Administrative Core

项目摘要-行政核心 管理核心的总体目标是提供必要的组织基础设施 刺激研究，加快将发现转化为新的更好的治疗方法， 胶质母细胞瘤（GBM）。行政核心将通过提供领导、财务和技术支持， 管理，以及旨在有效协调研究活动的行政结构 项目，共享资源核心，胶质母细胞瘤治疗网络（GTN）和网络协调 中心（NCC）。此外，管理核心包含生物统计组件，并将监督所有统计 支持所有项目和核心。具体而言，管理核心将：1）提供领导，组织支持， 监督U19调查人员的数据管理和财务管理; 2）促进 这三个项目旨在加强三个参与机构（希望之城、香港大学、 伯明翰的亚拉巴马和翻译基因组学研究所），内部顾问委员会（IAB） 和其他GTN U19研究中心; 3）促进与其他U19研究中心合作， 监督试点项目; 4）担任与NCC合作的联络人，以实施网络最佳实践， 政策; 5）提供生物统计专业知识，以支持基础科学，转化和临床研究。 拟议的U19结构由三个参与机构组成，将由Portnow博士指导。 （联系PI）和Badie（MPI）在City of Hope。这个团队的成员都很熟悉，有一个轨道 在GBM研究项目上合作并领导希望之城脑肿瘤计划的记录。通过 为了实现具体目标，管理核心将确保U19的有效运作，以最大限度地提高我们的 有效，节约资源，并加快GBM新疗法的临床开发。

PROJECT SUMMARY – ADMINISTRATIVE CORE The overall goal of the Administrative Core (Admin Core) is to provide the organizational infrastructure necessary to stimulate research and to expedite the translation of discoveries into new and better treatments for glioblastoma (GBM). The Admin Core will facilitate these activities by providing leadership, financial management, and an administrative structure designed to efficiently coordinate the activities of the research projects, shared resources cores, the Glioblastoma Therapeutics Network (GTN), and the Network Coordination Center (NCC). In addition, the Admin Core incorporates a biostatistical component and will oversee all statistical support to all Projects and Cores. Specifically, the Admin Core will: 1) Provide leadership, organizational support, oversight of data management, and financial management for the U19 investigators; 2) Promote integration of the three projects to enhance interaction among the three participating institutions (City of Hope, University of Alabama at Birmingham and the Translational Genomics Research Institute), the internal advisory board (IAB) and other GTN U19 Research Centers; 3) Facilitate collaboration with other U19 Research Centers to fund and oversee pilot projects; 4) Serve as the liaison working with the NCC to implement network best practices and policies; and 5) Provide biostatistical expertise to support basic science, translational, and clinical research. The proposed U19 structure, consisting of three participating institutions, will be directed by Drs. Portnow (Contact PI) and Badie (MPI) at City of Hope. The members of this team are well acquainted and have a track record of collaborating on GBM research projects and leading the City of Hope Brain Tumor Program. Through performance of the Specific Aims, the Admin Core will ensure effective functioning of the U19 to maximize our efficiency, conserve resources, and expedite clinical development of novel therapies for GBM.