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Midlife cognitive aging in Hispanic/Latinos: Predictors and mechanisms of decline

西班牙裔/拉丁裔中年认知衰老：衰退的预测因素和机制

基本信息

批准号：
10478858
负责人：
RICHARD W ROBINS
金额：
$ 71.63万
依托单位：
FLORIDA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10478858
关键词：
Acculturation Adherence Adult Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Behavioral Biological Markers Brain California Caregivers Clinical Cognition Cognitive Cognitive aging Communities Community Healthcare Complex Data Collection Dementia Diagnosis Discrimination Economics Education Elderly Ethnic group Face Family Financial Hardship Funding Genetic Predisposition to Disease Goals Growth Health Healthcare Systems Hispanic Hispanic Populations Impaired cognition Individual Inflammation Intervention Knowledge Latino Latino Population Longevity Longitudinal Studies Maintenance Measures Mediating Mexican Neurotic Disorders Not Hispanic or Latino Outcome Participant Pathway interactions Patients Pattern Performance Personality Physical activity Physiological Plant Roots Population Population Process Prevalence Prevention Process Research Risk Risk Factors Sampling Smoking Social Interaction Social support Stress Testing Time United States Work cognitive function cognitive testing cost shifting cultural values dementia risk depressive symptoms discounting disorder risk disparity reduction economic cost ethnic difference experience health disparity higher education loved ones middle age mild cognitive impairment modifiable risk neuropathology physical inactivity predictive test pressure prevent preventive intervention processing speed programs protective factors psychosocial resilience social social determinants social disparities social integration socioeconomics trend

项目摘要

PROJECT SUMMARY Individuals from Hispanic/Latino backgrounds have a 50% increased risk of Alzheimer's disease (AD) compared to non-Hispanic white individuals. With the changing demographic trends in the United States, the prevalence of AD in the Hispanic/Latino population is expected to increase nine fold over the next 50 years. In addition to the patient, the burden of AD takes a significant toll on the families of loved ones with dementia, their communities, and the healthcare system. The difference in prevalence of AD is rooted in social disparities rather than differences in genetic vulnerability between Hispanic/Latino and white populations. It is critical to identify the specific social determinants in Hispanic/Latino populations that can be leveraged to develop culturally informed interventions that aim to maintain cognitive health and slow or prevent the progression toward mild cognitive impairment and clinical dementia. Midlife is a particularly important, yet understudied, period of the lifespan for cognitive aging. Prevention and intervention efforts are likely to be more effective if started before significant neuropathology accumulates in the brain. The objective of this proposal is to identify midlife factors and associated processes that contribute to health disparities in cognitive decline and risk of dementia. We will leverage an existing longitudinal study of midlife adults – the California Families Project – to couple more than 10 years of repeated assessments across middle adulthood with new data collection on the risk/protective factors and cognitive outcomes. This project will test socioeconomic (e.g., education, financial hardship), personality (e.g., neuroticism, conscientiousness), social (e.g., discrimination, social support), and acculturation (e.g., cultural values, acculturative stress) risk/protective factors for cognitive functioning in midlife Hispanic/Latino adults and the behavioral (e.g., physical inactivity, smoking), psychosocial (e.g., depressive symptoms, delay discounting), and physiological (e.g., inflammation, cellular biomarkers) mechanisms that explain these associations. This work will lead to new knowledge on midlife predictors of cognition and risk of AD, identify social determinants and pathways that create and sustain health disparities for Hispanic/Latino populations, and point to new prevention and intervention targets for promoting healthy cognitive aging in midlife and beyond.

项目总结西班牙裔/拉丁裔背景的人患阿尔茨海默病(AD)的风险增加50% 与非西班牙裔白人相比。随着美国不断变化的人口趋势，西班牙裔/拉丁裔人口中的阿尔茨海默病患病率预计将在未来50年增加9倍。在……里面除了患者，阿尔茨海默病的负担还会给痴呆症亲人的家庭带来重大损失，他们的社区和医疗保健系统。阿尔茨海默病患病率的差异根源于社会差异而不是西班牙裔/拉丁裔和白人之间的遗传脆弱性差异。这是至关重要的确定拉美裔/拉美裔人口中可以利用的特定社会决定因素旨在保持认知健康并减缓或防止进展的文化知情干预导致轻度认知障碍和临床痴呆症。中年是一种特别重要但尚未得到充分研究的认知老化的生命周期。如果采取以下措施，预防和干预工作可能会更加有效在重大神经病变在大脑中积累之前就开始了。这项提案的目标是确定中年因素和相关过程导致认知能力下降和高血压风险方面的健康差异痴呆症。我们将利用现有的对中年成年人的纵向研究-加州家庭项目-来将超过10年的中年重复评估与新的数据收集结合在一起风险/保护因素和认知结果。该项目将测试社会经济(例如，教育、金融困难)、个性(如神经质、责任心)、社会(如歧视、社会支持)以及文化适应(例如，文化价值观、文化适应压力)中年认知功能的风险/保护因素西班牙裔/拉丁裔成年人与行为(例如，缺乏运动、吸烟)、心理社会(例如，抑郁) 症状、延迟折扣)和生理(例如，炎症、细胞生物标志物)机制解释这些联系。这项工作将导致对中年认知和风险预测因素的新认识广告，确定造成和维持拉美裔/拉丁裔健康差距的社会决定因素和途径并指出了促进健康认知老龄化的新的预防和干预目标中年及以后。