NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01) Clinical Trials Not Allowed

NARMS 加强零售食品样本抗生素耐药性监测的合作协议计划 (U01) 不允许进行临床试验

• 批准号: 10478026
• 负责人: Samir Hanna
• 金额: $ 18.7万
• 依托单位: TENNESSEE STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478026
• 关键词: NARMS; Cooperative; Agreement; Program; Strengthen

Project Summary/Abstract The Tennessee Department of Health (TDH) is a long-term participant and leader in the National Antimicrobial Resistance Monitoring System Retail Food Surveillance (RFS) program. TDH feels that the expansion of the retail food arm of NARMS is critical step in conducting surveillance for antimicrobial resistance (AR) in the food chain and for monitoring the impact of recent national initiatives including important regulatory changes in the use of antimicrobials in food animals. Use of antimicrobials in food animal production creates selective pressure that enables antimicrobial resistant bacteria to matriculate into the food supply and ultimately cause human infections. Of concern, antibiotic resistant infections are accompanied by more severe illnesses, more deaths, higher healthcare costs, and increased harm to society. We feel that surveillance is critical “data-for-action” to not only understand the sources of AR and multi-drug resistance (MDR) in the food supply chain but to combat this public health problem. Tennessee embraces the goal of the NARMS food surveillance program to improve the detection of and surveillance for AR among enteric bacteria in raw retail food commodities through this cooperative funding agreement (FOA # PAR-20-124, CFDA # 93.876). Tennessee will participate fully in all project components including purchase of approved meats and seafood, testing by NARMS protocols, shipment of isolates and meta data, and continued activity in the NARMS working groups. Additionally, Tennessee anticipates participating in any future pilot activity or expansion to other commodities. Tennessee capacity for testing food has translated to increased ability to assess isolates and their link to human clusters, as well as more proficiency in testing food during outbreaks and quickly characterizing the AR properties to inform the public heath investigation. Tennessee will participate fully in all NARMS RFS activities and follow the accepted protocols during the 5 year period. Our strategy include: 1. Maintain sampling and reporting with a continuous quality improvement paradigm in RFS. 2. Foster partnership among Tennessee, federal, state, local, and external partners. 3. Enhance outbreak investigation response and reporting. 4. Sustain and enhance NARMS laboratory diagnostic capacity. 6.Improve laboratory coordination, outreach, and information flow. 7. Maintain and exchange integrated surveillance information system. Tennessee’s expectations and outcomes, strategies and activities, and collaborative activities will continue throughout the 5 year period with continued funding. We hope our response to this FOA will be favorably considered.

项目总结/摘要 田纳西州卫生部（TDH）是一个长期的参与者和领导者， 国家抗菌素耐药性监测系统零售食品监测（RFS） 程序. TDH认为，NARMS零售食品部门的扩张是 监测食物链中的抗菌素耐药性， 监测最近的国家举措的影响，包括重要的监管 食用动物抗菌药物使用的变化。在食物中使用抗菌剂 动物生产创造了选择性压力， 细菌进入食物供应并最终导致人类感染。的 值得关注的是，抗生素耐药性感染伴随着更严重的疾病， 死亡，更高的医疗成本和对社会的危害增加。我们觉得 监测是至关重要的“数据行动”，不仅要了解AR的来源， 食品供应链中的多药耐药性（MDR），但要打击这种公共卫生 问题.田纳西州接受NARMS食品监督计划的目标， 加强对生鲜食品零售中肠道菌群中AR的检测和监测 通过这一合作供资协议（FOA # PAR-20-124， CFDA # 93.876）。田纳西州将全面参与项目的所有组成部分，包括 购买批准的肉类和海鲜，通过NARMS协议进行测试， 分离株和Meta数据，并继续在NARMS工作组的活动。 此外，田纳西州预计将参与任何未来的试点活动或扩大 其他商品。田纳西州测试食品的能力已经转化为增加 能够评估分离株及其与人类集群的联系，以及更熟练地 在疫情爆发期间检测食物，并快速描述AR特性， 公共卫生调查田纳西州将充分参与所有NARMS RFS活动 并在5年内遵守公认的协议。我们的策略包括：1. 以持续质量改进的范例维护采样和报告， RFS。2.促进田纳西州、联邦、州、地方和外部之间的伙伴关系 伙伴3.加强疫情调查反应和报告。4.维持和 提高NARMS实验室诊断能力。6.加强实验室协调， 外展和信息流。7.维护和交换综合监视 信息系统田纳西州的期望和成果，战略和活动， 合作活动将在整个5年期间继续进行， 经费我们希望我们对本FOA的答复能得到积极的考虑。