Improving Remote Breathalyzer Procedures used by Clinicians and Researchers to Remotely Monitor Alcohol Use

改进临床医生和研究人员用于远程监测酒精使用情况的远程呼吸分析仪程序

• 批准号: 10452357
• 负责人: Donald M Dougherty
• 金额: $ 22.84万
• 依托单位: UNIVERSITY OF NORTH TEXAS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452357
• 关键词: Abstinence; Adopted; Adoption; Alcohol consumption; Alcohols; Area; Behavior Therapy; Biological Markers; Blood; Blood alcohol level measurement; Blood specimen; Breath Tests; Clinical; Clinical Research; Data; Detection; Devices; Disadvantaged; Effectiveness; Event; Face; Failure; Forensic Medicine; Frequencies; Future; Gold; Health Technology; Heavy Drinking; Hour; Incentives; Individual; Intervention; Manufacturer Name; Measurement; Measures; Methods; Monitor; Motivation; National Institute on Alcohol Abuse and Alcoholism; Participant; Pattern; Periodicity; Persons; Physical activity; Procedures; Protocols documentation; Public Health; Reporting; Research; Research Personnel; Sampling; Secure; Skin; Sleep; Specificity; Spottings; Strategic Planning; Testing; Text Messaging; Time; Violence; Waiting Lists; Work; alcohol measurement; alcohol monitoring; base; breath alcohol measurement; clinical practice; contingency management; cost; drinking; driving under influence; dual diagnosis; handheld mobile device; improved; liver transplantation; offender; phosphatidylethanol; recruit; remote monitoring; secondary analysis; social stigma; wearable sensor technology

Project Summary/Abstract The availability of wearable biosensors that continuously and/or remotely monitor alcohol use is increasing and has created new opportunities for research and intervention in clinical practice and forensic settings. Our previous work in this area has focused on transdermal alcohol monitors, which remotely and continuously monitor alcohol excreted through the skin. While such devices, like Secure Continuous Remote Alcohol Monitors, have been validated and found reliable, they have some disadvantages that limit widespread adoption including availability, cost, size, interference with physical activities, and stigma. One alternative is the use of breathalyzers that remotely sample and report breath alcohol levels across the day. These are becoming the preferred method for monitoring alcohol use in settings where continuous monitoring for alcohol consumption is required. Although remote breathalyzers are accurate for detecting current blood alcohol levels and identifying the individual providing the sample through facial recognition, their primary limitation could be the failure to detect drinking when monitoring is absent during the "off- cycle”; the 10 hours between early 9pm and 6am when heavy alcohol use could occur. Individuals who have difficulty remaining abstinent and may adopt a pattern of drinking during “off-cycle” periods to avoid the negative consequences associated with positive breath samples. We propose that current practices for remote alcohol breath monitoring in research, clinical, and judicial settings are inadequate to detect drinking. Specifically, we aim to evaluate the accuracy of remote breath alcohol monitoring to detect drinking events; and determine if drinking undetected by remote breath alcohol monitoring can be identified by phosphatidylethanol measurement. We expect that breath alcohol monitoring (and infrequent blood spot sampling) will be more acceptable than transdermal alcohol monitoring. This work challenges current practices by providing evidence of “off-cycle” drinking (Aim 1) and will improve existing methods by validating remote breath testing plus periodic measures of phosphatidylethanol (Aim 2). We also will determine the optimal frequency of phosphatidylethanol measurements to confidently confirm abstinence or identify those who may be motivated to adopt patterns of drinking to avoid detection and consequences (Aim 2). This work will help redefine remote alcohol-use monitoring procedures and significantly improve clinical, forensic and research practices.

项目总结/摘要 持续和/或远程监测酒精使用的可穿戴生物传感器的可用性是 增加，并创造了新的机会，研究和干预临床实践和法医 设置.我们以前在这一领域的工作主要集中在透皮酒精监测器上， 持续监测通过皮肤排出的酒精。虽然这样的设备，如安全连续 远程酒精检测器已经过验证并被发现是可靠的，但它们有一些缺点， 广泛采用，包括可用性，成本，大小，对身体活动的干扰和耻辱。一 另一种方法是使用呼气测醉器，远程采样并报告一天中的呼气酒精水平。 这些正在成为监测酒精使用的首选方法， 需要对酒精消费进行监测。虽然远程呼气测醉器可以准确检测 当前血液酒精水平并通过面部识别识别提供样本的个人， 它们的主要限制可能是在“关闭”期间没有监测时无法检测到饮酒， 周期”;晚上9点到早上6点之间的10个小时，这是可能发生大量饮酒的时间。的个人 很难保持禁欲，可能会采取在“非周期”期间饮酒的模式，以避免 与阳性呼吸样本相关的负面后果。我们建议， 研究、临床和司法环境中的远程酒精呼气监测不足以检测饮酒。 具体来说，我们的目标是评估远程呼吸酒精监测检测饮酒事件的准确性; 并确定通过远程呼吸酒精监测未检测到的饮酒是否可以被识别， 磷脂酰乙醇测量。我们希望呼吸酒精监测（和罕见的血斑 采样）将比透皮酒精监测更可接受。这项工作挑战了当前 通过提供“非周期”饮酒的证据（目标1）来改进现有方法， 验证远程呼吸测试加上磷脂酰乙醇的定期测量（目标2）。我们也将 确定磷脂酰乙醇测量的最佳频率，以确信地确认禁欲，或 确定那些可能有动机采取饮酒模式以避免被发现和后果的人 (Aim 2）的情况。这项工作将有助于重新定义远程酒精使用监测程序， 临床、法医和研究实践。