Microbiology and Virology Core

核心C微生物学和病毒学。在过去的31年里，微生物学和病毒学核心 通过创建和维护广泛的传染病（ID）来支持该计划的项目 数据库该数据库对于具有传染病终点的项目至关重要。来 多年来，核心小组的职能和提供的服务有所扩大，主要是由于 高灵敏度和定量诊断能力，这使得必须有标准化的 程序诊断测试结果的定义和解释。因此，所有感染终点 对于与项目目标相关的临床试验或研究，与核心主任讨论， 为与项目相关的特定ID分析提供统计支持和数据管理。国家 提供了最先进的诊断能力，并不断努力改进诊断能力， 造血细胞移植受者相关病原体的能力。核心还保持着一个 前瞻性样本收集，以便于使用研究诊断测定进行感染诊断。此外，本发明还提供了一种方法， 核心为免疫重建研究提供了监测能力。具体而言，核心提供 以下服务： 1.检测隐匿性感染和病原体的最新诊断分子能力 定量这些测定将应用于特发性肺炎综合征患者， 优化BAL和组织定量分子诊断。 2.为项目和核心领导人提供数据管理和统计服务。 3. ID数据库的数据输入和质量控制。 4.协助项目和核心领导人定义ID端点，包括确保适当使用 身份证数据库，并协助分析身份证数据。 5.维护组织样本库（BAL和血液）。 6.用于T细胞测定的抗原制备。

Core C Microbiology and Virology. For the past 31 years, the Microbiology and Virology Core has supported the projects of this Program by creating and maintaining an extensive Infectious Diseases (ID) database. This database has been critical for projects that have Infectious Disease endpoints. Over the years the function and services provided by the Core have expanded, mainly driven by the availability of highly sensitive and quantitative diagnostic capabilities, which made it imperative to have standardized definitions and interpretations of diagnostic test results for the Programs. Therefore, all infection endpoints for clinical trials or studies related to the aims of the projects are discussed with the Core director, the Core provides statistical support and data management for specific ID analyses related to the projects. State-of - the-art diagnostic capabilities are provided and continuous efforts are made to improve diagnostic capabilities for pathogens relevant to hematopoietic cell transplant recipients. The Core also maintains a prospective sample collection to facilitate infection diagnosis using research diagnostic assays. In addition, the Core provides monitoring capabilities for immune reconstitution studies. Specifically, the Core provides the following services: 1. State-of-the-art diagnostic molecular capabilities for the detection of occult infections and pathogen quantitation. These assays will be applied in patients with idiopathic pneumonia syndrome and for optimizing BAL and tissue-based quantitative molecular diagnosis. 2. Provision of data management and statistical services to Project and Core leaders. 3. Data entry and quality control of the IDdatabases. 4. Assistance to Project and Core leaders in defining ID endpoints, including assurance of appropriate use of ID database, and assistance in analysis of ID data. 5. Maintaining a tissue sample repository (BAL and blood). 6. Antigen preparation for T cell assays.