Consequences of Substance Use on the Development of Impulse Control

物质使用对冲动控制发展的影响

• 批准号: 10400331
• 负责人: Donald M Dougherty
• 金额: $ 0.95万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-15 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10400331
• 关键词: 12 year old; Adolescence; Adolescent Development; Adolescent and Young Adult; Affect; Assessment tool; Automobile Driving; Behavior; Biological Models; Biosensor; Clinical Research; Complex; Data; Data Analyses; Data Collection; Development; Developmental Process; Environmental Risk Factor; Esthesia; Family; Family history of; Internships; Knowledge; Lead; Longitudinal Studies; Modeling; Monitor; National Institute of Drug Abuse; National Institute of Mental Health; Outcome; Paper; Parents; Participant; Prevention program; Process; Provider; Recording of previous events; Research; Research Design; Risk; Risk-Taking; Severities; Strategic Planning; Substance Use Disorder; Testing; Training; United States National Institutes of Health; Work; Writing; Youth; base; data management; design; disorder control; emerging adult; experience; parent grant; preadolescence; programs; resilience; skills; social factors; substance use; substance use treatment; summer research; training opportunity; undergraduate student; young adult

Project Summary/Abstract The parent grant is a longitudinal study designed to elucidate mechanisms driving the initiation and progression of substance use is consistent with NIDA and NIMH's recently outlined strategic plans (NIDA, 2016; NIH CRAN, 2015; NIMH, 2015) prioritizing research on the period between adolescence and young adulthood. Defining features of typical adolescent development are increases in sensation seeking followed by more gradual increases in impulse control (described by the Dual Systems model). The discrepancy between developing sensation seeking and impulse control are theorized to result in risk-taking behaviors like substance use. In at-risk youth, these developmental processes may be further discrepant, which may be one mechanism for increased rates and severity of substance use involvement. This renewal project has been documenting the relationship of sensation seeking and impulse control since before substance use onset (10 to 12 years old at study entry), and this renewal will continue to assess these processes and outcomes into young adulthood. More specifically, we continue longitudinal assessments (every 6 months) of our at-risk (due to family history of substance use disorder) and control youth to monitor changes in substance use, impulse control, environmental, sensation seeking, risk and resiliency factors. Outcomes are interpreted from the perspective of the Dual Systems model, and importantly, this work will extend this model by testing: (1) whether impulse control and sensation seeking develop independently from one another; (2) whether impulse control and sensation seeking development has additive or interactive effects on substance use involvement; (3) how the onset and escalation of substance use affects subsequent development of impulse control and sensation seeking; (4) how processes identified in the Dual Systems model develop among adolescents and young adults with family history risk; and (5) how social and environmental factors influence risk and resiliency for substance use and are interpreted in the context of the Dual Systems model. Interpreting these findings within the context of the Dual Systems model will help to refine and extend the key premises of this model, as well as reveal more detail about developmental mechanisms of substance use involvement. As a part of this project, we offer a training opportunity for the 2021 NIDA Summer Research Internship Program. We will provide participants in this internship program with training in (1) clinical research in substance use; (2) assessment of substance use including advanced assessment tools using biosensors as well as conventional paper-based assessment; (3) data entry and management; and (4) academic writing and presentations on the topic of substance use disorder.

项目概要/摘要 家长资助是一项纵向研究，旨在阐明驱动启动和 物质使用的进展与 NIDA 和 NIMH 最近概述的战略计划一致（NIDA、 2016年；美国国立卫生研究院克兰，2015； NIMH，2015）优先研究青春期和年轻时期 成年期。典型青少年发展的定义特征是感觉寻求的增加，然后是 脉冲控制的逐渐增加（由双系统模型描述）。之间的差异 从理论上讲，发展感觉寻求和冲动控制会导致冒险行为，例如 物质的使用。在高危青少年中，这些发育过程可能会进一步出现差异，这可能是其中之一 增加物质使用参与率和严重程度的机制。本次更新项目已 记录自物质使用开始之前以来感觉寻求和冲动控制的关系（10 到进入研究时 12 岁），本次更新将继续评估这些过程和结果 年轻的成年期。更具体地说，我们继续对我们的风险（由于 物质使用障碍家族史）并控制青少年监测物质使用、冲动的变化 控制、环境、感觉寻求、风险和弹性因素。结果的解释来自 双系统模型的视角，重要的是，这项工作将通过测试扩展该模型：（1） 冲动控制和感觉寻求是否相互独立地发展； (2)是否冲动 控制和感觉寻求发展对物质使用参与具有累加或交互作用； (3) 物质使用的开始和升级如何影响冲动控制的后续发展和 寻求感觉； (4) 双元系统模型中确定的过程如何在青少年和青少年中发展 有家族史风险的年轻人； (5) 社会和环境因素如何影响风险和弹性 物质使用，并在双系统模型的背景下进行解释。解释这些发现 在双系统模型的背景下将有助于完善和扩展该模型的关键前提，如 并揭示有关物质使用参与的发展机制的更多细节。 作为该项目的一部分，我们为 2021 年 NIDA 夏季研究实习提供培训机会 程序。我们将为本次实习项目的参与者提供（1）临床研究方面的培训 物质使用； (2) 物质使用评估，包括使用生物传感器作为先进评估工具 以及传统的纸质评估； （三）数据录入和管理； (4) 学术写作和 关于物质使用障碍主题的演讲。

项目成果

Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol.

• DOI: 10.1002/brb3.615
• 发表时间: 2017-02
• 期刊: Brain and behavior
• 影响因子: 3.1
• 作者: Acheson A;Wijtenburg SA;Rowland LM;Winkler A;Mathias CW;Hong LE;Jahanshad N;Patel B;Thompson PM;McGuire SA;Sherman PM;Kochunov P;Dougherty DM
• 通讯作者: Dougherty DM

Child Problems as a Moderator of Relations Between Maternal Impulsivity and Family Environment in a High-Risk Sample.

• DOI: 10.3109/10826084.2016.1168440
• 发表时间: 2016-08-23
• 期刊: Substance use & misuse
• 影响因子: 2
• 作者: Friedman CK;Ryan SR;Charles NE;Mathias CW;Acheson A;Dougherty DM
• 通讯作者: Dougherty DM

Functional activation and effective connectivity differences in adolescent marijuana users performing a simulated gambling task.

• DOI: 10.1155/2015/783106
• 发表时间: 2015
• 期刊: Journal of addiction
• 作者: Acheson A;Ray KL;Hines CS;Li K;Dawes MA;Mathias CW;Dougherty DM;Laird AR
• 通讯作者: Laird AR

The age-varying effects of adolescent stress on impulsivity and sensation seeking.

• DOI: 10.1111/jora.12854
• 发表时间: 2023-05
• 期刊: Journal of research on adolescence : the official journal of the Society for Research on Adolescence
• 作者: A. Wasserman;Erin E. Wood;C. Mathias;T. Moon;N. Hill-Kapturczak;J. Roache;D. Dougherty

Family Functioning as a Mediator of Relations between Family History of Substance Use Disorder and Impulsivity.

• DOI: 10.1097/adt.0000000000000070
• 发表时间: 2016-03
• 期刊: Addictive disorders & their treatment
• 影响因子: 1.1
• 作者: Ryan SR;Friedman CK;Liang Y;Lake SL;Mathias CW;Charles NE;Acheson A;Dougherty DM
• 通讯作者: Dougherty DM