Brainstem circuits of corticospinal neurons
皮质脊髓神经元的脑干回路
基本信息
- 批准号:9977340
- 负责人:
- 金额:$ 69.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2023-06-30
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnimalsAxonBar CodesBehavioralBrain StemCell NucleusCellsCerebrovascular DisordersCommunicationComplementDemyelinating DiseasesDiseaseElectrophysiology (science)FoundationsFutureGoalsHealthImageIndividualInferiorLabelLeadLengthMammalsMapsMediatingMethodsMidbrain structureMissionModelingMolecularMonitorMotorMotor CortexMultiplexed Analysis of Projections by SequencingMusMuscleNeuronsOlives - dietaryPathologyPathway interactionsPontine structureProcessPropertyPublic HealthPyramidal TractsResearchResolutionRoleSamplingSensorySignal TransductionSliceSourceSpinalSpinal CordSpinal cord injuryStructure of nucleus cuneatusSurveysSynapsesSystemTechniquesTextbooksUnited States National Institutes of HealthViralbasecell typeconnectomedisabilityimprovedin vivointerestlocus ceruleus structuremotor behaviormotor controlmotor impairmentnerve supplynervous system disorderneuroregulationnoradrenergicoptogeneticspostsynapticpostsynaptic neuronsprogramsreconstructionsomatosensorysubcellular targetingsystems researchtool
项目摘要
PROJECT SUMMARY
Corticospinal axonal projections are critical for mammalian motor control. Their length and complexity makes
them vulnerable to an exceptionally wide range of neurological disease processes including cerebrovascular
disorders, demyelinating diseases, ALS, spinal cord injury, and more. Corticospinal research has naturally
focused on cortical and spinal mechanisms. However, corticospinal axons, like those of other types of pyramidal
tract neurons, can send branches to the midbrain, pons, and medulla along the way to the spinal cord. The
anatomical “projectome” of corticospinal axonal branching to brainstem targets has not been systematically
investigated. Even less is known about the synaptic “connectome”; i.e., the cellular circuits formed by
corticospinal input to postsynaptic neurons in various brainstem nuclei. Elucidating the brainstem circuits of
corticospinal axons will be important for understanding the cellular basis of mammalian motor control. For
example, there very likely are as-yet unrecognized subtypes of corticospinal neurons that, through differential
innervation of brainstem targets, mediate specific sensorimotor, neuromodulatory, or other functions essential
for motor coordination and control. We propose a two-pronged approach to investigate the brainstem branches
and circuits of corticospinal axons in the mouse. In Aim 1, we will use a high-throughput molecular barcoding
technique, MAPseq, to characterize the diversity and complexity of corticospinal projections to the brainstem,
with single-axon resolution and large-scale sampling. In Aim 2, we will use optogenetic, electrophysiological,
imaging, and viral labeling tools to characterize the cell-type-specific synaptic connectivity in these circuits. The
projections and connections of corticospinal axons’ brainstem branches will be both broadly surveyed across
regions (midbrain, pons, medulla) and analyzed in a more focused manner at the level of specific types of
projection neurons in key nuclei, including those associated with sensorimotor, neuromodulatory, and other
systems (reticular, pontine, cuneate, locus coeruleus, and more). Results from this discovery-oriented research
program will lay the groundwork for future hypothesis-oriented studies to investigate – at the mechanistically
important level of specific cell types and their synaptic connectivity – how the brainstem circuits of corticospinal
neurons contribute to mammalian motor function.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gordon M Shepherd其他文献
Gordon M Shepherd的其他文献
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{{ truncateString('Gordon M Shepherd', 18)}}的其他基金
Towards a neurobiology of "oromanual" motor control: behavioral analysis and neural mechanisms
走向“手动”运动控制的神经生物学:行为分析和神经机制
- 批准号:
10819032 - 财政年份:2023
- 资助金额:
$ 69.32万 - 项目类别:
Bidirectional circuits of locus ceruleus and motor cortex neurons
蓝斑和运动皮层神经元的双向回路
- 批准号:
10447235 - 财政年份:2022
- 资助金额:
$ 69.32万 - 项目类别:
Developing new paradigms for mouse forelimb sensorimotor circuit analysis
开发小鼠前肢感觉运动电路分析的新范例
- 批准号:
10371764 - 财政年份:2021
- 资助金额:
$ 69.32万 - 项目类别:
Towards elucidation of circuit mechanisms for feeding-related manual dexterity
阐明与喂养相关的手动灵巧性的电路机制
- 批准号:
9982480 - 财政年份:2020
- 资助金额:
$ 69.32万 - 项目类别:
Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste
听觉系统中皮质小丘调节的细胞机制
- 批准号:
8803418 - 财政年份:2014
- 资助金额:
$ 69.32万 - 项目类别:
Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste
听觉系统中皮质小丘调节的细胞机制
- 批准号:
8827754 - 财政年份:2014
- 资助金额:
$ 69.32万 - 项目类别:
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