Training Program in Infectious Diseases in the Immunocompromised Host

免疫功能低下宿主传染病培训计划

• 批准号: 10593365
• 负责人: MICHAEL J BOECKH
• 金额: $ 32.36万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593365
• 关键词: Training; Program; Infectious; Diseases; Immunocompromised

PROJECT SUMMARY Our interdisciplinary training program, based at the Fred Hutchinson Cancer Research Center (Fred Hutch), focuses on Infectious Diseases in the Immunocompromised Host. Our objective is to recruit and train outstanding physician-scientists and postdoctoral PhD scientists to perform basic, translational and clinical research, using state-of-the-art methods and analytical techniques. Our overarching goal is to train the next generation of leaders in the field, who will use their expertise to advance our understanding of infectious disease biology and pathogenesis, and to develop novel strategies to prevent, treat and control infectious diseases in high-risk immunocompromised patients. There is increasing demand for research training in this field: infection remains a major cause of morbidity and mortality for immunocompromised hosts, and millions are at risk or affected by established pathogens and emerging pathogens such as SARS-CoV-2. The population of immunocompromised individuals in the United States continues to grow, driven by advances in transplantation techniques and cancer treatments, increased survival of these patients, and the development of novel drugs and biological agents to treat autoimmune diseases. As part of an NCI-designated cancer consortium whose renowned faculty have contributed landmark advances in the field of infectious diseases of the immunocompromised host for the past 40 years, and whose expertise collectively encompass all facets of this field, Fred Hutch is uniquely positioned to successfully lead this training program. In partnership with the University of Washington (UW), the Infectious Disease Sciences Program of Fred Hutch has an excellent, multi-decade track record of training physician-scientists and postdoctoral PhD scientists who launch independent research careers in academia, government research, or industry leadership positions. Our funded T32 grant has allowed us to expand our training program and solidify funding for trainees in this specialized area of infectious diseases. We seek to maintain this high standard of training; the T32 will support 2 new, qualified trainees (MDs and/or PhDs) per year, for 3 years of training each. T32 trainees pursue one of three consolidated research tracks that represent the unique strengths of our immunocompromised host program and its mentors: 1) Clinical Research, Infection Prevention, and Stewardship; 2) Immunology/Immunogenetics; and 3) Microbiome and Pathogenesis. These tracks provide training in unique aspects of this field and will assure that trainees develop expertise in epidemiology, diagnosis, management and host-pathogen interactions. All trainees participate in a rigorous core curriculum consisting of courses, lectures, retreats, research and targeted career development activities; trainees also have the opportunity to complete a master’s degree at UW. Our training program helps to address the national need for researchers that focus their clinical and/or laboratory investigation on Infectious Diseases in the Immunocompromised Host, and provides those trainees with the skills and expertise to successfully transition into independent research careers.

项目摘要 我们的跨学科培训计划，基于弗雷德哈钦森癌症研究中心（弗雷德哈奇）， 重点是免疫受损宿主的传染病。我们的目标是招募和训练 优秀的医生科学家和博士后博士科学家进行基础，翻译和临床 使用最先进的方法和分析技术进行研究。我们的首要目标是培养下一个 在该领域的一代领导人，谁将利用他们的专业知识，以促进我们对传染病的理解， 疾病生物学和发病机制，并制定新的战略，以预防，治疗和控制传染病， 高危免疫功能低下患者的疾病。在这方面，对研究培训的需求越来越大。 感染仍然是免疫功能低下宿主发病和死亡的主要原因， 有风险或受到已确定的病原体和新出现的病原体（如SARS-CoV-2）的影响。的 美国免疫功能低下人群继续增长，这是由以下方面的进展推动的： 移植技术和癌症治疗，增加这些患者的生存率，以及 治疗自身免疫性疾病的新药物和生物制剂。作为国家癌症研究所指定癌症的一部分 该联盟的著名教师在传染病领域取得了里程碑式的进展， 免疫功能低下的主机在过去的40年，其专业知识共同涵盖的所有方面， 在这一领域，弗雷德哈奇是唯一的定位，成功地领导这一培训计划。伙伴合作下 华盛顿大学（UW）的弗雷德·哈奇传染病科学项目有一个优秀的， 几十年来，培养医生科学家和博士后博士科学家的记录， 在学术界，政府研究或行业领导职位的独立研究生涯。我们的资助 T32赠款使我们能够扩大我们的培训计划，并巩固资金，为学员在这一专业 传染病领域。我们寻求保持这种高标准的培训; T32将支持2个新的， 合格的受训人员（医学博士和/或博士）每年，为期3年的培训。T32学员追求三个之一 代表我们免疫受损宿主项目独特优势的综合研究跟踪 及其导师：1）临床研究，感染预防和管理; 2）免疫学/免疫遗传学; 和3）微生物组和发病机制。这些课程提供该领域独特方面的培训，并将 确保受训人员掌握流行病学、诊断、管理和宿主病原体方面的专门知识 交互.所有学员都参加严格的核心课程，包括课程、讲座、务虚会， 研究和有针对性的职业发展活动;学员也有机会完成硕士学位 在UW度我们的培训计划有助于满足国家对专注于临床研究的研究人员的需求。 和/或实验室调查传染病在免疫功能低下的主机，并提供这些 学员的技能和专业知识，成功地过渡到独立的研究事业。