Synaptic Circuit Organization of Motor Cortex

运动皮层的突触电路组织

基本信息

  • 批准号:
    10451517
  • 负责人:
  • 金额:
    $ 43.16万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-08-01 至 2023-11-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Sensory-guided movements of the arms and hands are essential for many activities of daily living. Pathological processes that impair the cortical circuits mediating these behaviors are a common cause of disability. To better understand and treat these disorders, it will be important to understand the cellular mechanisms in these circuits. Our progress in the previous grant period has helped to elucidate many aspects of the circuit organization of primary motor cortex (M1) neurons in the forelimb area of mouse neocortex. However, a fundamental question remains poorly understood: how are forelimb M1 neurons integrated into functional synaptic circuits with the cells and circuits of primary somatosensory cortex (S1)? This is important to determine, because while the critical importance of somatosensation in controlling movements is well established, the circuits mediating sensorimotor integration in this system are not well characterized. Our working hypothesis is that the forelimb S1—M1 circuit is configured by the cell-type-specific connections of its cortical and thalamic projection neurons to support feedforward somatosensory→motor signaling along complex yet highly specific polysynaptic pathways, leading to excitation of corticospinal neurons. Defining the cellular components of this transcortical loop would be a major step toward elucidating how tactile information is communicated to and integrated by motor cortex neurons to influence cortical output to the spinal cord, in the service of fluid volitional forelimb movements. We propose a research program to test a series of predictions about the cellular organization of the forelimb S1—M1 circuit. The overall aim is to determine the cellular basis for key long-range excitatory circuit connections that mediate communication between forelimb S1 and M1, and between these areas and somatosensory and motor nuclei in the thalamus, particularly the ventral posterior, posterior, and ventrolateral nuclei. To this end, in vivo labeling and ex vivo optogenetic- electrophysiological methods will be used to systematically delineate the cell-type-specific connections mediating thalamus→cortex (Aim 1), cortex→thalamus (Aim 2), and cortex→cortex (Aim 3) communication in this sensorimotor circuit. Overall, the proposed research program is significant and innovative, we believe, because it will generate basic new information about the cellular/synaptic mechanisms underlying the somatosensory→motor transformations at the level of cell-type-specific circuits of the neocortex and thalamus, and thus about the mechanistic basis for sensorimotor functions of the forelimb.
项目总结

项目成果

期刊论文数量(31)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ephus: multipurpose data acquisition software for neuroscience experiments.
  • DOI:
    10.3389/fncir.2010.00100
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Suter BA;O'Connor T;Iyer V;Petreanu LT;Hooks BM;Kiritani T;Svoboda K;Shepherd GM
  • 通讯作者:
    Shepherd GM
Manipulation-specific cortical activity as mice handle food.
  • DOI:
    10.1016/j.cub.2022.09.045
  • 发表时间:
    2022-11-21
  • 期刊:
  • 影响因子:
    9.2
  • 作者:
    Barrett, John M;Martin, Megan E;Shepherd, Gordon M G
  • 通讯作者:
    Shepherd, Gordon M G
Corrigendum: Scaling of Optogenetically Evoked Signaling in a Higher-Order Corticocortical Pathway in the Anesthetized Mouse.
勘误表:麻醉小鼠高阶皮质通路中光遗传学诱发信号的缩放。
  • DOI:
    10.3389/fnsys.2018.00050
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Li,Xiaojian;Yamawaki,Naoki;Barrett,JohnM;Körding,KonradP;Shepherd,GordonMG
  • 通讯作者:
    Shepherd,GordonMG
Circuit mapping by ultraviolet uncaging of glutamate.
  • DOI:
    10.1101/pdb.prot070664
  • 发表时间:
    2012-09-01
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shepherd, Gordon M G
  • 通讯作者:
    Shepherd, Gordon M G
Diversity and complexity in the pyramidal tract projectome.
锥体束投影组的多样性和复杂性。
  • DOI:
    10.1038/nrn3469-c2
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shepherd,GordonMG
  • 通讯作者:
    Shepherd,GordonMG
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Gordon M Shepherd其他文献

Gordon M Shepherd的其他文献

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{{ truncateString('Gordon M Shepherd', 18)}}的其他基金

Towards a neurobiology of "oromanual" motor control: behavioral analysis and neural mechanisms
走向“手动”运动控制的神经生物学:行为分析和神经机制
  • 批准号:
    10819032
  • 财政年份:
    2023
  • 资助金额:
    $ 43.16万
  • 项目类别:
Bidirectional circuits of locus ceruleus and motor cortex neurons
蓝斑和运动皮层神经元的双向回路
  • 批准号:
    10447235
  • 财政年份:
    2022
  • 资助金额:
    $ 43.16万
  • 项目类别:
Developing new paradigms for mouse forelimb sensorimotor circuit analysis
开发小鼠前肢感觉运动电路分析的新范例
  • 批准号:
    10371764
  • 财政年份:
    2021
  • 资助金额:
    $ 43.16万
  • 项目类别:
Towards elucidation of circuit mechanisms for feeding-related manual dexterity
阐明与喂养相关的手动灵巧性的电路机制
  • 批准号:
    9982480
  • 财政年份:
    2020
  • 资助金额:
    $ 43.16万
  • 项目类别:
Brainstem circuits of corticospinal neurons
皮质脊髓神经元的脑干回路
  • 批准号:
    9977340
  • 财政年份:
    2020
  • 资助金额:
    $ 43.16万
  • 项目类别:
In Vivo Analysis of Cortical Projection Neurons
皮质投射神经元的体内分析
  • 批准号:
    8816156
  • 财政年份:
    2014
  • 资助金额:
    $ 43.16万
  • 项目类别:
Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste
听觉系统中皮质小丘调节的细胞机制
  • 批准号:
    8803418
  • 财政年份:
    2014
  • 资助金额:
    $ 43.16万
  • 项目类别:
Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste
听觉系统中皮质小丘调节的细胞机制
  • 批准号:
    8827754
  • 财政年份:
    2014
  • 资助金额:
    $ 43.16万
  • 项目类别:
Synaptic Circuit Organization of Motor Cortex
运动皮层的突触电路组织
  • 批准号:
    8632022
  • 财政年份:
    2008
  • 资助金额:
    $ 43.16万
  • 项目类别:
Synaptic Circuit Organization of Motor Cortex
运动皮层的突触电路组织
  • 批准号:
    8303317
  • 财政年份:
    2008
  • 资助金额:
    $ 43.16万
  • 项目类别:

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