Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

摘要 我们的T32培训项目名为“阿尔茨海默氏症及相关痴呆的翻译研究培训” (三合会)“旨在提供从板凳到床边的跨学科培训，以产生新的翻译 推进阿尔茨海默病及相关疾病的有效治疗所急需的劳动力 痴呆(ADRD)。我们将继续支持4名博士后和4名博士后实习生获得 通过跨学科的综合指导计划进行严格的培训 来自分子/生化方法、临床前转化方法和临床研究的连续体。 主题集中在主要的ADRD风险因素上，包括脑血管功能障碍、神经炎症、 脑损伤和遗传/生活方式风险。23名教员导师包括资金雄厚的调查人员 在培训方面建立了广泛的合作关系和成功的记录。教职员工 导师涵盖了CELL翻译连续体中不同但互补的专业知识领域 以及分子生物学、遗传学和数据科学，通过临床前模型系统，治疗 发展、神经成像、生物标记物、神经病理学、临床试验和纵向临床研究。这个 这些导师中的大多数(20人)是肯塔基大学桑德斯·布朗老龄中心的教职员工，该中心 包括一个长期由NIA资助的阿尔茨海默病研究中心(ADRC)。为期两年的培训 计划将强调1)体验式研究和对核心能力的学习 临床/转化性研究的独立领导者，2)量身定制的教育计划，强调 从基础科学到临床再到社区的转换连续体，以及3)来自 高度敬业的项目教员。每个学员将制定个性化的发展计划，以实现 向独立研究和资助迈进。学员将参加有组织的教育 该计划包括专门的AD101课程，负责的研究行为培训，很好 研究实践培训、数据科学以及研讨会和研讨会。学员将获得职业发展 通过每月实习生组织的团队会议和在年度Markesbury上的演讲获得经验 老龄化和痴呆症研讨会，以及赠款撰写工作坊。学员还将有机会 参加体验式学习，其中可以包括场外培训课程，参观 合作者的实验室，以发展额外的研究技能，或访问另一个ADRC观察/跟踪/学习 根据受训者的研究兴趣确定具体方面。用于评估的定量和定性指标 学员、导师和培训计划将确保高质量和有效的培训体验。总的来说， 这一T32计划具有独特的定位，可满足日益增长的多样化、翻译研究队伍的需求 具有进行严谨和尖端基础训练所需的跨学科团队科学技能， 翻译和临床研究，以开发和推进有效的ADRD干预措施。

ABSTRACT Our T32 training program entitled “Training in Translational Research In Alzheimer’s and Related Dementias (TRIAD)” aims to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to advance effective treatments for Alzheimer’s disease and related dementias (ADRD). We will continue to support 4 predoctoral and 4 postdoctoral trainees who will receive rigorous training through a transdisciplinary and integrative mentoring program that spans the discovery continuum from molecular/ biochemical methods, preclinical translational approaches, and clinical research. The thematic focus is on major ADRD risk factors, including cerebrovascular dysfunction, neuroinflammation, brain injury, and genetic/lifestyle risks. The 23 faculty mentors include well-funded investigators with established and extensive collaborative relationships and successful track records in training. The faculty mentors encompass diverse yet complementary areas of expertise along the translational continuum from cell and molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, biomarkers, neuropathology, clinical trials, and longitudinal clinical studies. The majority (20) of these mentors are faculty in the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer’s Disease Research Center (ADRC). The two-year training plan will emphasize 1) experiential research and learning of core competencies required to become independent leaders in clinical/ translational research, 2) a tailored educational plan that emphasizes the translational continuum from basic science to clinical to community, and 3) multidisciplinary mentoring from highly committed program faculty. Each trainee will develop an individualized development plan to enable advancement to independent research and funding. Trainees will participate in a structured educational program that includes a dedicated AD101 course, training in the responsible conduct of research, Good Research Practice training, data science, and workshops and seminars. Trainees will gain career development experiences through the monthly trainee-organized team meeting, presentations at the annual Markesbery Symposium on Aging and Dementia, and grant writing workshops. Trainees will also have the opportunity to participate in an experiential learning externship, which can include an off-site training course, visiting a collaborator’s lab to develop additional research skills, or visiting another ADRC to observe/shadow/learn specific aspects based on the trainee’s research interests. Quantitative and qualitative metrics for evaluation of trainees, mentors, and the training program will assure a high-quality and effective training experience. Overall, this T32 program is uniquely positioned to fill a growing need for a diverse, translational research workforce with the cross-disciplinary team science skills required to conduct rigorous and cutting-edge basic, translational, and clinical research to develop and advance effective interventions for ADRD.