Core F: Neuropathology Core
核心 F:神经病理学核心
基本信息
- 批准号:10454257
- 负责人:
- 金额:$ 59.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AgingAlzheimer’s disease biomarkerAutopsyBiological MarkersBiometryBrainClinicalCollectionCommunitiesDataDementiaDiagnosisDissectionDown SyndromeEducationEnrollmentEnsureEquipment and supply inventoriesFamilyFreezingGoalsGuidelinesImageIndividualInfrastructureInstitutesKentuckyLettersLiquid substanceMagnetic Resonance ImagingMeasuresNeurofibrillary TanglesOutcomeParticipantPersonsProcessProtocols documentationResearchResearch PersonnelResearch SupportResourcesSamplingScanningShipsSiteSlideSpecimenStandardizationTissue BanksTissue SampleTissuesTranslationsUniversitiesalpha synucleinbiobankbrain tissuecerebrovascular pathologycohortdata managementdigital pathologyin vivoin vivo imagingneuroimagingneuroinflammationneuropathologynovelprospectiveprotein TDP-43quantitative imagingrepositoryresearch studysymposiumvirtualwhole slide imaging
项目摘要
Neuropathology Core Abstract
The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically
collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized
participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final
neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes,
provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all
cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will
characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel
outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data
will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will
1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics
and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and
share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem
neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.
神经病理学核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elizabeth Head其他文献
Elizabeth Head的其他文献
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{{ truncateString('Elizabeth Head', 18)}}的其他基金
T21RS Meeting June 2022 Long Beach, California
T21RS 会议 2022 年 6 月 加利福尼亚州长滩
- 批准号:
10469127 - 财政年份:2022
- 资助金额:
$ 59.78万 - 项目类别:
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
他克莫司在阿尔茨海默病犬模型中的临床前评价
- 批准号:
10198086 - 财政年份:2017
- 资助金额:
$ 59.78万 - 项目类别:
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
他克莫司在阿尔茨海默病犬模型中的临床前评价
- 批准号:
10446042 - 财政年份:2017
- 资助金额:
$ 59.78万 - 项目类别:
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