Core F: Neuropathology Core

核心 F：神经病理学核心

• 批准号: 10667587
• 负责人: Elizabeth Head
• 金额: $ 58.03万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667587
• 关键词: Acceleration; Aging; Alzheimer’s disease biomarker; Autopsy; Biological Markers; Biometry; Brain; Clinical; Collection; Communities; Data; Dementia; Diagnosis; Dissection; Down Syndrome; Education; Ensure; Equipment and supply inventories; Family; Freezing; Goals; Guidelines; Image; Individual; Infrastructure; Kentucky; Letters; Liquid substance; Magnetic Resonance Imaging; Measures; National Institute on Alcohol Abuse and Alcoholism; Neurofibrillary Tangles; Outcome; Participant; Persons; Process; Protocols documentation; Research; Research Personnel; Research Support; Resources; Sampling; Scanning; Site; Slide; Specimen; Standardization; Tissue Banks; Tissue Sample; Tissues; Translations; Universities; alpha synuclein; biobank; brain tissue; cerebrovascular pathology; cohort; data management; digital pathology; in vivo; in vivo imaging; neuroimaging; neuroinflammation; neuropathology; novel; participant enrollment; prospective; protein TDP-43; quantitative imaging; repository; research study; symposium; virtual; whole slide imaging

Neuropathology Core Abstract The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes, provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will 1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.

神经病理学核心