Dictyostelium Community Resource

项目总结 盘基网柄菌群落资源(DCR)是一个为使用盘基网柄菌的研究者提供的综合资源 以及用于生物医学研究和培训的相关物种。DCR整合了之前单独资助的两个 资源，DictyBase，模式生物数据库和Dicty Stock Center，菌株和材料 收集竹鞭毛虫，打造全面的社区资源。DCR是一种 计算和物理资源-各有不同的角色，但共享基础设施和用户客户端。 考虑到它们相关和相互关联的目标，两者的这种集成提高了效率，使用户能够 从同一组织获取经过整理的信息和研究材料。广泛支持的DCR 由研究界提供黄金标准的专家文献基因、功能注释 使用基因本体论和广泛的基因组资源在直观和易于搜索的在线 资源。网柄苔藓被广泛用于研究细胞运动、趋化、信号等细胞过程。 转导、细胞对药物的反应和宿主与病原体的相互作用。网柄网柄菌的基因组包含 脊椎动物、酵母和微生物基因的重要同源物，吸引了研究人员对各种各样的兴趣 生物学主题，包括人类疾病、多细胞分化和比较基因组学。DCR 使研究人员能够搜索、查看和下载最新的基因组、功能和技术信息。它 由于有丰富的可用教材和研究，也被教师/教师广泛使用 协议。Dictyostatus调查人员依赖DictyBase作为他们的主要社区资源，在那里有帮助 可以从DictyBase工作人员(DCR帮助热线)或其他用户(Dicty Listserv，由DCR主持)获得。 我们正处于部署我们的全新技术堆栈的最后阶段。到今年年底，DictyBase 将完全作为基于云的应用程序运行。本提案寻求对该公司运营和扩张的支持 重要的社区资源。我们对这项提议的目标是：(目标1)支持调查人员社区 利用盘基网柄菌及相关物种，(目标2)提供盘基网柄菌及相关物种的科学管理 对于调查员群体，(目标3)维持和分发菌种收集；(目标4)扩大覆盖范围 关于物种和菌株；(目标5)改进DCR的可及性和实用性。这种支持将建立在美国国立卫生研究院的基础上 通过充分整合和改进资源，为资源提供资金。

PROJECT SUMMARY The Dictyostelium Community Resource (DCR) is an integrated resource for investigators using Dictyostelium and related species for biomedical research and training. The DCR integrates two previously separately funded resources, dictyBase, the model organism database and the Dicty Stock Center, the strain and materials collection for Dictyostelids, to create a comprehensive community resource. The DCR is a combination of a computational and physical resource - each with separate roles but sharing infrastructure and user clientele. Given their related and interconnected goals, this integration of the two promotes efficiency, allowing users to obtain both curated information and research materials from the same organization. The DCR, widely supported by the research community, provides gold standard expert literature curation of genes, functional annotations using the Gene Ontology and a wide range of genomic resources in an intuitive and readily searchable online resource. Dictyostelium is widely used to study cellular processes such as cell motility, chemotaxis, signal transduction, cellular response to drugs, and host-pathogen interactions. Dictyostelium's genome contains significant orthologs of vertebrate, yeast and microbial genes, attracting researchers interested in a wide variety of biological topics including human disease, multicellular differentiation and comparative genomics. The DCR enables researchers to search, view and download up-to-date genomic, functional and technical information. It is also widely used by teachers/instructors due to the wealth of available teaching materials and research protocols. Dictyostelium investigators depend on dictyBase as their primary community resource, where help from dictyBase staff (DCR help line) or from other users (Dicty ListServ, moderated by the DCR) is available. We are in the final stages of deploying our completely new technology stack. By the end of this year dictyBase will be run entirely as a cloud-based application. This propoal seeks support the operation and expansion of this important community resource. Our goals for this proposal are: (Aim 1) Support the community of investigators using Dictyostelium and related species, (Aim 2) Provide scientific curation of D.discoideum and related species for community of investigators, (Aim 3) Maintain and distribute the strain collection; (Aim 4) Expand the Coverage of Species and Strains; (Aim 5) Improve Accessibility and Utility of the DCR. This support would build upon NIH funded resources by fully integrating and improving them.