PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients

我们已获得IRB批准，于2018年7月开始招募患者。我们于2018年11月20日开始成像。我们已经招募了总共38名接受过一次扫描（仅FDOPA扫描，n=1，仅DASB扫描，n=2）或两次扫描（FDOPA和DASB，n= 35）的受试者 多巴胺能系统成像： 1. A组：18例HIV感染者 2. 组B：11例无HIV感染且至少有1例合并症的受试者 3. C组：8例无HIV感染且无合并症的患者。 5-羟色胺转运蛋白成像（使用11 C-DASB的SERT）。 1. D组：HIV感染者16例。 2. E组：20例无HIV感染者。 更新：由于新冠疫情，我们有很长一段时间无法纳入受试者。我们于二零二零年底再次开始招募患者。此后，我们修改了我们的方案，以便能够从其他NIH内部方案中招募受试者，而不是从全体人员方案中招募受试者。这需要在这些受试者的方案中增加MRI和神经心理学测试。 数据分析：我们目前正在分析数据（操作者对该组不知情），即量化我们所有受试者脑中FDOPA和DASB的摄取。我们希望在2022年初至年中完成招聘并进行最终分析。

We have received IRB approval to start recruiting patients in July 2018. We started imaging on 11/20/2018. We have already recruited a total of 38 subjects who have undergone one scan (Only FDOPA scan, n=1, only DASB scan, n=2) or two scans (FDOPA and DASB, n= 35) Imaging the dopaminergic system: 1. Group A: 18 patients with HIV infection 2. Group B: 11 subjects without HIV infection with at least one co-morbidity 3. Group C: 8 patients without HIV infection without co-morbidities. Imaging of the Serotonin transporter (SERT using 11C-DASB). 1. Group D: 16 patients with HIV infection. 2. Group E: 20 patients without HIV infection. Updates: there was a long period of hiatus where we could not include subjects due to the covid epidemic. We started recruiting patients again in late 2020. We have since amended our protocol to be able to recruit subjects from other NIH intramural protocols other than the all hands protocol. This necessitated adding MRI and neuropsychological testing to the protocol for those subjects. Data analysis: we are currently analyzing the data (operator blinded for the group) namely quantifying FDOPA and DASB uptake in the brain of all our subjects. We are hoping to finalize recruitment and perform a final analysis in early to mid 2022.