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Core 2: Biostatistics and Bioinformatics

核心2：生物统计学和生物信息学

基本信息

批准号：
10480087
负责人：
JEFFREY S MORRIS
金额：
$ 25.15万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-25 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10480087
关键词：
Address Basic Science Bioinformatics Biometry Clinical Research Clinical Sciences Conduct Clinical Trials Data Data Analyses Data Analytics Data Set Development Ensure Fibrosis Genomics Goals Laboratory Research Lateral Logistics Malignant neoplasm of liver Methodology Methods Molecular Morbidity - disease rate Paper Pathway interactions Primary carcinoma of the liver cells Publications Publishing Reporting Reproducibility Research Research Design Research Personnel Resources Statistical Data Interpretation Techniques Translational Research University of Texas M D Anderson Cancer Center Validation Work analytical tool archive data archived data base biomarker signature career computerized data processing data acquisition data handling data management design experience experimental study innovation member metabolomics models and simulation mortality novel novel marker preclinical study programs statistical service success

项目摘要

Core 2: Biostatistics and Bioinformatics - SUMMARY/ ABSTRACT The primary goal of the University of Texas MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma (HCC) is to facilitate innovative translational research through the elucidation of underlying molecular mechanisms, characterizing novel biomarkers and functional pathways, and exploiting novel targets for treatment. This is a collaborative effort that will accomplish these aims by integrating laboratory and translational research. The Biostatistics and Bioinformatics Core will serve multiple needs for the planning and conduct of the SPORE's research. Based on a strong track record for providing biostatistical and computational support for translational research, Core 2 will be a comprehensive, multi-lateral resource for designing clinical and basic science experiments, performing statistical analyses, developing innovative statistical methodology, and publishing the research results generated from this HCC SPORE. Core 2 will provide guidance in the design and conduct of clinical trials and other experiments arising from the ongoing research of the SPORE, including SPORE projects, Developmental and Career Enhancement projects, and other cores. Core 2 will also provide biostatistical and bioinformatic modeling, simulation techniques and data analyses needed by the Projects and other Cores to achieve their Specific Aims. Core 2 will generate statistical reports for all projects, will assist project investigators to publish scientific results and will develop innovative statistical and bioinformatics methods pertinent to translational HCC studies including new unsupervised approaches to biomarker signature construction.

核心2：生物统计学和生物信息学-摘要/摘要