Administrative Core

项目总结--行政核心 行政核心(管理核心)的总体目标是提供必要的组织基础设施 刺激研究并加快将发现转化为新的更好的治疗方法 胶质母细胞瘤(GBM)。管理核心将通过提供领导、财务 管理，以及旨在有效协调研究活动的行政结构 项目、共享资源核心、胶质母细胞瘤治疗网络和网络协调 中心(NCC)。此外，管理核心纳入了生物统计部分，并将监督所有统计 为所有项目和核心提供支持。具体地说，管理核心将：1)提供领导、组织支持、 监督U19调查员的数据管理和财务管理；2)促进 加强三个参与机构之间互动的三个项目(希望之城、华盛顿大学 阿拉巴马州伯明翰和翻译基因组研究所)，内部顾问委员会(IAB) 和其他GTN U19研究中心；3)促进与其他U19研究中心的合作，以资助和 监督试点项目；4)作为与NCC合作实施网络最佳实践和 政策；以及5)提供生物统计学专业知识，以支持基础科学、翻译和临床研究。 拟议的U19结构由三个参与机构组成，将由波特诺博士指导 (联系PI)和Badie(MPI)在希望之城。这个团队的成员都很熟悉，而且都有自己的足迹 在GBM研究项目和领导希望之城脑瘤计划方面的合作记录。穿过 为了实现特定的目标，管理核心将确保U19的有效运行，以最大限度地提高我们的 提高效率，节约资源，加快GBM新疗法的临床开发。

PROJECT SUMMARY – ADMINISTRATIVE CORE The overall goal of the Administrative Core (Admin Core) is to provide the organizational infrastructure necessary to stimulate research and to expedite the translation of discoveries into new and better treatments for glioblastoma (GBM). The Admin Core will facilitate these activities by providing leadership, financial management, and an administrative structure designed to efficiently coordinate the activities of the research projects, shared resources cores, the Glioblastoma Therapeutics Network (GTN), and the Network Coordination Center (NCC). In addition, the Admin Core incorporates a biostatistical component and will oversee all statistical support to all Projects and Cores. Specifically, the Admin Core will: 1) Provide leadership, organizational support, oversight of data management, and financial management for the U19 investigators; 2) Promote integration of the three projects to enhance interaction among the three participating institutions (City of Hope, University of Alabama at Birmingham and the Translational Genomics Research Institute), the internal advisory board (IAB) and other GTN U19 Research Centers; 3) Facilitate collaboration with other U19 Research Centers to fund and oversee pilot projects; 4) Serve as the liaison working with the NCC to implement network best practices and policies; and 5) Provide biostatistical expertise to support basic science, translational, and clinical research. The proposed U19 structure, consisting of three participating institutions, will be directed by Drs. Portnow (Contact PI) and Badie (MPI) at City of Hope. The members of this team are well acquainted and have a track record of collaborating on GBM research projects and leading the City of Hope Brain Tumor Program. Through performance of the Specific Aims, the Admin Core will ensure effective functioning of the U19 to maximize our efficiency, conserve resources, and expedite clinical development of novel therapies for GBM.