Component for Institution # 269291

总结 目前的HIV-1大流行是一个艾滋病毒感染者（PWH）受到很好抑制的感染， 长期治疗。这引导研究关注（i）合并症（衰老， 心血管、癌症、代谢和免疫活化），（ii）ART的副作用，（iii）神经认知和 行为障碍（发生率约为40%），（iv）社会经济不平等，耻辱和 歧视、性和性别差异、人际关系和神经心理问题， （v）新的治疗方法和治愈策略。研究进展 这些不同的领域需要一种跨学科的方法， 和临床研究。为此，发展研究和指导核心的总体目标 （DRMC）是为神经艾滋病毒和艾滋病创新试点项目提供支持。艾滋病毒研究应对新出现的 科学优先事项和指导下一代艾滋病毒研究人员。DRMC将提供 为试点调查、进展评估、指导和辅导提供基础设施和支持。这一核心 申请书描述了当前资助期间的进展情况，核心董事的经验， 招募和审查创新项目申请的过程，以及核心将在指导 各级临床和基础科学教师和受训人员。在过去五年（6-10年级），19名（5名来自 费用分摊）奖励主要授予初级调查员。试点资金的获奖者一直非常 成功地发表了31篇手稿，并从与最近的试点赠款有关的研究中获得了9笔赠款。 在未来5年内，DRMC将每年资助6个试点应用。其中两个将由。DRMC 四是机构支持，以提供更优化的试点项目方案，并扩大我们的努力， 加强招聘和发展代表性不足的少数民族（URM）研究调查员。与 至于导师，短期目标是帮助初级，更高级的教师新的艾滋病毒，和URM教师 为试点研究基金制定一项成功的提案。长期目标是提供培训， 指导获奖者，将促进和加强他们的事业在neuroHIV到未来。DRMC将 提供一个组织和结构，将有效地整合新项目的开发， 初步研究，指导和建立新的跨学科合作。DRMC将工作 与中央行政和管理核心（CAMC）和科学核心密切合作， CNHC的研究重点和总体目标。预计这一核心将发挥关键作用 在加强和确保神经艾滋病毒调查人员的成功，扩大推广和支持URM， 推进神经HIV研究和CNHC使命的执行。

SUMMARY The current HIV-1 pandemic is one where people living with HIV (PWH) have had well-suppressed infection with therapy for prolonged periods of time. This has guided research towards focusing on (i) comorbidities (aging, cardiovascular, cancer, metabolic, and immune activation), (ii) side effects of ART, (iii) neurocognitive and behavioral disorders (occurs approximately 40% of time), (iv) socioeconomic inequalities, stigma and discrimination, sexual and gender disparities, interpersonal relations, and neuropsychological problems including depression across the PWH community, and (v) new therapeutics and cure strategies. Research advances in these diverse areas require an interdisciplinary approach with participation of investigators in basic, behavioral, and clinical research. Toward this end, the overall aim of the Developmental Research and Mentorship Core (DRMC) is to provide support for innovative pilot projects in neuroHIV and. HIV research addressing emerging scientific priorities and mentorship of the next generation of HIV researchers. The DRMC will provide infrastructure and support for pilot investigations, progress evaluation, guidance, and mentorship. This Core application describes the progress during the current funding period, experience of the Core Directors, the process to recruit and review innovative project applications, and the role the Core will play in mentorship of clinical and basic science faculty and trainees at various levels. In the last five years (years 6-10), 19 (5 from cost share) awards were given mostly to junior investigators. Awardees of pilot monies have been extremely successful with 31 published manuscripts and 9 grants awarded from research related to the recent pilot grants. Over the next 5-year period, the DRMC will fund six pilot applications per year. Two will be funded by the. DRMC and four from institutional support to provide a more optimal pilot project program and to expand our efforts to enhance the recruitment and development of underrepresented minority (URM) research investigators. With regards to mentorship, the short-term goal is to assist junior, more senior faculty new to HIV, and URM faculty in developing a successful proposal for pilot study funds. The long-term goal will be to provide training and mentorship to awardees that will foster and strengthen their careers in neuroHIV into the future. The DRMC will provide an organization and structure that will effectively integrate new project development, funding of preliminary research, mentorship and establishing new interdisciplinary collaborations. The DRMC will work closely with the Central Adminstrative and Management Core (CAMC) and scientific cores to promote high research priorities and overarching objectives of the CNHC. It is anticipated that this core will play a pivotal role in enhancing and ensuring the success of neuroHIV investigators, expand outreach and support of URM, and advance neuroHIV research and execution of the CNHC mission.