病毒感染的分子成像-猫眼课题宝

病毒感染的分子成像

批准号：

10920173

负责人：

Dima A Hammoud

金额：

$0.0万

依托单位：

CLINICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/10920173

关键词：

2019-nCoV ACE2 Acids Acute Lung Injury Address Affinity Aftercare Albumins Animal Model Animals Binding Binding Sites Biological Assay Blood Bone Marrow Brain COVID-19 Cells Characteristics Collaborations Development Diagnosis Diagnostic Disease Disease Progression Down-Regulation Drug Kinetics Ebola Ebola virus Endothelium Extravasation Functional disorder Genes Goals HIV HIV Envelope Protein gp120 HIV Infections Human Image Implant Infection K-18 conjugate Knockout Mice Label Lassa virus Ligands Lipopolysaccharides Lung Magnetic Resonance Imaging Manuscripts Marburgvirus Measurement Mediating Molecular Biology Molecular Target Mus Nature Nipah Virus Nude Mice Organ Pathology Peripheral Positron-Emission Tomography Process Proteins Publishing Pulmonary Pathology Radiolabeled Recombinants Role SARS-CoV-2 infection SARS-CoV-2 spike protein Severities Site Spleen Therapeutic Intervention Tissues Type II Epithelial Receptor Cell Viral Virus Virus Diseases Virus Replication Wild Type Mouse Writing X-Ray Computed Tomography alveolar epithelium aspirate cecal ligation puncture central nervous system injury experimental study imaging modality improved in vivo in vivo imaging lung injury microPET/CT molecular imaging mouse model nanobodies natural antibodies non-invasive imaging protective pathway receptor research facility response tumor

项目摘要

项目成果

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中文摘要

翻译

进度： HIV项目：我们正在优化我们的动物模型，将表达gp120的HEK293肿瘤移植到裸鼠体内，与野生型肿瘤进行比较。我们已经用18F验证和标记了多个针对GP120的纳米体，并开始了PET成像。初步结果令人鼓舞，我们目前正在优化特定部位的结合。结果尚待公布。埃博拉和其他高后果病毒感染：我们正在与综合研究机构合作，进行多项研究，评估尼帕、拉萨、马尔堡、新冠肺炎和埃博拉感染。 SARS-CoV-2项目：我们已经完成了实验，目前正在撰写稿件。

英文摘要

Progress: HIV project: We are in the stage of optimizing our animal model of Gp120 expressing HEK293 tumors implanted in nude mice in comparison to wild type tumors. We have validated and labeled multiple nanobodies against GP120 with 18F and started PET imaging. Early results are encouraging and we are currently optimizing site specific binding. Results are pending. Ebola and other high consequence viral infection: We are collaborating with the Integrated research facility on multiple studies evaluating Nipah, Lassa, Marburg, Covid-19 and Ebola infections. Sars-Cov-2 project: We have finished our experiments and are currently writing the manuscript.

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