CORE D: BIC Core

核心 D：BIC 核心

• 批准号: 10482398
• 负责人: DIETMAR CORDES
• 金额: $ 12.26万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10482398
• 关键词: Alzheimer' s Disease; Amyloid; Amyloid deposition; Award; Brain; Brain imaging; Centers of Research Excellence; Classification; Clinical; Clinical Research; Cognitive; Collaborations; Communities; Computer software; Data; Data Analyses; Data Analytics; Deposition; Development; Diagnosis; Diagnosis Clinical Trials; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Echo-Planar Imaging; Encephalitis; Fiber; Foundations; Functional Magnetic Resonance Imaging; Funding; Future; Goals; Human; Image; Image Analysis; Infrastructure; Knowledge; Magnetic Resonance Imaging; Measurement; Metabolism; Methods; Modality; Motion; Multivariate Analysis; Nerve Degeneration; Network-based; Neurodegenerative Disorders; Neurosciences; Nevada; Noise; Parkinson Disease; Patients; Pattern; Phase; Pilot Projects; Positron-Emission Tomography; Public Health; Quality Control; Research; Research Personnel; Research Support; Research Training; Rest; Role; Sampling; Services; Signal Transduction; Slice; System; Techniques; Technology; Testing; Time; Training; Translational Research; Universities; Water; analytical method; artificial neural network; base; career; cerebral atrophy; cohort; convolutional neural network; data fusion; data management; data sharing; deep neural network; denoising; imaging biomarker; imaging facilities; imaging modality; improved; interest; machine learning method; mild cognitive impairment; multimodality; neuroimaging; novel; novel imaging technique; novel therapeutics; statistics; success; tau Proteins; therapy development; tool; training opportunity; translational neuroscience; user friendly software; white matter

SUMMARY/ABSTRACT Brain Imaging Core This Center for Neurodegeneration and Translational Neuroscience (CNTN) COBRE Phase 2 application seeks the continuation of success achieved with the COBRE Phase 1 funding and includes a request to establish a Brain Imaging Core (BIC). The primary goals of the BIC are to expand and improve imaging and analytic data analyses methods, which will increase the success of the Phase 2 projects, generate new pilot projects, and establish collaborations with researchers from University of Nevada-Las Vegas (UNLV) and other Institutional Development Award (IDeA) state communities with interests in neuroimaging. Successful interaction of the BIC with the other Cores (Data Management and Statistic Core [DMSC], Clinical and Translational Neuroscience Core [CTNC]) and Phase 2 Junior Investigators (JIs) provides opportunity for advancement to independent research careers, build neuroscience infrastructure in Nevada, and advances the understanding of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Expert imaging and analytic capability is essential for supporting research and training and provides a foundation for transition of the BIC to a self-sustaining core. The major goals of the BIC are to provide support for JIs in neuroimaging research and to further characterize patients and cognitively normal controls using imaging and analytic data analyses. Furthermore, the BIC will develop tutorials for training on imaging and data analysis methods and will advance novel methods to better characterize patients with neurodegenerative disorders resulting in improved assessment, diagnosis, classification, and prediction accuracies, as well as tools for translational discovery. Imaging and data analysis approaches will be strengthened for all COBRE projects and the availability of analytical methods and training will provide significant support to JIs and other researchers throughout the COBRE system. Robust interactions between the brain imaging group that will comprise the BIC and collaborators in Phase 1 supports the creation of this new core in the CNTN.

摘要/摘要 脑成像核心 这个神经变性和转化神经科学中心(CNTN)Cobre第二阶段申请 继续利用科布雷第一阶段资金取得的成功，并包括要求建立一个 脑成像核心(BIC)。BIC的主要目标是扩展和改进成像和分析数据 分析方法，这将增加第二阶段项目的成功，产生新的试点项目，以及 与内华达大学拉斯维加斯分校(UNLV)和其他机构的研究人员建立合作关系 发展奖(IDEA)表彰对神经成像感兴趣的社区。BIC的成功互动 与其他核心(数据管理和统计核心[DMSc]、临床和翻译神经科学 核心[cTNC])和第二阶段初级调查员(JIS)为独立调查提供了机会 研究事业，在内华达州建立神经科学基础设施，并促进对阿尔茨海默氏症的理解 疾病(AD)和帕金森氏病(PD)。专家成像和分析能力是支持 研究和培训，并为BIC向自给自足的核心过渡奠定了基础。少校 BIC的目标是在神经成像研究方面为JIS提供支持，并进一步确定患者和 使用成像和分析数据分析的认知正常对照。此外，BIC将开发教程 用于影像和数据分析方法的培训，并将改进新方法，以更好地表征患者 神经退行性疾病可改善评估、诊断、分类和预测 准确性，以及翻译发现的工具。成像和数据分析方法将是 所有COBRE项目都得到了加强，分析方法和培训的可用性将提供重要的 在整个Cobre系统中为JIS和其他研究人员提供支持。大脑之间强健的相互作用 将由第一阶段的BIC和协作者组成的映像组支持在 CNTN。