Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病和相关痴呆症转化研究培训 (TRIAD)

• 批准号: 10493734
• 负责人: Michael Paul Murphy
• 金额: $ 50.88万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493734
• 关键词: Alzheimer' s disease related dementia; Training; Translational Research

ABSTRACT Our T32 training program entitled “Training in Translational Research In Alzheimer’s and Related Dementias (TRIAD)” aims to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to advance effective treatments for Alzheimer’s disease and related dementias (ADRD). We will continue to support 4 predoctoral and 4 postdoctoral trainees who will receive rigorous training through a transdisciplinary and integrative mentoring program that spans the discovery continuum from molecular/ biochemical methods, preclinical translational approaches, and clinical research. The thematic focus is on major ADRD risk factors, including cerebrovascular dysfunction, neuroinflammation, brain injury, and genetic/lifestyle risks. The 23 faculty mentors include well-funded investigators with established and extensive collaborative relationships and successful track records in training. The faculty mentors encompass diverse yet complementary areas of expertise along the translational continuum from cell and molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, biomarkers, neuropathology, clinical trials, and longitudinal clinical studies. The majority (20) of these mentors are faculty in the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer’s Disease Research Center (ADRC). The two-year training plan will emphasize 1) experiential research and learning of core competencies required to become independent leaders in clinical/ translational research, 2) a tailored educational plan that emphasizes the translational continuum from basic science to clinical to community, and 3) multidisciplinary mentoring from highly committed program faculty. Each trainee will develop an individualized development plan to enable advancement to independent research and funding. Trainees will participate in a structured educational program that includes a dedicated AD101 course, training in the responsible conduct of research, Good Research Practice training, data science, and workshops and seminars. Trainees will gain career development experiences through the monthly trainee-organized team meeting, presentations at the annual Markesbery Symposium on Aging and Dementia, and grant writing workshops. Trainees will also have the opportunity to participate in an experiential learning externship, which can include an off-site training course, visiting a collaborator’s lab to develop additional research skills, or visiting another ADRC to observe/shadow/learn specific aspects based on the trainee’s research interests. Quantitative and qualitative metrics for evaluation of trainees, mentors, and the training program will assure a high-quality and effective training experience. Overall, this T32 program is uniquely positioned to fill a growing need for a diverse, translational research workforce with the cross-disciplinary team science skills required to conduct rigorous and cutting-edge basic, translational, and clinical research to develop and advance effective interventions for ADRD.

抽象的 我们的 T32 培训计划题为“阿尔茨海默病和相关痴呆症转化研究培训” （TRIAD）”旨在提供从实验室到临床的跨学科培训，以产生新的转化 推进阿尔茨海默病及相关疾病的有效治疗急需的劳动力 痴呆症（ADRD）。我们将继续资助4名博士前和4名博士后学员，他们将获得 通过跨越发现的跨学科和综合指导计划进行严格的培训 分子/生化方法、临床前转化方法和临床研究的连续体。 主题重点是 ADRD 的主要危险因素，包括脑血管功能障碍、神经炎症、 脑损伤和遗传/生活方式风险。 23 名导师包括资金雄厚的研究人员 建立了广泛的合作关系和成功的培训记录。师资队伍 导师涵盖细胞转化连续体中不同但互补的专业领域 和分子生物学、遗传学和数据科学，通过临床前模型系统、治疗 发育、神经影像、生物标志物、神经病理学、临​​床试验和纵向临床研究。这 这些导师中的大多数（20 名）是肯塔基大学桑德斯·布朗老龄化中心的教师，该中心 包括一个由 NIA 资助的长期阿尔茨海默病研究中心 (ADRC)。为期两年的培训 计划将强调 1) 体验式研究和学习所需的核心能力 临床/转化研究的独立领导者，2) 量身定制的教育计划，强调 从基础科学到临床再到社区的转化连续体，以及 3） 高度敬业的项目教师。每位学员都将制定个性化的发展计划，以实现 推进独立研究和资助。学员将参加结构化的教育 计划，包括专门的 AD101 课程、负责任的研究行为培训、良好 研究实践培训、数据科学以及讲习班和研讨会。学员将获得职业发展 通过实习生组织的每月团队会议、年度 Markesbery 会议上的演讲获得经验 老龄化和痴呆症研讨会以及拨款写作研讨会。学员还将有机会 参加体验式学习实习，其中包括场外培训课程、参观 合作者的实验室以培养额外的研究技能，或访问另一个 ADRC 进行观察/影子/学习 基于受训者的研究兴趣的具体方面。用于评估的定量和定性指标 学员、导师和培训计划将确保高质量和有效的培训体验。全面的， 该 T32 项目具有独特的定位，可以满足对多样化、转化性研究人员日益增长的需求 具有进行严谨和尖端基础所需的跨学科团队科学技能， 转化和临床研究，以开发和推进 ADRD 的有效干预措施。