NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01) Clinical Trials Not Allowed

NARMS 加强零售食品样本抗生素耐药性监测的合作协议计划 (U01) 不允许进行临床试验

• 批准号: 10478026
• 负责人: Samir Hanna
• 金额: $ 18.7万
• 依托单位: TENNESSEE STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10478026
• 关键词: NARMS; Cooperative; Agreement; Program; Strengthen

Project Summary/Abstract The Tennessee Department of Health (TDH) is a long-term participant and leader in the National Antimicrobial Resistance Monitoring System Retail Food Surveillance (RFS) program. TDH feels that the expansion of the retail food arm of NARMS is critical step in conducting surveillance for antimicrobial resistance (AR) in the food chain and for monitoring the impact of recent national initiatives including important regulatory changes in the use of antimicrobials in food animals. Use of antimicrobials in food animal production creates selective pressure that enables antimicrobial resistant bacteria to matriculate into the food supply and ultimately cause human infections. Of concern, antibiotic resistant infections are accompanied by more severe illnesses, more deaths, higher healthcare costs, and increased harm to society. We feel that surveillance is critical “data-for-action” to not only understand the sources of AR and multi-drug resistance (MDR) in the food supply chain but to combat this public health problem. Tennessee embraces the goal of the NARMS food surveillance program to improve the detection of and surveillance for AR among enteric bacteria in raw retail food commodities through this cooperative funding agreement (FOA # PAR-20-124, CFDA # 93.876). Tennessee will participate fully in all project components including purchase of approved meats and seafood, testing by NARMS protocols, shipment of isolates and meta data, and continued activity in the NARMS working groups. Additionally, Tennessee anticipates participating in any future pilot activity or expansion to other commodities. Tennessee capacity for testing food has translated to increased ability to assess isolates and their link to human clusters, as well as more proficiency in testing food during outbreaks and quickly characterizing the AR properties to inform the public heath investigation. Tennessee will participate fully in all NARMS RFS activities and follow the accepted protocols during the 5 year period. Our strategy include: 1. Maintain sampling and reporting with a continuous quality improvement paradigm in RFS. 2. Foster partnership among Tennessee, federal, state, local, and external partners. 3. Enhance outbreak investigation response and reporting. 4. Sustain and enhance NARMS laboratory diagnostic capacity. 6.Improve laboratory coordination, outreach, and information flow. 7. Maintain and exchange integrated surveillance information system. Tennessee’s expectations and outcomes, strategies and activities, and collaborative activities will continue throughout the 5 year period with continued funding. We hope our response to this FOA will be favorably considered.

项目摘要/摘要 田纳西州卫生部是该项目的长期参与者和领导者。 国家抗菌素耐药性监测系统零售食品监测(RFS) 程序。TDH认为，NARMS零售食品部门的扩张是 监测食物链中的抗菌素耐药性(AR)和 监测最近的国家倡议的影响，包括重要的监管措施 食用动物中使用抗菌剂的变化。食品中抗菌剂的使用 动物生产造成选择性压力，使抗菌素产生抗药性 细菌进入食物供应，最终导致人类感染。的 令人担忧的是，抗生素耐药性感染伴随着更严重的疾病，更多 死亡、更高的医疗成本和更大的社会危害性。我们觉得 监测是至关重要的“数据行动”，不仅是为了了解AR和 食品供应链中的多药耐药(MDR)，但要与这种公共卫生作斗争 有问题。田纳西州接受了NARMS食品监测计划的目标 加强生鲜零售环节肠道细菌AR的检测和监测 通过这项合作筹资协议(FOA#PAR-20-124， 中国食品药品监督管理局93.876号)。田纳西州将全面参与所有项目组成部分，包括 购买经批准的肉类和海鲜，通过NARMS协议进行检测，发货 隔离和元数据，以及NARMS工作组的持续活动。 此外，田纳西州预计将参与任何未来的试点活动或扩张 到其他大宗商品。田纳西州检测食品的能力已经转化为 能够评估分离株及其与人类集群的联系，以及更熟练地 在疫情爆发期间测试食品并快速表征AR特性，以告知 公共卫生调查。田纳西州将全面参与NARMS RFS的所有活动 并在5年内遵循公认的协议。我们的战略包括：1. 通过持续的质量改进范例维护抽样和报告 RFS。2.促进田纳西州、联邦、州、地方和外部之间的伙伴关系 合伙人。3.加强疫情调查应对和报告。4.持续和 增强NARMS实验室诊断能力。6.加强实验室协调， 外展和信息流。7.维护和交换综合监视 信息系统。田纳西州的预期和结果、战略和活动， 协作活动将在整个5年内继续进行，并将继续 资金问题。我们希望我们对这一FOA的回应将得到有利的考虑。