2022 Hemostasis Gordon Research Conference and Seminar

项目总结/摘要 我们请求部分支持止血戈登研究研讨会（GRS）和戈登研究 会议（GRC），2022年7月31日至8月5日，在沃特维尔谷，NH。2022年止血GRC是第35届 该系列会议被广泛认为是止血领域的首要科学会议， 血栓形成研究。这一重要主题与NIH在两个关键领域的战略目标密切相关：1） 了解止血和血栓性疾病的机制并降低发病率和死亡率， 包括中风、心肌梗死、静脉血栓栓塞和创伤诱导的凝血病，以及2） 增加生物医学研究人员。此外，最近的研究表明， 认为止血系统具有比凝血更广泛的重要性，在炎症中起作用，先天性 免疫、肥胖、糖尿病和癌症。止血GRS/GRC汇集了感兴趣的研究人员， 凝血蛋白和血小板的生物学、生物化学和遗传学;治疗出血的医生 和血栓性疾病，制药公司的科学家开发新的止血疗法， 疾病，以及致力于止血和 血栓形成这些研究人员一起讨论最先进的研究并探索新的研究 止血和血栓形成的机会及其在医学相关领域的应用。事实上，许多关键 该领域的进展已经在先前的止血GRCs上首次亮相。国际知名科学家参与 通过密切互动和互动交流，激励学员和初级研究人员。免费 所有与会者之间的思想交流和未发表的研究是我们GRS/GRC的关键。此外，优先事项是 妇女、代表性不足的人口、身体残疾者和青年的参与 研究人员，包括研究生和博士后学员，以及初级教师。2022年止血GRS是 专门致力于通过培训生发展增强生物医学研究队伍的目标 活动和指导GRS由学员组织和管理。它非常成功，并提高了 在GRC的学员的个人资料。2022年止血GRC计划包括两个主题演讲 非常成功的科学家，博士罗伯特蒙哥马利和爱德华犁，39会谈，和海报。8口， 4个海报会议重点关注的主题包括凝血：信号传导和结构;凝血和血小板生成素 炎症;维持止血平衡;凝块和深静脉血栓形成结构; 以血液为食的生物的分子止血作用;慢性疾病中的凝血和血小板减少; 以及出血和凝血控制。重要的是，我们将继续举办“热点话题”会议， 由8名学员介绍他们的工作。

Project Summary/Abstract We request partial support for the Hemostasis Gordon Research Seminar (GRS) and Gordon Research Conference (GRC), July 31-August 5, 2022, in Waterville Valley, NH. The 2022 Hemostasis GRC is the 35th meeting in this series which is widely considered as the premier scientific meeting for hemostasis and thrombosis research. This important topic closely aligns with NIH strategic goals in two critical areas: 1) to understand mechanisms and reduce morbidity and mortality from hemostatic and thrombotic diseases, including stroke, myocardial infarction, venous thromboembolism, and trauma-induced coagulopathy and 2) to increase the biomedical research workforce. Furthermore, recent research has shown that the traditionally considered hemostatic system has wider importance beyond clotting, playing roles in inflammation, innate immunity, obesity, diabetes, and cancer. The Hemostasis GRS/GRC brings together researchers interested in the biology, biochemistry, and genetics of blood clotting proteins and platelets; physicians treating bleeding and thrombotic diseases, scientists from pharmaceutical companies developing new therapies for hemostatic disorders, and trainees and junior faculty who are committed to research careers in hemostasis and thrombosis. Together, these investigators discuss state-of-the-art research and explore new research opportunities in hemostasis and thrombosis and their applications in medically related fields. Indeed, many key advances in this field have debuted at previous Hemostasis GRCs. Internationally renowned scientists engage and motivate trainees and junior investigators through close interactions and interactive exchanges. Free exchange of ideas and unpublished research, among all attendees, is a key to our GRS/GRC. Also, a priority is participation by women, underrepresented populations, individuals with physical disabilities, and young investigators, including graduate and postdoctoral trainees, and junior faculty. The 2022 Hemostasis GRS is specifically dedicated to the goal of enhancing the biomedical research workforce through trainee development activities and mentoring The GRS is organized and run by trainees. It is highly successful and enhances the profile of trainees at the GRC. The 2022 Hemostasis GRC program includes keynote addresses from two highly successful scientists, Drs. Robert Montgomery and Edward Plow, 39 talks, and posters. The 8 oral and 4 poster sessions focus on topics including Coagulation: Signaling and Structure; Coagulation and Platelets in Inflammation; Maintaining Hemostatic Balance; Clot and Deep Vein Thrombosis Structure; Lessons of Molecular Hemostasis from Organisms that Feed on Blood; Coagulation and Platelets in Chronic Diseases; and Bleeding and Clotting Control. Importantly, we will continue the practice of holding a “Hot Topics” session of abstract-derived talks during which 8 trainees present their work.