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CORE D: BIC Core

核心 D：BIC 核心

基本信息

批准号：
10271796
负责人：
DIETMAR CORDES
金额：
$ 12.26万
依托单位：
CLEVELAND CLINIC FOUNDATION
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10271796
关键词：
Alzheimer&apos s Disease Amyloid Amyloid deposition Award Brain Brain imaging Centers of Research Excellence Classification Clinical Clinical Research Cognitive Collaborations Communities Computer software Data Data Analyses Data Analytics Deposition Development Diagnosis Diagnosis Clinical Trials Diffusion Magnetic Resonance Imaging Disease Disease Progression Echo-Planar Imaging Encephalitis Fiber Foundations Functional Magnetic Resonance Imaging Funding Future Goals Human Image Image Analysis Infrastructure Knowledge Magnetic Resonance Imaging Measurement Metabolism Methods Modality Motion Multivariate Analysis Nerve Degeneration Network-based Neurodegenerative Disorders Neurosciences Nevada Noise Parkinson Disease Patients Pattern Phase Pilot Projects Positron-Emission Tomography Public Health Quality Control Research Research Personnel Research Support Research Training Rest Role Sampling Services Signal Transduction Slice Structure System Techniques Technology Testing Time Training Translational Research Universities Water analytical method artificial neural network base career cerebral atrophy cohort convolutional neural network data fusion data management data sharing deep neural network denoising imaging biomarker imaging facilities imaging modality improved interest machine learning method mild cognitive impairment multimodality neuroimaging novel novel imaging technique novel therapeutics statistics success tau Proteins therapy development tool training opportunity translational neuroscience user friendly software white matter

项目摘要

SUMMARY/ABSTRACT Brain Imaging Core This Center for Neurodegeneration and Translational Neuroscience (CNTN) COBRE Phase 2 application seeks the continuation of success achieved with the COBRE Phase 1 funding and includes a request to establish a Brain Imaging Core (BIC). The primary goals of the BIC are to expand and improve imaging and analytic data analyses methods, which will increase the success of the Phase 2 projects, generate new pilot projects, and establish collaborations with researchers from University of Nevada-Las Vegas (UNLV) and other Institutional Development Award (IDeA) state communities with interests in neuroimaging. Successful interaction of the BIC with the other Cores (Data Management and Statistic Core [DMSC], Clinical and Translational Neuroscience Core [CTNC]) and Phase 2 Junior Investigators (JIs) provides opportunity for advancement to independent research careers, build neuroscience infrastructure in Nevada, and advances the understanding of Alzheimer’s disease (AD) and Parkinson’s disease (PD). Expert imaging and analytic capability is essential for supporting research and training and provides a foundation for transition of the BIC to a self-sustaining core. The major goals of the BIC are to provide support for JIs in neuroimaging research and to further characterize patients and cognitively normal controls using imaging and analytic data analyses. Furthermore, the BIC will develop tutorials for training on imaging and data analysis methods and will advance novel methods to better characterize patients with neurodegenerative disorders resulting in improved assessment, diagnosis, classification, and prediction accuracies, as well as tools for translational discovery. Imaging and data analysis approaches will be strengthened for all COBRE projects and the availability of analytical methods and training will provide significant support to JIs and other researchers throughout the COBRE system. Robust interactions between the brain imaging group that will comprise the BIC and collaborators in Phase 1 supports the creation of this new core in the CNTN.

摘要/文摘