Core F: Neuropathology Core
核心 F:神经病理学核心
基本信息
- 批准号:10454257
- 负责人:
- 金额:$ 59.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-30 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AgingAlzheimer’s disease biomarkerAutopsyBiological MarkersBiometryBrainClinicalCollectionCommunitiesDataDementiaDiagnosisDissectionDown SyndromeEducationEnrollmentEnsureEquipment and supply inventoriesFamilyFreezingGoalsGuidelinesImageIndividualInfrastructureInstitutesKentuckyLettersLiquid substanceMagnetic Resonance ImagingMeasuresNeurofibrillary TanglesOutcomeParticipantPersonsProcessProtocols documentationResearchResearch PersonnelResearch SupportResourcesSamplingScanningShipsSiteSlideSpecimenStandardizationTissue BanksTissue SampleTissuesTranslationsUniversitiesalpha synucleinbiobankbrain tissuecerebrovascular pathologycohortdata managementdigital pathologyin vivoin vivo imagingneuroimagingneuroinflammationneuropathologynovelprospectiveprotein TDP-43quantitative imagingrepositoryresearch studysymposiumvirtualwhole slide imaging
项目摘要
Neuropathology Core Abstract
The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically
collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized
participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final
neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes,
provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all
cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will
characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel
outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data
will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will
1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics
and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and
share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem
neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.
神经病理学核心摘要
神经病理学核心(NP)的目标是通过系统地支持DS的衰老和痴呆的研究
从临床特征性脑尸检中收集、鉴定和传播组织
参与者参加了ABC-DS。ABC-DS研究的NP核心部分将提供最终的
神经病理学诊断,进行死后磁共振成像,获得高质量的组织用于研究目的,
为传播组织、神经病理和成像数据提供基础设施,并与所有
ABC-DS中的岩心。除了新收集的大脑,在研究的头两年,NP Core将
描述遗留的尸检病例队列(n=65),以填补神经病理学数据的空白并获得新的
结果。核电厂核心将提供支持项目1、2和3的关键数据。尸检成像数据
将有助于以系统的方式将活体成像转化为神经病理学。因此,NP核心将
1)开发脑部尸检网络,2)提供神经病理诊断,并为生物统计学提供数据
和数据管理核心;3)作为组织储存库和传播组织样本;4)获取和
共享整个幻灯片量化数字病理学,以支持项目1、2和3;5)获取尸检
神经成像,以弥合体内和体外尸检研究之间的差距。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elizabeth Head其他文献
Elizabeth Head的其他文献
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{{ truncateString('Elizabeth Head', 18)}}的其他基金
T21RS Meeting June 2022 Long Beach, California
T21RS 会议 2022 年 6 月 加利福尼亚州长滩
- 批准号:
10469127 - 财政年份:2022
- 资助金额:
$ 59.78万 - 项目类别:
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
他克莫司在阿尔茨海默病犬模型中的临床前评价
- 批准号:
10198086 - 财政年份:2017
- 资助金额:
$ 59.78万 - 项目类别:
Preclinical evaluation of tacrolimus in a canine model of Alzheimer's disease
他克莫司在阿尔茨海默病犬模型中的临床前评价
- 批准号:
10446042 - 财政年份:2017
- 资助金额:
$ 59.78万 - 项目类别:
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