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Core F: Neuropathology Core

核心 F：神经病理学核心

基本信息

批准号：
10667587
负责人：
Elizabeth Head
金额：
$ 58.03万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10667587
关键词：
Acceleration Aging Alzheimer’s disease biomarker Autopsy Biological Markers Biometry Brain Clinical Collection Communities Data Dementia Diagnosis Dissection Down Syndrome Education Ensure Equipment and supply inventories Family Freezing Goals Guidelines Image Individual Infrastructure Kentucky Letters Liquid substance Magnetic Resonance Imaging Measures National Institute on Alcohol Abuse and Alcoholism Neurofibrillary Tangles Outcome Participant Persons Process Protocols documentation Research Research Personnel Research Support Resources Sampling Scanning Site Slide Specimen Standardization Tissue Banks Tissue Sample Tissues Translations Universities alpha synuclein biobank brain tissue cerebrovascular pathology cohort data management digital pathology in vivo in vivo imaging neuroimaging neuroinflammation neuropathology novel participant enrollment prospective protein TDP-43 quantitative imaging repository research study symposium virtual whole slide imaging

项目摘要

Neuropathology Core Abstract The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes, provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will 1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.

神经病理学核心摘要神经病理学核心（NP）的目标是通过系统地支持DS中衰老和痴呆的研究。从临床表征的脑尸检中收集、表征和传播组织参加ABC-DS。ABC-DS研究的NP核心部分将提供最终的神经病理学诊断，执行死后MR成像，获得用于研究目的的高质量组织，为组织、神经病理学和成像数据的传播提供基础设施， ABC-DS中的核心。除了新收集的大脑，在研究的前两年，NP Core将表征尸检病例的遗留队列（n=65），以填补神经病理学数据的空白，并获得新的结果。NP Core将提供关键数据来支持项目1、2和3。死后的影像资料将有助于以系统的方式将体内成像转化为神经病理学。因此，NP Core将 1)发展脑解剖网络，2）提供神经病理学诊断，并为生物统计学提供数据和数据管理核心; 3）作为组织和传播组织样本的储存库; 4）获取和共享全切片定量数字病理学，以支持项目1、2和3; 5）获取尸检神经影像学的桥梁之间的差距差距在体内和离体尸检研究。