CORE CENTER FOR CLINICAL RESEACH IN TOTAL JOINT ARTHROPLASTY (CORE-TJA)

全关节置换术临床研究核心中心 (CORE-TJA)

• 批准号: 10477000
• 负责人: Daniel Berry
• 金额: $ 62.94万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-16 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10477000
• 关键词: Address; Adopted; Adoption; Advisory Committees; American; Area; Berry; Big Data; Biometry; Characteristics; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communication; Communities; Consultations; Custom; Data; Data Analyses; Data Collection; Data Element; Data Sources; Databases; Development; Disease; Documentation; Education; Electronic Health Record; Ensure; Environment; Epidemiology; Evaluation; Future; Goals; Health Services Research; Hip Prosthesis; Implant; Informatics; Information Technology; Infrastructure; Intervention; Intervention Studies; Joint Prosthesis; Knee Prosthesis; Leadership; Link; Medical Informatics; Methodology; Modeling; Musculoskeletal; Natural Language Processing; Observational Study; Operative Surgical Procedures; Outcome; Patient Care; Patients; Policies; Positioning Attribute; Procedures; Productivity; Registries; Replacement Arthroplasty; Research; Research Methodology; Research Personnel; Resources; Secure; Services; Surgeon; Technology; Time; Training; Translating; Translational Research; Translations; United States; Vision; analytical method; base; care outcomes; clinical center; cost; data registry; data resource; education resources; evidence base; experience; flexibility; improved; improved outcome; innovation; next generation; novel; outreach; programs; response; skills; tool; willingness

ABSTRACT - OVERALL Total joint arthroplasty (TJA) is the most common and fastest growing surgery in the nation. There are currently more than 7 million Americans living with artificial joints. Despite the high surgery volume, the evidence base for TJA procedures, technologies and associated interventions are limited. Many surgical approaches and implant technologies in TJA are adopted based on theoretical grounds with limited clinical evidence. The wider TJA research community needs access to large, high quality and rich data sources and state-of-the-art clinical research standards and information technologies to overcome methodological and practical challenges in studies of surgical and nonsurgical interventions in TJA. The overarching goal of Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) is to facilitate innovative, methodologically rigorous and interdisciplinary clinical research that will directly improve TJA care and the outcomes. The CORE-TJA will serve as a disease (TJA) and theme-focused Center providing shared methodological expertise, education and data resources. The CORE-TJA will leverage big data resources for TJA research, provide customized methodology resources in epidemiology, biostatistics, health services research and medical informatics, and establish synergistic interactions around an integrated Core (American Joint Replacement Registry – AJRR). The Specific Aims of CORE-TJA are: (1) To provide administrative and scientific oversight of CORE-TJA activities (Administrative Core), (2) To provide integrated services, access to large databases and novel analytical methods for clinical research in TJA (Methodology Core); and (3) To meet the unique data needs of the TJA research community and to strengthen the national capacity for large-scale observational and interventional studies in TJA using national registry data (Resource Core). The CORE-TJA will be integrated within the long-standing and highly centralized clinical research environment of the Mayo Clinic, thereby leveraging existing expertise and infrastructure resources, including the Center for Clinical and Translational Science. All CORE-TJA activities will be evaluated using robust metrics to ensure continuous evaluation, flexibility and improvement in response to the most pressing needs of the TJA research community.

摘要-总体 全关节置换术（TJA）是美国最常见和增长最快的手术。有 目前有超过700万美国人使用人工关节。尽管手术量很大， TJA程序、技术和相关干预措施的证据基础有限。许多外科 TJA中采用的方法和植入技术基于理论依据， 证据更广泛的TJA研究社区需要访问大型，高质量和丰富的数据源， 最先进的临床研究标准和信息技术，以克服方法和 TJA手术和非手术干预研究的实际挑战。马约的首要目标是 全关节置换术临床研究核心中心（CORE-TJA）旨在促进创新， 方法上严格和跨学科的临床研究，将直接改善TJA护理和 结果。CORE-TJA将作为一个疾病（TJA）和主题中心， 方法专门知识、教育和数据资源。核心TJA将利用大数据资源， TJA研究，提供流行病学，生物统计学，卫生服务方面的定制方法资源 研究和医学信息学，并围绕一个综合的核心（美国）建立协同互动 关节置换登记研究- AJRR）。 CORE-TJA的具体目标是：（1）对CORE-TJA进行行政和科学监督 （2）提供综合服务，进入大型数据库， TJA临床研究的分析方法（方法学核心）;（3）满足TJA独特的数据需求， 加强国家大规模观测能力， 使用国家登记数据进行的TJA干预性研究（资源核心）。CORE-TJA将被整合 在马约诊所的长期和高度集中的临床研究环境中， 利用现有的专业知识和基础设施资源，包括临床和翻译中心 科学所有CORE-TJA活动将使用可靠的指标进行评估，以确保持续评估， 灵活性和改进，以满足TJA研究界最迫切的需求。