Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病和相关痴呆症转化研究培训 (TRIAD)

• 批准号: 10493734
• 负责人: Michael Paul Murphy
• 金额: $ 50.88万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493734
• 关键词: Alzheimer' s disease related dementia; Training; Translational Research

ABSTRACT Our T32 training program entitled “Training in Translational Research In Alzheimer’s and Related Dementias (TRIAD)” aims to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to advance effective treatments for Alzheimer’s disease and related dementias (ADRD). We will continue to support 4 predoctoral and 4 postdoctoral trainees who will receive rigorous training through a transdisciplinary and integrative mentoring program that spans the discovery continuum from molecular/ biochemical methods, preclinical translational approaches, and clinical research. The thematic focus is on major ADRD risk factors, including cerebrovascular dysfunction, neuroinflammation, brain injury, and genetic/lifestyle risks. The 23 faculty mentors include well-funded investigators with established and extensive collaborative relationships and successful track records in training. The faculty mentors encompass diverse yet complementary areas of expertise along the translational continuum from cell and molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, biomarkers, neuropathology, clinical trials, and longitudinal clinical studies. The majority (20) of these mentors are faculty in the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer’s Disease Research Center (ADRC). The two-year training plan will emphasize 1) experiential research and learning of core competencies required to become independent leaders in clinical/ translational research, 2) a tailored educational plan that emphasizes the translational continuum from basic science to clinical to community, and 3) multidisciplinary mentoring from highly committed program faculty. Each trainee will develop an individualized development plan to enable advancement to independent research and funding. Trainees will participate in a structured educational program that includes a dedicated AD101 course, training in the responsible conduct of research, Good Research Practice training, data science, and workshops and seminars. Trainees will gain career development experiences through the monthly trainee-organized team meeting, presentations at the annual Markesbery Symposium on Aging and Dementia, and grant writing workshops. Trainees will also have the opportunity to participate in an experiential learning externship, which can include an off-site training course, visiting a collaborator’s lab to develop additional research skills, or visiting another ADRC to observe/shadow/learn specific aspects based on the trainee’s research interests. Quantitative and qualitative metrics for evaluation of trainees, mentors, and the training program will assure a high-quality and effective training experience. Overall, this T32 program is uniquely positioned to fill a growing need for a diverse, translational research workforce with the cross-disciplinary team science skills required to conduct rigorous and cutting-edge basic, translational, and clinical research to develop and advance effective interventions for ADRD.

摘要 我们的T32培训计划题为“阿尔茨海默氏症和相关痴呆症转化研究培训 （TRIAD）”旨在提供从板凳到床边的跨学科培训，以产生一个新的翻译 这是迫切需要的劳动力，以推进有效的治疗阿尔茨海默病和相关的 痴呆症（ADRD）。我们将继续支持4名博士前和4名博士后培训生，他们将获得 通过跨学科和综合性的指导计划进行严格的培训， 分子/生物化学方法、临床前转化方法和临床研究的连续体。 主题重点是ADRD的主要风险因素，包括脑血管功能障碍，神经炎症， 脑损伤和遗传/生活方式风险。23名教师导师包括资金充足的调查人员， 建立广泛的合作关系，并在培训方面取得成功。学院 导师包括沿着从cell到 和分子生物学，遗传学和数据科学，通过临床前模型系统， 开发、神经成像、生物标志物、神经病理学、临床试验和纵向临床研究。的 这些导师中的大多数（20）是肯塔基州桑德斯布朗大学老龄化中心的教师，该中心 包括一个长期由美国国家情报局资助的阿尔茨海默病研究中心（ADRC）。两年制培训 该计划将强调1）经验研究和核心能力的学习，成为 临床/转化研究的独立领导者，2）量身定制的教育计划，强调 从基础科学到临床到社区的转化连续体，以及3）多学科指导， 高度敬业的项目教师。每位学员将制定个性化的发展计划， 推动独立研究和资助。学员将参加一个结构化的教育 该计划包括一个专门的AD 101课程，在负责任的研究行为，良好的培训 研究实践培训，数据科学，讲习班和研讨会。学员将获得职业发展 通过每月由受训者组织的团队会议，在年度Markesbery会议上的演讲， 关于老龄化和痴呆症的研讨会，以及赠款写作讲习班。学员还将有机会 参加体验式学习实习，其中可以包括场外培训课程，参观 合作者的实验室发展额外的研究技能，或访问另一个ADRC观察/影子/学习 根据学员的研究兴趣确定具体方面。评估的定量和定性指标 学员、导师和培训计划将确保高质量和有效的培训体验。总的来说， 这个T32计划具有独特的定位，以满足日益增长的多样化，转化研究工作队伍的需求 与跨学科的团队科学所需的技能进行严格和尖端的基本， 转化和临床研究，以开发和推进ADRD的有效干预措施。