NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01) Clinical Trials Not Allowed

NARMS 加强零售食品样本抗生素耐药性监测的合作协议计划 (U01) 不允许进行临床试验

• 批准号: 10478026
• 负责人: Samir Hanna
• 金额: $ 18.7万
• 依托单位: TENNESSEE STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478026
• 关键词: NARMS; Cooperative; Agreement; Program; Strengthen

Project Summary/Abstract The Tennessee Department of Health (TDH) is a long-term participant and leader in the National Antimicrobial Resistance Monitoring System Retail Food Surveillance (RFS) program. TDH feels that the expansion of the retail food arm of NARMS is critical step in conducting surveillance for antimicrobial resistance (AR) in the food chain and for monitoring the impact of recent national initiatives including important regulatory changes in the use of antimicrobials in food animals. Use of antimicrobials in food animal production creates selective pressure that enables antimicrobial resistant bacteria to matriculate into the food supply and ultimately cause human infections. Of concern, antibiotic resistant infections are accompanied by more severe illnesses, more deaths, higher healthcare costs, and increased harm to society. We feel that surveillance is critical “data-for-action” to not only understand the sources of AR and multi-drug resistance (MDR) in the food supply chain but to combat this public health problem. Tennessee embraces the goal of the NARMS food surveillance program to improve the detection of and surveillance for AR among enteric bacteria in raw retail food commodities through this cooperative funding agreement (FOA # PAR-20-124, CFDA # 93.876). Tennessee will participate fully in all project components including purchase of approved meats and seafood, testing by NARMS protocols, shipment of isolates and meta data, and continued activity in the NARMS working groups. Additionally, Tennessee anticipates participating in any future pilot activity or expansion to other commodities. Tennessee capacity for testing food has translated to increased ability to assess isolates and their link to human clusters, as well as more proficiency in testing food during outbreaks and quickly characterizing the AR properties to inform the public heath investigation. Tennessee will participate fully in all NARMS RFS activities and follow the accepted protocols during the 5 year period. Our strategy include: 1. Maintain sampling and reporting with a continuous quality improvement paradigm in RFS. 2. Foster partnership among Tennessee, federal, state, local, and external partners. 3. Enhance outbreak investigation response and reporting. 4. Sustain and enhance NARMS laboratory diagnostic capacity. 6.Improve laboratory coordination, outreach, and information flow. 7. Maintain and exchange integrated surveillance information system. Tennessee’s expectations and outcomes, strategies and activities, and collaborative activities will continue throughout the 5 year period with continued funding. We hope our response to this FOA will be favorably considered.

项目概要/摘要 田纳西州卫生部 (TDH) 是该领域的长期参与者和领导者 国家抗菌素耐药性监测系统零售食品监测 (RFS) 程序。 TDH 认为 NARMS 零售食品部门的扩张是实现这一目标的关键一步 对食物链中的抗菌素耐药性（AR）进行监测 监测近期国家举措的影响，包括重要的监管 食用动物中抗菌药物使用的变化。抗菌剂在食品中的使用 动物生产产生选择性压力，导致抗菌药物产生耐药性 细菌进入食品供应并最终导致人类感染。的 令人担忧的是，抗生素耐药性感染伴随着更严重的疾病， 死亡、更高的医疗费用以及对社会的更大危害。我们觉得 监视对于“采取行动的数据”至关重要，不仅可以了解 AR 的来源， 食品供应链中的多重耐药性（MDR），但要对抗这种公共卫生 问题。田纳西州拥护 NARMS 食品监测计划的目标 改进生鲜零售中肠道细菌 AR 的检测和监测 通过该合作资助协议（FOA # PAR-20-124， CFDA#93.876）。田纳西州将全面参与所有项目组成部分，包括 购买经批准的肉类和海鲜、按照 NARMS 协议进行测试、运输 分离物和元数据，以及 NARMS 工作组的持续活动。 此外，田纳西州预计参与任何未来的试点活动或扩展 到其他商品。田纳西州食品检测能力已提高 评估分离株及其与人类群体的联系的能力，以及更熟练地 在疫情爆发期间测试食品并快速表征 AR 特性以告知 公共卫生调查。田纳西州将全面参与所有 NARMS RFS 活动 并在 5 年内遵循公认的协议。我们的策略包括： 1. 通过持续的质量改进范例来维护采样和报告 RFS。 2. 促进田纳西州、联邦、州、地方和外部之间的伙伴关系 合作伙伴。 3.加强疫情调查响应和报告。 4. 维持和 提高NARMS实验室诊断能力。 6.改善实验室协调， 外展和信息流通。 7. 维护和交换综合监控 信息系统。田纳西州的期望和成果、战略和活动， 合作活动将在整个 5 年期间持续进行 资金。我们希望我们对此 FOA 的回应能够得到积极考虑。