T21RS Meeting June 2022 Long Beach, California

项目概要/摘要 唐氏综合症（DS）是由三个而不是预期的两个染色体拷贝遗传引起的 21或21三体。DS的特征是大脑中特定的结构异常，一系列认知功能障碍， 缺陷和智力残疾，以及在中年时发展阿尔茨海默病的显著高风险。 在过去十年中，DS研究的快速进展突出了以下方面的迫切需要： 科学家、临床医生、家庭和自我倡导者之间的有效沟通， 从实验室到临床试验的发现，使DS患者受益。DS研究的进展不是 这是由资深科学家推动的，但也依赖于我们下一代年轻科学家的培养。 因此，这项申请要求提供资金，以支付美国初级调查员的差旅费， 博士后研究员和研究生参加第四届21世纪三体国际会议 研究学会（T21 RS）。出席本次会议的人员将包括已成立的DS和非DS研究者 其研究直接或间接地为DS认知、神经病理学、翻译 机会和临床试验。会议将于6月8日至6月12日在加州的长滩举行， 2022.基于我们以往的成功，我们预计这次会议将导致富有成果的讨论， 新的合作是必不可少的定义未来的DS研究。我们会议的主题是 想象，发现，探索。

PROJECT SUMMARY/ABSTRACT Down syndrome (DS) is caused by the inheritance of three rather than the expected two copies of chromosome 21, or trisomy 21. DS is characterized by specific structural abnormalities in the brain, by a range of cognitive deficits and intellectual disability, and by a significantly high risk of developing Alzheimer disease by middle age. The rapid pace of progress in DS research that has taken place in the last decade highlights the critical need for effective communication between scientists, clinicians, families and self-advocates to take basic research discoveries from the laboratory to clinical trials that benefit people with DS. Advances in DS research are not only driven by senior scientists but are dependent up on the nurturing of our next generation of junior scientists. Thus, this application requests funding to cover travel expenses of American-based junior investigators, postdoctoral fellows and graduate students to attend the Fourth International conference of the Trisomy 21 Research Society (T21RS). Attendees at this meeting will include established DS and non-DS investigators whose research directly or indirectly informs critical aspects of DS cognition, neuropathology, translational opportunities and clinical trials. The meeting will take place in Long Beach, California from June 8 to June 12, 2022. Based on our previous successes, we anticipate that this conference will lead to fruitful discussions and novel collaborations that are essential to define the future of DS research. The theme of our meeting will be Imagine, Discover, Inspire.