Interdisciplinary and Translational Research Training in NeuroHIV

摘要： 这一竞争性的续期申请为继续和进一步发展提供了一个计划， “跨学科和转化研究培训计划（ITRTP）在NeuroHIV”为博士前学生 研究HIV感染的中枢神经系统并发症及相关领域的研究。这是一 联合计划从两个机构，天普大学和德雷克塞尔大学，位于靠近 宾夕法尼亚州，费城。该计划还整合了培训活动和研究资源， 包括坦普尔大学和德雷克塞尔大学在内的神经艾滋病综合中心， 与艾滋病毒和神经病毒学临床研究培训计划的关系， 医学、微生物学和神经病学以及其他临床和基础科学部门和中心 艾滋病研究（CFAR）在宾夕法尼亚大学。我们正在进行的项目将继续发展 我们的全市跨学科和转化研究培训计划在神经艾滋病毒通过共享 资源，联合研讨会，讲习班，专题讨论会，邀请演讲者，以及论文指导和教育 坦普尔和德雷克塞尔都有活动这两个机构的研究生课程旨在 在生物医学科学，包括神经科学，免疫学， 微生物学、药理学和生理学。该课程包括负责任的研究行为， 科学交流，统计学，以及先进的课程，在分子和 细胞神经生物学、神经发病机制和转化神经科学。该计划汇集了 多个生物医学基础科学部门，并整合了两个相邻的联合培训活动 研究机构（Temple和Drexel）与位于以下地点的研究人员之间有着独特和长期的关系： 宾夕法尼亚大学紧邻德雷克塞尔纳入艾滋病毒临床治疗 翻译学生研究项目的调查员，以及坦普尔/德雷克塞尔CNAC基础科学和 临床核心设施大大增强了我们的培训计划，就其跨学科的性质。它还 使学生接触到基础科学和临床观点的相互关联，重点是HIV CNS 功能障碍、合并症（即衰老、药物滥用、合并感染病原体、癌症）、HIV疫苗 以及治疗和治愈HIV感染的新型神经保护和治疗策略 包括大脑在内的外周和储存库。我们的联合训练计划，连同我们的联合 通过我们的CNAC提供的基础设施资源，提供了强大的，互动的，非常成功的 在费城地区的神经病毒学和神经HIV的培训环境。以便支助和 加强我们在这个计划中代表性不足的少数民族的招聘，我们将继续提供夏季 医学生的实验室培训，以及卫生专业课程的学生，包括博士后， 为进入我们的博士学位提供途径。M.D.博士培训计划 神经艾滋病病毒

ABSTRACT: This competing renewal application provides a plan for the continuation and further development of the “Interdisciplinary and Translational Research Training Program (ITRTP) in NeuroHIV” for predoctoral students studying central nervous system (CNS) complications of HIV infection and related areas of research. This is a joint program from two institutions, Temple University and Drexel University, located in close proximity in Philadelphia, Pennsylvania. This program also integrates training activities and research resources available in the Comprehensive Center for NeuroAIDS (CNAC) involving both Temple and Drexel University and a relationship with the clinical research training programs in HIV and Neurovirology based in the Departments of Medicine, Microbiology, and Neurology as well as other clinical and basic science departments and the Center for AIDS Research (CFAR) at the University of Pennsylvania. Our ongoing program will continue to develop our citywide interdisciplinary and translational research training program in NeuroHIV through shared resources, joint seminars, workshops, symposia, invited speakers, as well as thesis mentoring and educational activities available at both Temple and Drexel. The graduate curriculum at both institutions is designed to provide a broad-based scientific foundation in biomedical sciences, including neuroscience, immunology, microbiology, pharmacology and physiology. This curriculum includes responsible conduct of research, scientific communication, statistics, as well as advanced courses with in-depth training in molecular and cellular neurobiology, neuropathogenesis, and translational neuroscience. This program brings together multiple biomedical basic science departments and integrates joint training activities at two neighboring institutions (Temple and Drexel) with unique and long-standing relationships between investigators located at the University of Pennsylvania positioned immediately adjacent to Drexel. Inclusion of access to clinical HIV investigators in translational student research projects, as well as Temple/Drexel CNAC basic science and clinical core facilities greatly enhances our training program with respect to its interdisciplinary nature. It also exposes students to the interrelatedness of basic sciences and clinical perspectives focusing on HIV CNS dysfunction, co-morbid conditions (i.e. aging, substance abuse, co-infecting pathogens, cancer), HIV vaccine and prevention strategies, and novel neuroprotective and therapeutic strategies to treat and cure HIV infection in the periphery and reservoirs including the brain. Our joint training program, together with our joint infrastructural resources available through our CNAC, provides a strong, interactive, and highly successful training environment in neurovirology and neuroHIV within the Philadelphia region. In order to support and enhance our under-represented minority recruitment within this program we will continue to provide summer laboratory training of medical students, and students in health professional programs including post- baccalaureate students that would provide pathways for entry into our Ph.D. and M.D./Ph.D. training program in NeuroHIV.