Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病及相关痴呆症转化研究培训 (TRIAD)

• 批准号: 9759743
• 负责人: Michael Paul Murphy
• 金额: $ 47.39万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9759743
• 关键词: Alzheimer' s disease related dementia; Training; Translational Research

7. PROJECT SUMMARY/ABSTRACT This is an application for a T32 training grant titled “Training in Translational Research in Alzheimer's Disease and Related Dementias (TRIAD)” to support 4 predoctoral and 4 postdoctoral fellows. The overall goal of the proposed program is to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to develop and advance effective treatments for Alzheimer's disease and related dementias. Trainees will receive rigorous and innovative translational research education and training through a 3-cluster multidisciplinary and integrative mentoring program that spans the discovery continuum from molecular/biochemical methods, preclinical translational approaches and clinical research. The thematic focus is on risk factors for Alzheimer's disease and related dementias; these risk factors include cerebrovascular disease, neuroinflammation, Down syndrome, and traumatic brain injury. The training program has 18 faculty mentors with established and extensive interactions and collaborations, and successful track records in training. The faculty mentors encompass diverse areas of expertise from cell & molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, neuropathology, clinical trials, and longitudinal clinical studies. The majority (13) of these mentors are housed within the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer's Disease Center. All faculty with primary appointments in a Center also have academic appointments in other basic science or clinical departments at the University of Kentucky. Predoctoral trainees will be recruited from our Integrated Biomedical Sciences graduate program and from the MD/PhD program in the College of Medicine, and postdoctoral trainees through targeted advertisement and recommendations from colleagues and other Alzheimer's Disease Centers. In addition to their individualized research program and career development plan, each group of trainees will participate in a series of educational experiences that include a dedicated AD101 course in Alzheimer's disease and related dementias, seminars describing research and clinic ethics, monthly research and career development seminars, journal clubs, Training the Trainers workshops, and grant writing workshops. Each year trainees will be expected to present their research at the annual Markesbery Symposium on Aging and Dementia. Postdoctoral trainees will be provided with additional training opportunities, including: 1) a short off-site externship at another laboratory that conducts Alzheimer's disease research and 2) presentations at the annual College of Medicine Postdoctoral Poster Session. Quantitative and qualitative metrics for evaluation of trainees and the training program will assure a high-quality and effective training experience. The outcomes of our program are intended to nurture highly innovative, well-trained scholars who are dedicated and passionate about finding new approaches to prevent or slow Alzheimer's disease and related dementias.

7.项目总结/摘要 这是一份T32培训补助金的申请，标题是“阿尔茨海默病转化研究培训 和相关痴呆症（TRIAD）”，以支持4名博士前和4名博士后研究员。的总体目标 拟议的计划是提供跨学科的培训，从板凳到床边，以产生一个新的 翻译的劳动力，这是迫切需要开发和推进有效的治疗阿尔茨海默氏症 疾病和相关的痴呆症。学员将接受严谨和创新的转化研究教育 通过3个集群的多学科和综合指导计划进行培训， 分子/生物化学方法、临床前转化方法和临床研究的连续体。的 主题重点是阿尔茨海默病和相关痴呆症的风险因素;这些风险因素包括 脑血管疾病、神经炎症、唐氏综合征和创伤性脑损伤。培训计划 拥有18名教师导师，他们建立了广泛的互动和合作，并成功地跟踪 训练中的记录。教师导师涵盖了从细胞和分子生物学， 遗传学和数据科学，通过临床前模型系统，治疗开发，神经成像， 神经病理学、临床试验和纵向临床研究。这些导师中的大多数（13） 在肯塔基州桑德斯布朗大学老龄化中心，其中包括一个长期的国家情报局资助的 阿尔茨海默病中心所有在一个中心的主要任命教师也有学术 在肯塔基州大学的其他基础科学或临床部门的任命。博士前实习生 将从我们的综合生物医学科学研究生课程和医学博士/博士课程中招募， 医学院和博士后培训人员通过有针对性的广告和推荐，从 同事和其他阿尔茨海默病中心。除了他们的个性化研究计划和 职业发展计划，每组学员将参加一系列的教育经验， 包括专门AD 101阿尔茨海默病和相关痴呆症课程， 研究和临床伦理，每月的研究和职业发展研讨会，期刊俱乐部，培训 培训员讲习班和赠款写作讲习班。每年，学员们都将展示他们的 Markesbery Symposium on Aging and Dementia（Markesbery老年痴呆研讨会）将提供博士后培训生 额外的培训机会，包括：1）在另一个实验室进行短期的场外实习， 阿兹海默症的研究和2）在每年的医学院博士后海报上的演讲 上网时段评估受训人员和培训计划的定量和定性指标将确保 高质量和有效的培训经验。我们计划的成果旨在培养高度 创新，训练有素的学者谁是专门和热情寻找新的方法，以防止 或慢性阿尔茨海默氏症和相关痴呆症。