Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste

听觉系统中皮质小丘调节的细胞机制

基本信息

项目摘要

DESCRIPTION (provided by applicant): Corticofugal - top-down - pathways from primary auditory cortex (A1) to the auditory brainstem powerfully modulate auditory processing. One important top-down pathway is mediated by corticocollicular neurons: a subset of layer (L) 5 pyramidal neurons in A1 with long-range axonal projections to the inferior colliculus (IC). The corticocollicular projection shapes the response properties of IC neurons, and mediates sound localization learning. However, previous physiological studies of A1 corticofugal mechanisms have not specifically targeted corticocollicular neurons. Therefore, basic physiological properties of corticocollicular neurons, such as their synaptic organization and their cellular properties, remain largely unknown. Our major goal in this proposal is to identify the cell-specific cellular and synaptic mechanisms that determine how L5 corticocollicular and L5 corticocallosal neurons - L5 principal neurons projecting to contralateral cortex - differentially process synaptic and acoustic input. The proposed experimental program will provide fundamental new information about the synaptic, cellular, and microcircuit properties of corticocollicular and corticocallosal L5 neurons. We expect that our findings will establish a new framework for understanding the roles of A1 projection neurons in top-down corticocollicular modulation of auditory processing in normal and disease states, such as in tinnitus and in pathological sound and speech perception.
描述(由申请人提供):从初级听觉皮层(A1)到听觉脑干的自上而下的皮质通路有力地调节听觉加工。一个重要的自上而下的通路是由皮质丘神经元介导的:A1层(L) 5锥体神经元的一个子集具有远程轴突投射到下丘(IC)。皮质-丘投影形成IC神经元的反应特性,并介导声音定位学习。然而,先前关于A1皮质机制的生理学研究并没有专门针对皮质丘神经元。因此,基本生理特性

项目成果

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Gordon M Shepherd其他文献

Gordon M Shepherd的其他文献

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{{ truncateString('Gordon M Shepherd', 18)}}的其他基金

Towards a neurobiology of "oromanual" motor control: behavioral analysis and neural mechanisms
走向“手动”运动控制的神经生物学:行为分析和神经机制
  • 批准号:
    10819032
  • 财政年份:
    2023
  • 资助金额:
    $ 32.72万
  • 项目类别:
Bidirectional circuits of locus ceruleus and motor cortex neurons
蓝斑和运动皮层神经元的双向回路
  • 批准号:
    10447235
  • 财政年份:
    2022
  • 资助金额:
    $ 32.72万
  • 项目类别:
Developing new paradigms for mouse forelimb sensorimotor circuit analysis
开发小鼠前肢感觉运动电路分析的新范例
  • 批准号:
    10371764
  • 财政年份:
    2021
  • 资助金额:
    $ 32.72万
  • 项目类别:
Towards elucidation of circuit mechanisms for feeding-related manual dexterity
阐明与喂养相关的手动灵巧性的电路机制
  • 批准号:
    9982480
  • 财政年份:
    2020
  • 资助金额:
    $ 32.72万
  • 项目类别:
Brainstem circuits of corticospinal neurons
皮质脊髓神经元的脑干回路
  • 批准号:
    9977340
  • 财政年份:
    2020
  • 资助金额:
    $ 32.72万
  • 项目类别:
In Vivo Analysis of Cortical Projection Neurons
皮质投射神经元的体内分析
  • 批准号:
    8816156
  • 财政年份:
    2014
  • 资助金额:
    $ 32.72万
  • 项目类别:
Cellular Mechanisms Underlying Corticocollicular Modulation in the Auditory Syste
听觉系统中皮质小丘调节的细胞机制
  • 批准号:
    8827754
  • 财政年份:
    2014
  • 资助金额:
    $ 32.72万
  • 项目类别:
Synaptic Circuit Organization of Motor Cortex
运动皮层的突触电路组织
  • 批准号:
    8632022
  • 财政年份:
    2008
  • 资助金额:
    $ 32.72万
  • 项目类别:
Synaptic Circuit Organization of Motor Cortex
运动皮层的突触电路组织
  • 批准号:
    8303317
  • 财政年份:
    2008
  • 资助金额:
    $ 32.72万
  • 项目类别:
Synaptic Circuit Organization of Motor Cortex
运动皮层的突触电路组织
  • 批准号:
    10451517
  • 财政年份:
    2008
  • 资助金额:
    $ 32.72万
  • 项目类别:

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