NARMS Cooperative Agreement Program to Strengthen Antibiotic Resistance Surveillance in Retail Food Specimens (U01) Clinical Trials Not Allowed

NARMS 加强零售食品样本抗生素耐药性监测的合作协议计划 (U01) 不允许进行临床试验

• 批准号: 10170519
• 负责人: JOHN ROBERT DUNN
• 金额: $ 17万
• 依托单位: TENNESSEE STATE DEPARTMENT OF HEALTH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10170519
• 关键词: NARMS; Cooperative; Agreement; Program; Strengthen

Project Summary/Abstract The Tennessee Department of Health (TDH) is a long-term participant and leader in the National Antimicrobial Resistance Monitoring System Retail Food Surveillance (RFS) program. TDH feels that the expansion of the retail food arm of NARMS is critical step in conducting surveillance for antimicrobial resistance (AR) in the food chain and for monitoring the impact of recent national initiatives including important regulatory changes in the use of antimicrobials in food animals. Use of antimicrobials in food animal production creates selective pressure that enables antimicrobial resistant bacteria to matriculate into the food supply and ultimately cause human infections. Of concern, antibiotic resistant infections are accompanied by more severe illnesses, more deaths, higher healthcare costs, and increased harm to society. We feel that surveillance is critical “data-for-action” to not only understand the sources of AR and multi-drug resistance (MDR) in the food supply chain but to combat this public health problem. Tennessee embraces the goal of the NARMS food surveillance program to improve the detection of and surveillance for AR among enteric bacteria in raw retail food commodities through this cooperative funding agreement (FOA # PAR-20-124, CFDA # 93.876). Tennessee will participate fully in all project components including purchase of approved meats and seafood, testing by NARMS protocols, shipment of isolates and meta data, and continued activity in the NARMS working groups. Additionally, Tennessee anticipates participating in any future pilot activity or expansion to other commodities. Tennessee capacity for testing food has translated to increased ability to assess isolates and their link to human clusters, as well as more proficiency in testing food during outbreaks and quickly characterizing the AR properties to inform the public heath investigation. Tennessee will participate fully in all NARMS RFS activities and follow the accepted protocols during the 5 year period. Our strategy include: 1. Maintain sampling and reporting with a continuous quality improvement paradigm in RFS. 2. Foster partnership among Tennessee, federal, state, local, and external partners. 3. Enhance outbreak investigation response and reporting. 4. Sustain and enhance NARMS laboratory diagnostic capacity. 6.Improve laboratory coordination, outreach, and information flow. 7. Maintain and exchange integrated surveillance information system. Tennessee’s expectations and outcomes, strategies and activities, and collaborative activities will continue throughout the 5 year period with continued funding. We hope our response to this FOA will be favorably considered.

项目摘要/摘要 田纳西州卫生部（TDH）是长期参与者和领导者 国家抗菌素抵抗监测系统零售食品监视（RFS） 程序。 TDH认为NARMS零售食品部门的扩展是至关重要的一步 在食物链中进行抗菌耐药性（AR）的监视 监视最近的国家倡议的影响，包括重要的监管 食用动物中抗菌素使用的使用变化。在食物中使用抗菌素 动物生产产生选择性压力，使抗菌素抗性 细菌以基质为食品供应并最终引起人类感染。的 担心，抗生素耐药性感染是通过更严重的疾病来完成的，更多 死亡，更高的医疗保健成本以及对社会的伤害增加。我们感到 监视是至关重要的“数据行动”，不仅了解AR的来源和 食品供应链中的多药抵抗（MDR），但要与这种公共卫生作斗争 问题。田纳西州涵盖了NARMS食品监视计划的目标 改善原始零售中肠细菌中AR的检测和监视 食品商品通过这项合作资金协议（FOA＃PAR-20-124， CFDA＃93.876）。田纳西州将充分参与所有项目组件 购买批准的肉类和海鲜，NARMS协议测试，运输 分离和元数据，以及NARMS工作组的持续活动。 此外，田纳西州预计将参加任何未来的飞行员活动或扩展 到其他商品。田纳西州测试食品的能力已转化为增加 能够评估隔离及其与人类群集的联系的能力，以及更多的熟练程度 在暴发期间测试食物，并迅速表征AR的特性以告知 公共荒地调查。田纳西州将充分参加所有NARMS RFS活动 并遵循5年期间的公认协议。我们的策略包括：1。 通过持续的质量改进范式维护采样和报告 RFS。 2。田纳西州，联邦，州，地方和外部的促进伙伴关系 合作伙伴。 3。增强爆发调查的反应和报告。 4。维持和 增强NARMS实验室诊断能力。 6. Indrover实验室协调， 外展和信息流。 7。维护和交换综合监视 信息系统。田纳西州的期望和成果，战略和活动， 并将在整个5年期间继续进行协作活动 资金。我们希望我们对这一FOA的回应将得到好评。