Microcircuits underlying murine parental behavior
Microcircuits underlying murine parental behavior
批准号:
10461107
负责人:
Catherine Dulac
金额:
$35.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2015
资助国家:
美国
项目状态:
未结题
起止时间:
2015-08-14 至 2025-07-31
关键词:
AdultAffectAggressive behaviorAgonistic BehaviorAnimalsArchitectureAreaAtlasesBehaviorBehavioralBiophysicsCalciumCaringCell NucleusCellsChild RearingDevelopmentDiagnosisDiagnosticDiseaseDissectionElectrophysiology (science)EndocrineFathersFemaleFunctional disorderFundingGalaninGene ExpressionGenetic TechniquesGenetic TranscriptionGoalsGrantHeadHormonalHormone ReceptorHumanHypothalamic structureImageImpairmentIn SituInfantInfant CareInfanticideLeadMajor Depressive DisorderMedialMediatingMental DepressionMolecularMolecular GeneticsMonitorMothersMotivationMotorMusNeural PathwaysNeuromodulator ReceptorsNeuronsPartner in relationshipPersonal SatisfactionPharmacologyPhysiologicalPopulationPreoptic AreasRegulationResolutionRoleSchizophreniaSliceSocial BehaviorSocial InteractionSpecificityStereotypingSynapsesSystemTherapeuticTranscriptional RegulationTranslatingVariantViralWorkaffiliative behaviorautism spectrum disorderbasebiophysical propertiesbiophysical techniquesburden of illnesscaregivingcell typeexperiencegenetic technologyimaging approachin vivoinnovationmalemicroendoscopemicroendoscopyneglectneural circuitneurobiological mechanismneuromechanismneurophysiologyneuroregulationnovelnovel therapeutic interventionoffspringpuprelating to nervous systemsevere mental illnesssexsocialsocial deficitstherapeutic developmenttoolurocortin
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
Many severe mental disorders with considerable disease burden such Autism Spectrum Disorders,
Schizophrenia, and Major Depressive Disorder are characterized by profound social impairments. At present,
there is little understanding of the origin of these social deficits, and efficient diagnosis and therapeutic options
are lacking. Advanced molecular and genetic techniques make the discovery of specific neural circuits involved
in social behavior possible, facilitating the development of diagnostics and novel therapeutic approaches specific
to disorders with social deficits. We have taken advantage of newly developed molecular, genetic and systems-
levels tools to uncover how specific neural populations and circuits involved in parental care, a social behavior
essential for the survival and well-being of the offspring are regulated according to the animal sex and
physiological status. Male and female mice show either affiliative or agonistic behavior toward infants depending
on prior social experience. In recent work, we uncovered distinct subpopulations of hypothalamic neurons that
are involved in the positive and negative regulation of male and female parenting behavior. The identification of
these cell types with high granularity provides us with unique entry point to further dissect how changes in the
molecular, biophysical and activity dynamics of distinct neuronal populations regulates parental care. We
propose here to exploit the precise cell type identification of neuronal populations involved in the control of
opposing infant-mediated behaviors and use high resolution molecular (Aim 1), neurophysiological (Aim 2) and
systems-level (Aim 3) approaches to dissect the entire circuitry associated with infant-directed social interactions
and to explore how these circuits are modulated by the animal’s sex and physiological state.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Odor trail tracking: a new paradigm to unveil algorithms and neural circuits underlying active sensation and continuous decision making
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批准号:10524245
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项目类别:
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资助金额:$273.03万
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财政年份:2022
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负责人:Catherine Dulac
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依托单位:
Molecular and genetic dissection of brain circuits controlling fever
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批准号:10373051
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项目类别:
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资助金额:$39.2万
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财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate Behavior
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批准号:10709855
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项目类别:
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资助金额:$141.98万
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财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Molecular and genetic dissection of brain circuits controlling fever
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批准号:10589104
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项目类别:
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资助金额:$39.2万
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财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
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批准号:10678954
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项目类别:
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资助金额:$130.0万
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财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
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批准号:10269034
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项目类别:
-
资助金额:$130.0万
-
财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Center for Integrated Multi-modal and Multi-scale Nucleome Research
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批准号:10458025
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项目类别:
-
资助金额:$130.0万
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财政年份:2020
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负责人:Catherine Dulac
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依托单位:
Microcircuits underlying murine parental behavior
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批准号:10227959
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项目类别:
-
资助金额:$35.61万
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财政年份:2015
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负责人:Catherine Dulac
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依托单位:
Microcircuits underlying murine parental behavior
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批准号:9751346
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项目类别:
-
资助金额:$35.07万
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财政年份:2015
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负责人:Catherine Dulac
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依托单位:
Microcircuits underlying murine parental behavior
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批准号:10674853
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项目类别:
-
资助金额:$35.61万
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财政年份:2015
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负责人:Catherine Dulac
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依托单位:
Microcircuits underlying murine parental behavior
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批准号:8961097
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项目类别:
-
资助金额:$35.07万
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财政年份:2015
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:9011941
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项目类别:
-
资助金额:$35.91万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:8803784
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项目类别:
-
资助金额:$35.55万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:9231422
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项目类别:
-
资助金额:$35.91万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:8480443
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项目类别:
-
资助金额:$35.91万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:8639517
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项目类别:
-
资助金额:$35.91万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
Sensory processing of social and defensive chemosignals
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批准号:8915270
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项目类别:
-
资助金额:$7.0万
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财政年份:2013
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负责人:Catherine Dulac
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依托单位:
The role of an olfactory-specific histone variant in olfactory development
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批准号:7976559
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项目类别:
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资助金额:$21.0万
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财政年份:2010
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负责人:Catherine Dulac
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依托单位:
The role of an olfactory-specific histone variant in olfactory development
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批准号:8103897
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项目类别:
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资助金额:$24.39万
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财政年份:2010
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负责人:Catherine Dulac
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依托单位:
Genetic analysis of brain circuits underlying pheromone signaling
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批准号:7877971
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项目类别:
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资助金额:$35.34万
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财政年份:2009
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负责人:Catherine Dulac
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依托单位:
海外基金