Centralized Research Instrumentation Core (CRI)

项目摘要 PR-INBRE集中式研究仪器（CRI）核心的总体目标是 整合和授权学院的研究人员，学生和博士后从铅，小学 本科院校（PUI）和外展机构，通过提供导师和 科学支持。PR-INBRE CRI将包括PR-INBRE支持的核心设施， 美国国立卫生研究院（NIH）基础设施支持的其他合作设施 国家少数民族健康和健康差异研究所（NIMHD）资助的项目 波多黎各大学医学科学校区（UPR-MSC）RCMI计划，并与UPR 机构资金。其中一些核心设施已经运营了14年或更长时间， M.S.博士-水平经验丰富的技术人员和致力于科研人员。以下 在下一个周期，设施将参与拟议的CRI：RCMI/PR-INBRE人类 遗传学和基因组学核心实验室在UPR-MSC; PR-INBRE代谢组学核心在UPR- UPR里奥皮德拉斯的PR-INBRE测序和基因组学设施 Ana G.大学的ChEMTox Biotesting核心。门德斯Cupey校园和公关- INBRE/RCMI翻译蛋白质组学核心在UPR综合癌症中心。他们的 努力支持地方、国家和国际合作。为了实现这一总体目标， 提出了以下具体目标：1）继续提供获得最新技术的机会 核心研究仪器，以培育新的研究项目和扩大已建立的 国际研究所研究人员、学生和来自波多黎各的博士后之间的研究合作 和其他IDEA国家。2)确保有效传播国际空间研究所提供的技术 通过理论和实践研讨会，指导研究人员进行实验设计， 利用CRI核心资源的数据分析和最佳做法。第三章 与其他INBRE和COBRE核心实验室合作，扩大PR-INBRE的访问权限 研究人员了解其他IDEA核心可用的创新技术，并提供机会 通过支持参加以下活动，促进技术和科学工作人员的专业发展： 专业会议，如生物医学研究设施协会（ABRF）和 其他培训机会。协助发展跨学科研究工作 在PR-INBRE网络机构中，CRI将提供专门服务，例如： 在遗传学实验设计、数据生成和分析方面提供技术咨询， 人类和小动物模型系统中的基因组学，蛋白质组学，代谢组学和生物学 在细菌和组织培养细胞中测试实验化合物。

Project Summary The overall goal of the PR-INBRE Centralized Research Instrumentation (CRI) Cores is to integrate and empower Faculty investigators, students and postdocs from the Lead, Primarily Undergraduate Institutions (PUIs), and Outreach Institutions by providing mentorship and scientific support. The PR-INBRE CRI will incorporate core facilities supported by PR-INBRE and other collaborating facilities supported by National Institutes of Health (NIH) infrastructure programs such as the National Institute on Minority Health and Health Disparities (NIMHD)-funded University of Puerto Rico Medical Sciences Campus (UPR-MSC) RCMI program, and with UPR institutional funds. Several of these core facilities have been operating for 14 or more years with M.S. and Ph.D.-level experienced technicians and committed scientific staff. The following facilities will participate in the proposed CRI in the next cycle: the RCMI/PR-INBRE Human Genetics and Genomics Core Lab at UPR-MSC; the PR-INBRE Metabolomics Core at UPR- MSC; the PR-INBRE Sequencing and Genomics Facility at UPR-Rio Piedras; the PR-INBRE ChEMTox Biotesting Core at Universidad Ana G. Mendez Cupey Campus and the PR- INBRE/RCMI Translational Proteomics Core at the UPR-Comprehensive Cancer Center. Their efforts support local, national and international collaborations. To fulfill the overall goal of this Core the following specific aims are proposed: 1) Continue to provide access to state-of-the-art core research instrumentation for nurturing new research projects and expanding established research collaborations between the CRI investigators, students, and postdocs from Puerto Rico and other IDeA states. 2) Ensure the effective dissemination of technologies offered by the CRI Cores via theoretical and practical workshops, mentoring researchers in experimental design, data analysis and best practices in the use of the resources available at the CRI Cores. 3) Collaborate with other INBRE and COBRE Core labs to expand access for PR-INBRE investigators to innovative technologies available at other IDeA cores and provide opportunities for professional development of technical and scientific staff by supporting attendance to professional meetings such as the Association of Biomedical Research Facilities (ABRF) and other training opportunities. To assist in the development of an interdisciplinary research effort at the PR-INBRE network institutions, the CRI will provide specialized services such as: direct technical consultation on experimental design, data generation, and analysis in genetics and genomics in human and small animal model systems, proteomics, metabolomics, and biological testing of experimental compounds in bacteria and tissue culture cells.