"Recruitment of a Bone and Cancer Early Stage Investigator"

描述(由申请人提供)：该项目的目标是通过促进招聘一名新的早期研究员到终身教职跟踪教职职位，继续在拉什大学医学中心发展骨与癌症核心中心。医学中心有一大批基础和翻译研究人员，专注于结缔组织，特别是骨、关节软骨和肌腱和韧带。医疗中心的两个重要战略重点领域包括整形外科和癌症，一些建筑项目、新招聘人员和即将完成的癌症主任招聘就证明了这一点。作为两个部门之间的合作项目 在解剖与细胞生物学和整形外科系的合作下，我们最近招聘了一名由NIH资助的具有癌症生物学专业知识的资深教员加入我们新设立的骨骼和癌症课程。通过这一拨款机制，我们现在建议通过招募一名以实验室为基础的早期研究员来扩大骨与癌症计划，该研究员致力于与临床医生一起设计和实施转化性癌症研究。我们已经完成了初步寻找阶段，并面试了三名优秀的候选人。在这些候选人中，我们根据候选人的研究领域和表达了拥有强大的翻译成分与我们的临床和基础科学研究优势之间的“契合度”来优先排序。骨与癌症的主要使命是通过改善对癌症生存和转移机制的了解来促进患者的治疗。关于癌症干细胞在抵抗治疗中的潜在重要性以及骨转移中的骨微环境，现在已经有了很大的了解。骨骼和癌症核心中心的发展是支持Rush癌症研究活动的理想方式，因为可以利用骨骼研究和临床整形肿瘤学的巨大优势为拟议的活动提供行政和科学支持。

DESCRIPTION (Provided by the applicant): The goal of this project is to continue the development of a Core Center in Bone and Cancer at Rush University Medical Center by facilitating the recruitment of a new early stage investigator to a tenure-track faculty position. The Medical Center has a large group of basic and translational researchers focusing on connective tissues, particularly bone, articular cartilage and tendons and ligaments. Two important strategic focus areas for the Medical Center include orthopedics and cancer, as evidenced by a number of building projects, new recruits and the nearly completed recruitment of a cancer director. As a cooperative venture between the Department of Anatomy & Cell Biology and the Department of Orthopedic Surgery, we have recently recruited a senior, NIH funded, faculty member with expertise in cancer biology into our newly established bone and cancer program. Through this grant mechanism, we now propose to expand the bone and cancer program by recruiting a laboratory-based early stage investigator who is committed to a career working with clinicians in the design and implementation of translational cancer research. We have already completed the initial search phase and have interviewed three outstanding candidates. Among these candidates, we have prioritized our ranking based on the "fit" between the candidate's research area and expressed desire to have a strong translational component and our clinical and basic science research strengths. The major mission of the Bone and Cancer is to advance patient treatment through improved understanding of cancer survival and metastasis mechanisms. A great deal is now being learned about the potential importance of cancer stem cells in resistance to treatment and the bone microenvironment in bone metastases. The development of a Bone and Cancer Core Center represents an ideal way to bolster cancer research activity at Rush since the great strengths in skeletal research and clinical orthopedic oncology can be leveraged to provide administrative and scientific support for the proposed activities.