EMERGE PHASE III CLINICAL CENTER AT PARTNERS HEALTHCARE

PARTNERS HEALTHCARE 新兴三期临床中心

• 批准号: 9284512
• 负责人: ELIZABETH W KARLSON
• 金额: $ 91.62万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284512
• 关键词: Algorithms; Alleles; Area; Asthma; Attention deficit hyperactivity disorder; Bioinformatics; Biology; Bipolar Disorder; CTLA4 gene; Callback; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Data; Clinical Trials; Complex; Computerized Medical Record; Congestive Heart Failure; Consent; Coronary Arteriosclerosis; Coronary heart disease; Cost Effectiveness Analysis; Custom; DRD2 gene; Data; Disease; Enrollment; Family member; Funding; Genes; Genetic; Genomic medicine; Genotype; Goals; HLA-DRB1; Health Personnel; Healthcare; Immune; Individual; Inflammatory Bowel Diseases; Informatics; Intervention; LDL Cholesterol Lipoproteins; LDLR gene; Laboratories; Learning; Low-Density Lipoproteins; Machine Learning; Mediating; Medical; Medicine; Mental Depression; Mining; Movement; Multiple Sclerosis; Mutation; New England; Newborn Infant; Outcome; Participant; Pathogenicity; Patients; Penetrance; Pharmaceutical Preparations; Pharmacogenetics; Phase; Phenotype; Physicians; Population; Population Attributable Risks; Protocols documentation; Public Health; Research; Rheumatoid Arthritis; Schizophrenia; Source; Stream; Stroke; Surveys; TCF7L2 gene; TNFRSF1A gene; TYK2; Testing; Variant; Visit; arm; base; biobank; biomarker panel; clinical care; clinical practice; clinical sequencing; clinically actionable; cost; cost effective; design; exome; experience; genetic analysis; genetic information; genetic variant; hypercholesterolemia; implementation research; loss of function; neuropsychiatric disorder; neuropsychiatry; novel; pilot trial; pleiotropism; premature; public health relevance; randomized trial; rare variant; support tools

 DESCRIPTION (provided by applicant): The eMERGE III Clinical Center proposal from Partners HealthCare leverages a large biobank, clinical data in the electronic medical records (EMR) for >4 million participants from the largest integrated health care provider in New England, advanced bioinformatics expertise and state-of-the-art genetic analysis. We propose three aims. (1) Aim 1. Discovery. We will test the hypothesis that common and rare variants from a custom chip including 50,000 loss of function (LoF) alleles will be associated with cardiovascular, neuropsychiatric and immune-mediated phenotypes derived from the EMR. We are currently genotyping 25,000 Partners HealthCare Biobank subjects with a custom chip that includes LoF alleles from 63,000 exomes that we have analyzed. (2) Aim 2. Penetrance and Pleiotropy. We will test the hypothesis that sequencing a set of established genes or loci will allow us to discover additional variation, and define penetrance and pleiotropy using EMR phenotypes. Rare variants in genes selected by the eMERGE network will be studied for penetrance and pleiotropic outcomes by PheWAS and chart review. In addition, we are poised to perform recall-by-genotype studies because all Biobank participants have provided consent for such callback. (3) Aim 3. Implementation. We will test the hypothesis that physicians will alter their surveillance and treatment of patients based upon voluntary return of actionable variants to provide safe and cost-effective benefits to patients. We will screen our entire Biobank population of 25,000 individuals for pathogenic variants in the LDLR gene, the leading genetic cause of premature coronary artery disease, and conduct an exploratory trial in disclosing this information. Biobank participants with pathogenic variants in LDLR will be offered enrollment into a randomized trial, in which their finding will be CLIA-confirmed, and in one arm, this result will be communicated to their physicians through the EMR. Over one year, we will collect the following outcomes through participant surveys and EMR queries: physician visits, laboratory testing, changes in medication prescriptions, LDL levels, medical costs and the number of family members screened and treated as a result of the intervention. We will collaborate with the entire eMERGE III Network to incorporate what we learn from this pilot trial into large-scale implementation protocols for the genes selected by the Network for sequencing. Finally, we will participate in all Network activities to enhance the movement of genetics into clinical practice.

 描述(由申请人提供)：来自合作伙伴Healthcare的Emerge III临床中心提案利用了大型生物库、电子病历(EMR)中的临床数据、来自新英格兰最大的综合医疗保健提供商的400万参与者、先进的生物信息学专业知识和最先进的基因分析。我们提出了三个目标。(1)目标1.发现。我们将测试这一假设，即来自定制芯片的常见和罕见变异包括50,000个功能丧失(LoF)等位基因，将与来自EMR的心血管、神经精神和免疫介导的表型相关。我们目前正在使用一种定制芯片对25,000名合作伙伴医疗生物库受试者进行基因分型，该芯片包括我们已经分析的63,000个外显子的LoF等位基因。(2)目标2.外显性和多效性。我们将测试这样一种假设，即对一组已建立的基因或基因座进行测序将允许我们发现额外的变异，并使用EMR表型来定义外显性和多效性。由Emerge网络选择的基因中的罕见变异将通过Phewas和图表审查来研究外显性和多效性结果。此外，我们准备进行按基因召回的研究，因为所有Biobank参与者都同意进行此类召回。(3)目标3.实施。我们将检验这一假设，即医生将根据自愿返回的可操作变体来改变他们对患者的监测和治疗，以向患者提供安全和经济有效的好处。我们将对我们整个生物库进行筛选 对25,000人进行了LDLR基因致病变异的研究，LDLR基因是导致过早冠状动脉疾病的主要遗传原因，并进行了一项探索性试验，以揭示这一信息。带有LDLR致病变异的Biobank参与者将被提供参加一项随机试验，在该试验中，他们的发现将得到CLIA确认，在一只手臂中，这一结果将得到确认 将通过电子病历传达给他们的医生。在一年多的时间里，我们将通过参与者调查和EMR查询收集以下结果：医生就诊、实验室测试、药物处方变化、低密度脂蛋白水平、医疗费用以及因干预而筛查和治疗的家庭成员数量。我们将与整个Emerge III网络合作，将我们从这项试点试验中学到的东西纳入该网络选择进行测序的基因的大规模实施协议中。最后，我们将参与所有网络活动，以促进遗传学进入临床实践。