Dictyostelium Community Resource

盘基网柄菌社区资源

• 批准号: 10024726
• 负责人: REX L CHISHOLM
• 金额: $ 80.81万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10024726
• 关键词: Bar Codes; Biological; Biomedical Research; Birds; Caring; Cell physiology; Chemotaxis; Cloning; Collaborations; Collection; Communication; Communities; Data; Data Display; Data Storage and Retrieval; Dictyostelium; Dictyostelium discoideum; Disease; Electronic Mail; Equipment and supply inventories; Eukaryota; Eye; Family; Fostering; Funding; Genbank; Gene Proteins; Genes; Genetic; Genome; Genomics; Goals; Gold; Hour; Individual; Infrastructure; Internet; Intuition; Knowledge; Literature; Location; Maps; Methods; Mission; Modeling; Molecular; Newsletter; Nomenclature; Ontology; Organism; Orthologous Gene; Pathway interactions; Pharmaceutical Preparations; Phenotype; Plasmids; Procedures; Protocols documentation; Publications; Publishing; Quality Control; Records; Reference Standards; Research; Research Personnel; Research Support; Research Training; Resources; Role; Running; Secure; Ships; Signal Transduction; Site; Supervision; System; Taxonomy; Teaching Materials; Telephone; Time; Trust; United States National Institutes of Health; Update; Yeasts; base; cell motility; cloud based; comparative; comparative genomics; contig; dashboard; data curation; diverse data; expression vector; gene product; genome browser; human disease; improved; instructor; interest; microbial; model organisms databases; mutant; new technology; novel; online resource; operation; outreach; pathogen; preservation; reference genome; repository; response; search engine; teacher; tool; user-friendly

PROJECT SUMMARY The Dictyostelium Community Resource (DCR) is an integrated resource for investigators using Dictyostelium and related species for biomedical research and training. The DCR integrates two previously separately funded resources, dictyBase, the model organism database and the Dicty Stock Center, the strain and materials collection for Dictyostelids, to create a comprehensive community resource. The DCR is a combination of a computational and physical resource - each with separate roles but sharing infrastructure and user clientele. Given their related and interconnected goals, this integration of the two promotes efficiency, allowing users to obtain both curated information and research materials from the same organization. The DCR, widely supported by the research community, provides gold standard expert literature curation of genes, functional annotations using the Gene Ontology and a wide range of genomic resources in an intuitive and readily searchable online resource. Dictyostelium is widely used to study cellular processes such as cell motility, chemotaxis, signal transduction, cellular response to drugs, and host-pathogen interactions. Dictyostelium's genome contains significant orthologs of vertebrate, yeast and microbial genes, attracting researchers interested in a wide variety of biological topics including human disease, multicellular differentiation and comparative genomics. The DCR enables researchers to search, view and download up-to-date genomic, functional and technical information. It is also widely used by teachers/instructors due to the wealth of available teaching materials and research protocols. Dictyostelium investigators depend on dictyBase as their primary community resource, where help from dictyBase staff (DCR help line) or from other users (Dicty ListServ, moderated by the DCR) is available. We are in the final stages of deploying our completely new technology stack. By the end of this year dictyBase will be run entirely as a cloud-based application. This propoal seeks support the operation and expansion of this important community resource. Our goals for this proposal are: (Aim 1) Support the community of investigators using Dictyostelium and related species, (Aim 2) Provide scientific curation of D.discoideum and related species for community of investigators, (Aim 3) Maintain and distribute the strain collection; (Aim 4) Expand the Coverage of Species and Strains; (Aim 5) Improve Accessibility and Utility of the DCR. This support would build upon NIH funded resources by fully integrating and improving them.

项目摘要 网骨藻群落资源（DCR）是一个综合资源，供研究人员使用网骨藻 和相关物种的生物医学研究和培训。DCR整合了两个以前单独资助的 资源、dictyBase、模式生物数据库和Dicty Stock Center、菌株和材料 收集网柱虫，以创建一个全面的社区资源。DCR是一种 计算资源和物理资源-各自具有独立的角色，但共享基础设施和用户客户端。 考虑到它们的相关和相互关联的目标，两者的这种集成提高了效率，允许用户 从同一个组织获得策划的信息和研究材料。广受支持的DCR 由研究界提供基因、功能注释的黄金标准专家文献策展 使用基因本体和广泛的基因组资源，在一个直观的和容易搜索的在线 resource. Dictyosteoblastoma广泛用于研究细胞运动、趋化、信号转导等细胞过程 转导、细胞对药物的反应和宿主-病原体相互作用。网骨藻的基因组含有 脊椎动物，酵母和微生物基因的重要直系同源物，吸引了研究人员对各种各样的 生物学主题包括人类疾病，多细胞分化和比较基因组学。的DCR 使研究人员能够搜索、查看和下载最新的基因组、功能和技术信息。它 由于有丰富的教材和研究， 协议. Dictyosteoblasts研究人员依赖dictyBase作为他们的主要社区资源， 从字典库工作人员（DCR帮助线）或从其他用户（字典列表服务，由DCR主持）。 我们正处于部署全新技术堆栈的最后阶段。到今年年底，DictyBase 将完全作为基于云的应用程序运行。这一提议寻求支持的运作和扩大这一 重要的社区资源。我们这项提案的目标是：（目标1）支持研究人员社区 利用盘基网柄藻及其近缘种，（目的2）为盘基网柄藻及其近缘种的科学管理提供科学依据 对于研究者群体，（目标3）维护和分发菌株收集;（目标4）扩大覆盖范围 （目标5）提高DCR的可及性和实用性。这种支持将建立在国家卫生研究院 通过充分整合和改善这些资源来筹集资金。