PET imaging of presynaptic nigrostriatal dopaminergic function in optimally treated HIV+ patients

我们已获得IRB批准，于2018年7月开始招募患者。我们于2018年11月20日开始成像。我们已经招募了总共24名接受过一次扫描（仅FDOPA扫描，n=1，仅DASB扫描，n=2）或两次扫描（FDOPA和DASB，n= 22）的受试者 多巴胺能系统成像： 1. A组：来自Avi Nath博士的All Hands筛查队列的10名HIV感染患者。 2. B组：6例来自Avi Nath博士的All Hands筛查队列的无HIV感染且至少有1例合并症的受试者 3. C组：8名来自Avi Nath博士的All Hands筛查队列的无HIV感染且无合并症的患者。 5-羟色胺转运蛋白成像（使用11 C-DASB的SERT）。他们也将从纳特博士的“全勤”方案中招募。 1. D组：来自Avi Nath博士的All Hands筛查队列的9名HIV感染患者。 2. E组：来自Avi Nath博士的All Hands筛查队列的15名无HIV感染的患者。 数据分析：我们目前正在分析数据（操作者对组不知情），即定量我们所有受试者脑中的FDOPA和DASB摄取。我们将在2020年底前进行中期分析。此时，我们将集中招募合并症的HIV阴性受试者，以使FDOPA研究的所有组和DASB研究的HIV阳性受试者的数量相等。

We have received IRB approval to start recruiting patients in July 2018. We started imaging on 11/20/2018. We have already recruited a total of 24 subjects who have undergone one scan (Only FDOPA scan, n=1, only DASB scan, n=2) or two scans (FDOPA and DASB, n= 22) Imaging the dopaminergic system: 1. Group A: 10 patients with HIV infection from Dr Avi Nath's All Hands screening cohort. 2. Group B: 6 subjects without HIV infection from Dr Avi Nath's All Hands screening cohort AND with at least one co-morbidity 3. Group C: 8 patients without HIV infection from Dr Avi Nath's All Hands screening cohort AND without co-morbidities. Imaging of the Serotonin transporter (SERT using 11C-DASB. they will also be recruited from Dr Nath's all hands protocol. 1. Group D: 9 patients with HIV infection from Dr Avi Nath's All Hands screening cohort. 2. Group E: 15 patients without HIV infection from Dr Avi Nath's All Hands screening cohort. Data analysis: we are currently analyzing the data (operator blinded for group) namely quantifying FDOPA and DASB uptake in the brain of all our subjects. We will proceed with an interim analysis before the end of 2020. We will concentrate on recruiting HIV negative subjects with co-morbidities at this point to have equal numbers in all groups for the FDOPA study and HIV positive subjects for the DASB study.