CORE CENTER FOR CLINICAL RESEACH IN TOTAL JOINT ARTHROPLASTY (CORE-TJA)

全关节置换术临床研究核心中心 (CORE-TJA)

基本信息

批准号：
10703439
负责人：
Daniel Berry
金额：
$ 62.94万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10703439
关键词：
Acceleration Address Adopted Adoption Advisory Committees American Area Berry Big Data Biometry Caring Characteristics Clinic Clinical Clinical Data Clinical Research Clinical Sciences Collaborations Communication Communities Consultations Data Data Analyses Data Collection Data Element Data Sources Databases Development Disease Documentation Education Electronic Health Record Ensure Environment Epidemiology Evaluation Future Goals Health Services Research Hip Prosthesis Implant Informatics Information Technology Infrastructure Institution Intervention Intervention Studies Joint Prosthesis Knee Prosthesis Leadership Link Medical Informatics Methodology Modeling Musculoskeletal Natural Language Processing Observational Study Operative Surgical Procedures Outcome Patient Care Patients Policies Positioning Attribute Procedures Productivity Registries Replacement Arthroplasty Research Research Methodology Research Personnel Resources Secure Services Surgeon Technology Time Training Translating Translational Research Translations United States Vision analytical method clinical center cost data registry data resource education resources evidence base experience flexibility improved improved outcome innovation next generation novel outreach programs response skills tool willingness

项目摘要

ABSTRACT - OVERALL Total joint arthroplasty (TJA) is the most common and fastest growing surgery in the nation. There are currently more than 7 million Americans living with artificial joints. Despite the high surgery volume, the evidence base for TJA procedures, technologies and associated interventions are limited. Many surgical approaches and implant technologies in TJA are adopted based on theoretical grounds with limited clinical evidence. The wider TJA research community needs access to large, high quality and rich data sources and state-of-the-art clinical research standards and information technologies to overcome methodological and practical challenges in studies of surgical and nonsurgical interventions in TJA. The overarching goal of Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) is to facilitate innovative, methodologically rigorous and interdisciplinary clinical research that will directly improve TJA care and the outcomes. The CORE-TJA will serve as a disease (TJA) and theme-focused Center providing shared methodological expertise, education and data resources. The CORE-TJA will leverage big data resources for TJA research, provide customized methodology resources in epidemiology, biostatistics, health services research and medical informatics, and establish synergistic interactions around an integrated Core (American Joint Replacement Registry – AJRR). The Specific Aims of CORE-TJA are: (1) To provide administrative and scientific oversight of CORE-TJA activities (Administrative Core), (2) To provide integrated services, access to large databases and novel analytical methods for clinical research in TJA (Methodology Core); and (3) To meet the unique data needs of the TJA research community and to strengthen the national capacity for large-scale observational and interventional studies in TJA using national registry data (Resource Core). The CORE-TJA will be integrated within the long-standing and highly centralized clinical research environment of the Mayo Clinic, thereby leveraging existing expertise and infrastructure resources, including the Center for Clinical and Translational Science. All CORE-TJA activities will be evaluated using robust metrics to ensure continuous evaluation, flexibility and improvement in response to the most pressing needs of the TJA research community.

摘要 - 总体总关节置换术（TJA）是全国最常见，最快的手术。有目前，超过700万的美国人拥有人造关节。尽管手术量很高，但 TJA程序，技术和相关干预措施的证据基础受到限制。许多手术根据临床有限的理论理由采用了TJA中的方法和植入技术证据。更广泛的TJA研究社区需要访问大型，高质量和丰富的数据源，并且最先进的临床研究标准和信息技术，以克服方法论和在TJA的手术和非手术干预研究中，实际挑战。梅奥的总体目标总关节置换术（Core-TJA）的临床研究核心中心是促进创新的，在方法论上严格和跨学科的临床研究，将直接改善TJA护理和结果。 Core-TJA将充当疾病（TJA）和以主题为中心的中心提供共享方法论专业知识，教育和数据资源。 Core-TJA将利用大数据资源 TJA研究，提供流行病学，生物统计学，卫生服务的定制方法论资源研究和医疗信息，并围绕综合核心（美国）建立协同互动联合置换注册表 - AJRR）。 Core-TJA的具体目的是：（1）提供对Core-TJA的行政和科学监督活动（行政核心），（2）提供集成服务，访问大型数据库和新颖 TJA临床研究的分析方法（方法核心）；（3）满足独特的数据需求 TJA研究社区，并增强国家大规模观察能力和使用国家注册表数据（资源核心）中的TJA进行介入研究。 Core-TJA将集成在梅奥诊所的长期且高度集中的临床研究环境中利用现有的专业知识和基础设施资源，包括临床和翻译中心科学。所有核心-TJA活动将使用强大的指标进行评估，以确保持续评估，响应TJA研究社区最紧迫的需求的灵活性和改进。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Primary and Revision Total Knee Arthroplasty in Patients With Pulmonary Hypertension: High Perioperative Mortality and Complications.

DOI：
10.1016/j.arth.2021.07.005
发表时间：
2021-11
期刊：
JOURNAL OF ARTHROPLASTY
影响因子：
3.5
作者：
Baker, Courtney E.;Chalmers, Brian P.;Taunton, Michael J.;Kremers, Hilal Maradit;Amundson, Adam W.;Berry, Daniel J.;Abdel, Matthew P.
通讯作者：
Abdel, Matthew P.

Nuts and Bolts of Patient-Reported Outcomes in Orthopaedics.

骨科患者报告结果的具体细节。

DOI：
10.1016/j.arth.2022.11.011
发表时间：
2023
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Lee,MinjiK;Zaniletti,Isabella;Larson,DirkR;Lewallen,DavidG;Berry,DanielJ;MaraditKremers,Hilal
通讯作者：
MaraditKremers,Hilal

Demystifying Statistics and Machine Learning in Analysis of Structured Tabular Data.

揭秘结构化表格数据分析中的统计和机器学习。

DOI：
10.1016/j.arth.2023.08.045
发表时间：
2023
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Khosravi,Bardia;Weston,AlexanderD;Nugen,Fred;Mickley,JohnP;MaraditKremers,Hilal;Wyles,CodyC;Carter,RickeyE;Taunton,MichaelJ
通讯作者：
Taunton,MichaelJ

Immortal Time Bias in the Analysis of Time-to-Event Data in Orthopedics.

DOI：
10.1016/j.arth.2021.06.012
发表时间：
2021-10
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Larson DR;Crowson CS;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H
通讯作者：
Maradit Kremers H

Adjusted Survival Curves Improve Understanding of Multivariable Cox Model Results.

DOI：
10.1016/j.arth.2021.06.002
发表时间：
2021-10
期刊：
The Journal of arthroplasty
影响因子：
0
作者：
Lundgreen CS;Larson DR;Atkinson EJ;Devick KL;Lewallen DG;Berry DJ;Maradit Kremers H;Crowson CS
通讯作者：
Crowson CS