Photoacoustic imaging and artificial intelligence-based theranostic approach for cancer

基于光声成像和人工智能的癌症治疗诊断方法

• 批准号: 10081458
• 金额: $ 41.67万
• 依托单位: ASCEND TECHNOLOGIES LIMITED
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10081458
• 关键词: Photoacoustic; imaging; artificial; intelligence; based

Health programs crave for diagnostic imaging and eradication of chemoresistant neoplastic lesions smaller than 1 mm of size. PHIRE, based on the outcomes from EDIT (FET-OPEN-RIA, GA#801126), aims at bringing closer to market a novel high-resolution theranostic medical device effective in the clinical applications for lesions <1 mm, ready for application in human bladder cancer and effective both in male and female patients.The PHIRE solution will be developed using swine model and will include:- an add-on module for pre-existing off-the shelf photoacoustic device allowing to perform photoacoustic imaging of hollow organs located deeper in human body, designed to be used in combination with- an artificial intelligence-assisted prediction map for the image-guided gold nanorods assisted photo-thermal therapy,- a large-scale synthesis of urine-stable gold nanorods for clinical use.The adoption for clinical applications of this new device will reduce the frequency of the bladder tumor relapse and the number of patients with relapsing tumor, with a drastic positive impact on the quality of life of patients while reducing the social cost of the management of patients. Furthermore, PHIRE’s results will open up the way for the deployment of theranostic application against lesions <1 mm in other hollow human organs.PHIRE innovative solutions will also be applicable to other markets, such as that of photoacoustic and diagnostic imaging, gold nanoparticles, cystoscopy and medical software.

健康计划渴望诊断成像和根除小于1毫米大小的化疗耐药肿瘤病变。PHIRE基于EDIT(FET-OPEN-RIA，GA#801126)的结果，旨在使一种在病变和lt的临床应用中有效的新型高分辨率治疗医疗设备更接近市场；PHIRE解决方案将使用猪模型开发，并将包括：-用于预先存在的现成光声设备的附加模块，允许对位于人体更深处的中空器官执行光声成像，其设计用于与-用于图像引导的金纳米棒辅助光热疗法的人工智能辅助预测地图，-用于临床的尿液稳定金纳米棒的大规模合成。这种新装置的临床应用将减少膀胱肿瘤复发的频率和肿瘤复发患者的数量，对患者的生活质量产生巨大的积极影响，同时降低患者管理的社会成本。此外，PHIRE的结果将为在其他中空人体组织中部署针对1毫米病变的声学应用开辟道路。PHIRE创新的解决方案也将适用于其他市场，如光声和诊断成像、金纳米粒子、膀胱镜和医疗软件。