Core F: Neuropathology Core

核心 F：神经病理学核心

• 批准号: 10454257
• 负责人: Elizabeth Head
• 金额: $ 59.78万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454257
• 关键词: Aging; Alzheimer’s disease biomarker; Autopsy; Biological Markers; Biometry; Brain; Clinical; Collection; Communities; Data; Dementia; Diagnosis; Dissection; Down Syndrome; Education; Enrollment; Ensure; Equipment and supply inventories; Family; Freezing; Goals; Guidelines; Image; Individual; Infrastructure; Institutes; Kentucky; Letters; Liquid substance; Magnetic Resonance Imaging; Measures; Neurofibrillary Tangles; Outcome; Participant; Persons; Process; Protocols documentation; Research; Research Personnel; Research Support; Resources; Sampling; Scanning; Ships; Site; Slide; Specimen; Standardization; Tissue Banks; Tissue Sample; Tissues; Translations; Universities; alpha synuclein; biobank; brain tissue; cerebrovascular pathology; cohort; data management; digital pathology; in vivo; in vivo imaging; neuroimaging; neuroinflammation; neuropathology; novel; prospective; protein TDP-43; quantitative imaging; repository; research study; symposium; virtual; whole slide imaging

Neuropathology Core Abstract The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes, provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will 1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.

神经病理学核心摘要 神经病理学核心(NP)的目标是通过系统地支持DS的衰老和痴呆的研究 从临床特征性脑尸检中收集、鉴定和传播组织 参与者参加了ABC-DS。ABC-DS研究的NP核心部分将提供最终的 神经病理学诊断，进行死后磁共振成像，获得高质量的组织用于研究目的， 为传播组织、神经病理和成像数据提供基础设施，并与所有 ABC-DS中的岩心。除了新收集的大脑，在研究的头两年，NP Core将 描述遗留的尸检病例队列(n=65)，以填补神经病理学数据的空白并获得新的 结果。核电厂核心将提供支持项目1、2和3的关键数据。尸检成像数据 将有助于以系统的方式将活体成像转化为神经病理学。因此，NP核心将 1)开发脑部尸检网络，2)提供神经病理诊断，并为生物统计学提供数据 和数据管理核心；3)作为组织储存库和传播组织样本；4)获取和 共享整个幻灯片量化数字病理学，以支持项目1、2和3；5)获取尸检 神经成像，以弥合体内和体外尸检研究之间的差距。