; Impairment; Individual; Inflammation; Institutes; International; Intervention; Investments; Knowledge; Laboratories; Language; Leadership; Link; Medical; Methodology; Mission; Molecular; Molecular Target; Muscle function; Muscle satellite cell; Neurosciences; Organism; Pharmacology; Phenotype; Pilot Projects; Pre-Clinical Model; Process; Reagent; Research Personnel; Research Support; Research Training; Resources; Rodent; Science; Scientist; System; Techniques; Technology; Translating; Translations; Visit; Work; Zebrafish; age related; base; biomarker development; clinical care; clinical practice; design; exosome; first-in-human; gene therapy; healthspan; high throughput analysis; high throughput screening; improved; innovation; insight; instrumentation; member; metabolomics; microbiome; molecular drug target; molecular targeted therapies; muscle physiology; novel; novel marker; novel therapeutics; pre-clinical; preservation; prevent; recruit; screening; single-cell RNA sequencing; small molecule libraries; square foot; targeted treatment; tool; translational study; trend; whole genome

BMAC Summary/Abstract: The impact of basic science is increasingly influencing medical practice. This trend will likely only accelerate in the near future, as techniques including gene therapy and CRISPR-based gene editing begin to impact clinical care. The continued progress of this approach, and its application to geriatrics, requires a seamless integration of basic, translational and clinical researchers. In order to facilitate this integration, we are proposing creation of a new Core for this application. Entitled, the Biology of Mobility and Aging Core (BMAC), this Core will foster the work of clinicians and basic scientists by linking the tenets of `geroscience' to advance new treatments to improve balance and mobility. These include the identification of new biomarkers, elucidating new molecular targets for drug therapy, using in-depth animal phenotyping to assess new biologic agents, and generally promoting back and forth translation between human and basic studies. This work will ultimately help catalyze the ability of our Pepper Center to conduct first-in-human clinical trials of novel agents to preserve mobility and balance in late life. Excitingly, some of these efforts have already been initiated. By supporting pilot, developmental, and external projects, the BMAC also enhances the rigor, strength and quality of our OAIC. Moreover, BMAC resources that include state-of-the-art instrumentation and methodologies, a range of seminars and didactics, as well as laboratory visits, unique genetic reagents and in-depth consultations, will become widely and easily accessible to Pepper investigators. The BMAC includes internationally renowned faculty members who constitute a group of senior investigators with knowledge spanning neuroscience, muscle physiology, pre-clinical animal phenotyping, metabolomics, translational pharmacology, the microbiome and high throughput genetic and chemical screening platforms. All BMAC faculty operate state-of-the-art and well- funded laboratories in areas relevant to the biology of mobility and aging.

BMAC总结/摘要： 基础科学对医疗实践的影响越来越大。这一趋势可能只会加速， 在不久的将来，包括基因治疗和基于CRISPR的基因编辑在内的技术开始影响临床 在乎这种方法的持续进展及其在老年医学中的应用需要无缝集成 基础、转化和临床研究人员。为了促进这种融合，我们建议建立 为这个应用程序提供一个新的核心。移动性和衰老核心生物学（BMAC），这个核心将促进 临床医生和基础科学家的工作，将"老年科学"的原则与推进新的治疗方法联系起来， 改善平衡和流动性。这些包括鉴定新的生物标志物，阐明新的分子生物学， 药物治疗的靶点，使用深入的动物表型来评估新的生物制剂， 促进人类和基础研究之间的来回翻译。这项工作最终将有助于催化 我们的胡椒中心进行新药物的首次人体临床试验的能力，以保持流动性， 晚年的平衡令人兴奋的是，其中一些努力已经开始。通过支持试点， BMAC还加强了OAIC的严谨性、实力和质量。 此外，BMAC资源包括最先进的仪器和方法，一系列 研讨会和教学法，以及实验室访问、独特的遗传试剂和深入的咨询，将 胡椒调查人员可以广泛和容易地接触到。BMAC包括国际知名的 教师谁构成了一组资深研究人员与知识跨越神经科学，肌肉 生理学、临床前动物表型、代谢组学、转化药理学、微生物组和 高通量遗传和化学筛选平台。所有BMAC教师操作国家的最先进的和良好的- 在与移动性和衰老生物学相关的领域资助实验室。