TRAINING IN ORTHOPEDIC SKELETAL BIOLOGY

描述(申请人提供)：这是一份综合博士后和博士后培训支持的申请，将把尖端的临床策略与关于骨骼组织修复和再生的机制和生物学的实验研究结合起来。该提案基于以拉什大学医学中心解剖和细胞生物学系为中心的骨骼生物学项目，与整形外科系(包括该国最重要的临床整形外科小组之一以及一批杰出的基础科学家)合作。来自Rush的另外两个临床部门(内科风湿科和整形与重建外科)的教员预计将作为导师或联合导师参加。拟议计划的目标是为对骨骼生物学多学科领域的学术生涯感兴趣的博士生、博士后研究员和医学生提供教育、培训和研究机会。该计划将强调骨骼修复和再生的机制，以指导对整形外科、风湿病和颅面外科的基础生物学研究基础的培训。我们请求为3名研究生、2名博士后研究员和2名短期研究实习生提供支持。除了传统的博士生和MD/博士生外，还将特别努力招收寻求MD/MS混合学位的学生。虽然我们的MD/MS项目相对较新，但所有参加过的学生都走上了一条非常鼓舞人心的成为内科科学家的道路。我们认为这条赛道对于对外科职业感兴趣的学生来说特别重要，因为临床培训要求非常长。因此，强调MD/MS(相对于MD/PhD)仍然允许有意义的紧张研究经历，但整个培训方案只增加了一年(而不是三年)。在博士后方面，我们计划特别关注医学博士和医学博士/博士的招聘。短期研究实习生机制将被用作为仍在考虑MD/MS或MD/PHD方案的医学生提供研究入门的一种方式。我们正在采取这一战略，以帮助增加骨科骨骼生物学领域的内科科学家数量。相关性：这笔赠款将帮助培训科学家改善受损骨骼和关节的愈合。目前的整形外科手术是成功的，但我们希望通过更好地了解身体用于自我修复的潜在病理和机制来改善结果。最终，治疗将更多地依赖于身体的自然自我更新能力，而不是更少地使用人造材料。

DESCRIPTION (provided by applicant): This is an application for integrated pre- and post-doctoral training support that will bring together cutting edge clinical strategies with experimental investigations on the mechanisms and biology of skeletal tissue repair and regeneration. The proposal is based in the skeletal biology program centered in the Department of Anatomy & Cell Biology at Rush University Medical Center in partnership with the Department of Orthopedic Surgery (which includes one of the premier clinical orthopedic groups in the country as well as an outstanding group of basic scientists). Faculty from two other clinical departments at Rush (Section of Rheumatology from the Department of Internal Medicine and the Department of Plastics & Reconstructive Surgery) are expected to participate as mentors or co-mentors. The objective of the proposed program is to provide education, training and research opportunities to doctoral students, postdoctoral fellows and medical students interested in academic careers in the multi-disciplinary area of skeletal biology. The program will emphasize mechanisms of skeletal repair and regeneration in order to direct training to basic biological research foundations for orthopedics, rheumatology and craniofacial surgery. We are requesting support for 3 graduate students, 2 post-doctoral fellows and 2 short-term research trainees. In addition to traditional PhD students and MD/PhD students, a special effort will be made to recruit students seeking combined MD/MS degrees. Although our MD/MS program is relatively new, all of the students who have participated are on a very encouraging track of becoming physician-scientists. We think this track is particularly important for students interested in surgical careers because of the extremely long clinical training requirements. Thus, emphasis on the MD/MS (as opposed to the MD/PhD) still permits a meaningful intense research experience, but adds only one year (as opposed to three years) to the entire training regimen. At the post-doctoral level, we plan to pay special attention to the recruitment of MDs and MD/PhDs. The short-term research trainee mechanism will be used as a way to provide an introduction to research for medical students who are still considering the MD/MS or MD/PhD option. We are taking this strategy to help bolster the number of physician-scientists in orthopedic skeletal biology. Relevance: This grant will help train scientists to improve healing of damaged bone and joints. Current orthopedic procedures are successful, but we hope to improve outcomes through a better understanding of the underlying pathologies and mechanisms the body uses to repair itself. Eventually, treatments will rely more on the body's natural ability at self-renewal and less on the use of artificial materials.