Photoacoustic imaging and artificial intelligence-based theranostic approach for cancer

健康项目渴望诊断成像和根除小于1毫米的化疗耐药肿瘤病变。基于EDIT （FET-OPEN-RIA, GA#801126）的结果，PHIRE旨在将一种新型的高分辨率治疗性医疗设备推向市场，该设备可用于<1 mm病变的临床应用，可用于人类膀胱癌，对男性和女性患者均有效。PHIRE解决方案将使用猪模型开发，并将包括：-预先存在的现成光声设备的附加模块，允许对位于人体深层的空心器官进行光声成像，设计用于结合-用于图像引导金纳米棒辅助光热疗法的人工智能辅助预测图，-用于临床使用的尿稳定金纳米棒的大规模合成。该装置的临床应用将降低膀胱肿瘤复发的频率和肿瘤复发患者的数量，对患者的生活质量产生巨大的积极影响，同时降低患者管理的社会成本。此外，PHIRE的结果将为在其他空心人体器官中针对< 1mm病变的治疗应用开辟道路。PHIRE的创新解决方案也将适用于光声和诊断成像、金纳米颗粒、膀胱镜检查和医疗软件等其他市场。

Health programs crave for diagnostic imaging and eradication of chemoresistant neoplastic lesions smaller than 1 mm of size. PHIRE, based on the outcomes from EDIT (FET-OPEN-RIA, GA#801126), aims at bringing closer to market a novel high-resolution theranostic medical device effective in the clinical applications for lesions <1 mm, ready for application in human bladder cancer and effective both in male and female patients.The PHIRE solution will be developed using swine model and will include:- an add-on module for pre-existing off-the shelf photoacoustic device allowing to perform photoacoustic imaging of hollow organs located deeper in human body, designed to be used in combination with- an artificial intelligence-assisted prediction map for the image-guided gold nanorods assisted photo-thermal therapy,- a large-scale synthesis of urine-stable gold nanorods for clinical use.The adoption for clinical applications of this new device will reduce the frequency of the bladder tumor relapse and the number of patients with relapsing tumor, with a drastic positive impact on the quality of life of patients while reducing the social cost of the management of patients. Furthermore, PHIRE’s results will open up the way for the deployment of theranostic application against lesions <1 mm in other hollow human organs.PHIRE innovative solutions will also be applicable to other markets, such as that of photoacoustic and diagnostic imaging, gold nanoparticles, cystoscopy and medical software.