Neuroscience, Immunology, Social Adversity and the Roots of Addictive Behaviors: Toward a New Framework for Drug Use Etiology and Prevention

神经科学、免疫学、社会逆境和成瘾行为的根源：建立药物使用病因学和预防的新框架

• 批准号: 10454994
• 负责人: Steven R Beach
• 金额: $ 207.71万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454994
• 关键词: Addictive Behavior; Adolescence; Affect; African American; African American population; Behavior; Behavioral; Biological; Buffers; Centers of Research Excellence; Childhood; Chronic; Chronic stress; Communities; Consultations; Consumption; Data; Development; Discipline; Drug abuse; Drug usage; Eating; Economics; Emotions; Etiology; Exposure to; Family; Fatty acid glycerol esters; Food; Fostering; Funding; Generations; Immune; Immunology; Inflammation; Infrastructure; Intervention; Investigation; Low income; Mentors; Modeling; National Institute of Drug Abuse; Neurobiology; Neurocognitive; Neuroimmune; Neuroimmunomodulation; Neurosciences; Participant; Peripheral; Persons; Physiological; Pilot Projects; Plant Roots; Population; Poverty; Prevention; Prevention program; Preventive; Process; Provider; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Resource-limited setting; Resources; Risk; Science; Scientist; Skin; Specific qualifier value; Stress; System; Testing; Training; Transact; Underrepresented Populations; United States National Institutes of Health; Work; Youth; cardiometabolic risk; career; caregiving; connective tissue-activating peptide; contextual factors; data-driven model; design; drug abuse prevention; drug use vulnerability; emotion regulation; ethnic minority; evidence base; experience; health disparity; image processing; imaging facilities; innovation; member; minority communities; multilevel analysis; network models; neural circuit; next generation; prevention evaluation; programs; ranpirnase; resilience; social adversity; social influence; sugar; supportive environment; theories; tool

PROJECT SUMMARY: Overall Center The Center for Translational and Prevention Science (CTAPS; P20 MH068666, P30 DA027827) has been funded continuously since 2003 to advance next-generation basic and preventive investigations of risk, resilience, and drug use among African American young people living in resource poor communities in the southeastern US. CTAPS has pioneered research demonstrating how exposures to economic and social adversity promote drug use through their effects on neurobiological and peripheral systems. Of particular importance, research sponsored by CTAPS also has demonstrated the promise of family-centered drug use prevention programming in shielding young people from these neurobiological risks. At present, transformative progress in the prevention of addictive behavior among populations exposed to chronic stress has been hampered significantly by the lack of (a) integrative theoretical frameworks that generate hypotheses regarding the risk and resilience mechanisms that connect social adversity to addictive behavior and cardiometabolic risk, (b) infrastructures that can collect model driven data on multiple neurocognitive, peripheral biological, and behavioral systems associated with chronic stress, and (c) transdisciplinary teams that can integrate these data into the design and evaluation of prevention programs. The theoretical framework of the proposed P50 Research Center of Excellence is a next generation, neuroimmune network (NIN) model that CTAPS scientists developed to better describe the ways in which exposure to social adversity predispose young people to the onset and escalation of diverse forms of addictive behaviors. The NIN model specifies stress-induced alterations in the transactions between peripheral inflammation and neurocognitive systems that subserve emotion regulation in the development of addictive behavior vulnerability. As a P50 Center, we propose to build on and expand CTAPS’ pioneering work on (a) the biological and neurocognitive contributors to addictive behaviors that drive many drug use and health disparities African Americans’ experience and (b) the potential of family-centered prevention programming to ameliorate the influence of growing up in chronically stressful contexts. We will leverage an established team of investigators from diverse disciplines and an established infrastructure for testing transdisciplinary hypotheses. This infrastructure includes efficient, established pipelines connecting P50 research project (RP) and pilot study investigators to intellectual resources, wet labs, a state-of-the-science imaging facility, and a world class platform for processing imaging data. We will implement three innovative, thematically integrated RPs. RPs, innovative pilot projects, an expanded national resource system, and investigator development activities will be supported through our infrastructure system composed of a Research Support Core, an Administrative Core, and a Pilot Core. CTAPS activities will have wide-reaching implications for research, practice, and prevention concerning drug use and cardiometabolic risk in low-income and ethnic minority communities. 1

项目总结：整体中心 翻译和预防科学中心(CTAPS；P20 MH068666，P30 DA027827) 自2003年以来不断提供资金，以推进下一代基本和预防性风险调查， 复原力和生活在资源贫乏社区的非裔美国年轻人中的药物使用 美国东南部。CTAPS率先进行了一项研究，展示了经济和社会风险敞口如何 逆境通过对神经生物学和外周系统的影响促进药物的使用。特别的 重要的是，由CTAPS赞助的研究也证明了以家庭为中心的药物使用的前景 保护年轻人免受这些神经生物学风险的预防规划。目前，变革性的 在慢性应激人群中预防成瘾行为的进展 严重受阻于：(A)缺乏综合的理论框架来产生关于以下方面的假设 将社会逆境与成瘾行为和心脏代谢风险联系起来的风险和弹性机制， (B)可收集多种神经认知、外周生物学和模型驱动数据的基础设施 与慢性压力相关的行为系统，以及(C)可以整合这些数据的跨学科团队 纳入预防方案的设计和评估。拟议P50的理论框架 卓越研究中心是CTAPS科学家的下一代神经免疫网络(NIN)模型 旨在更好地描述暴露在社会逆境中的方式使年轻人容易受到 各种形式的成瘾行为的开始和升级。NIN模型指定了应力诱导 外周炎症和神经认知系统之间的交易的变化 情绪调节在成瘾行为发展中的易感性。作为P50中心，我们建议建立 关于并扩展CTAPS关于(A)成瘾的生物和神经认知因素的开创性工作 导致许多吸毒和健康差距的行为非裔美国人的经历和(B)潜在的 以家庭为中心的预防规划，以改善在长期应激环境中成长的影响 上下文。我们将利用来自不同学科的成熟的调查团队和成熟的 测试跨学科假设的基础设施。这一基础设施包括高效、成熟的 将P50研究项目(RP)和先导研究调查人员连接到智力资源、湿实验室、 最先进的成像设备，以及处理成像数据的世界级平台。我们会 实施三个创新的、主题整合的RPS。RPS，创新试点项目，扩大国家 资源系统和调查员开发活动将通过我们的基础设施系统得到支持 由研究支持核心、管理核心和试点核心组成。CTAPS活动将有 对药物使用和心脏代谢风险的研究、实践和预防的广泛影响 在低收入和少数民族社区。 1