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Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病及相关痴呆症转化研究培训 (TRIAD)

基本信息

批准号：
10212210
负责人：
Michael Paul Murphy
金额：
$ 49.89万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10212210
关键词：
Alzheimer&apos s disease related dementia Training Translational Research

项目摘要

7. PROJECT SUMMARY/ABSTRACT This is an application for a T32 training grant titled “Training in Translational Research in Alzheimer's Disease and Related Dementias (TRIAD)” to support 4 predoctoral and 4 postdoctoral fellows. The overall goal of the proposed program is to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to develop and advance effective treatments for Alzheimer's disease and related dementias. Trainees will receive rigorous and innovative translational research education and training through a 3-cluster multidisciplinary and integrative mentoring program that spans the discovery continuum from molecular/biochemical methods, preclinical translational approaches and clinical research. The thematic focus is on risk factors for Alzheimer's disease and related dementias; these risk factors include cerebrovascular disease, neuroinflammation, Down syndrome, and traumatic brain injury. The training program has 18 faculty mentors with established and extensive interactions and collaborations, and successful track records in training. The faculty mentors encompass diverse areas of expertise from cell & molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, neuropathology, clinical trials, and longitudinal clinical studies. The majority (13) of these mentors are housed within the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer's Disease Center. All faculty with primary appointments in a Center also have academic appointments in other basic science or clinical departments at the University of Kentucky. Predoctoral trainees will be recruited from our Integrated Biomedical Sciences graduate program and from the MD/PhD program in the College of Medicine, and postdoctoral trainees through targeted advertisement and recommendations from colleagues and other Alzheimer's Disease Centers. In addition to their individualized research program and career development plan, each group of trainees will participate in a series of educational experiences that include a dedicated AD101 course in Alzheimer's disease and related dementias, seminars describing research and clinic ethics, monthly research and career development seminars, journal clubs, Training the Trainers workshops, and grant writing workshops. Each year trainees will be expected to present their research at the annual Markesbery Symposium on Aging and Dementia. Postdoctoral trainees will be provided with additional training opportunities, including: 1) a short off-site externship at another laboratory that conducts Alzheimer's disease research and 2) presentations at the annual College of Medicine Postdoctoral Poster Session. Quantitative and qualitative metrics for evaluation of trainees and the training program will assure a high-quality and effective training experience. The outcomes of our program are intended to nurture highly innovative, well-trained scholars who are dedicated and passionate about finding new approaches to prevent or slow Alzheimer's disease and related dementias.

7.项目摘要/摘要这是一份T32培训基金的申请书，标题为“阿尔茨海默病的翻译研究培训” 以及相关的痴呆症(三合会)“，以支助4名博士后研究员和4名博士后研究员。该计划的总体目标拟议的计划是提供从板凳到床边的跨学科培训，以产生新的开发和推进阿尔茨海默氏症有效治疗方法急需的翻译劳动力疾病和相关痴呆症。学员将接受严谨和创新的翻译研究教育并通过跨发现的3群集多学科综合指导计划进行培训来自分子/生化方法、临床前转化方法和临床研究的连续体。这个主题重点是阿尔茨海默病和相关痴呆症的风险因素；这些风险因素包括脑血管疾病、神经炎症、唐氏综合症和创伤性脑损伤。培训计划拥有18名教师导师，具有成熟和广泛的互动和协作关系，并取得成功训练中的记录。教师导师涵盖了细胞和分子生物学的不同专业领域，遗传学和数据科学，通过临床前模型系统、治疗开发、神经成像、神经病理学、临床试验和纵向临床研究。这些导师中的大多数(13人)都住在在肯塔基大学桑德斯·布朗老龄化中心内，其中包括一个由NIA资助的长期项目阿尔茨海默氏症中心。所有在中心担任主要职务的教职员工也都有学术肯塔基大学其他基础科学或临床系的预约。博士前实习生将从我们的综合生物医学研究生项目和博士/博士项目中招聘医学院和博士后实习生通过有针对性的广告和来自同事和其他阿尔茨海默氏症中心。除了他们的个性化研究计划和职业发展计划，每组学员将参加一系列的教育经历，包括关于阿尔茨海默病和相关痴呆症专门AD101课程、描述研究和临床伦理，每月研究和职业发展研讨会，杂志俱乐部，培训培训员讲习班和赠款撰写讲习班。每年受训者将被要求展示他们的在一年一度的马克斯贝里衰老和痴呆症研讨会上进行的研究。将提供博士后实习生有更多的培训机会，包括：1)在另一个实验室进行短期的异地实习阿尔茨海默病研究和在医学院年度博士后海报上的演讲会议。评估受训人员和培训计划的定量和定性指标将确保优质有效的培训体验。我们计划的结果是要高度培育创新、训练有素的学者，致力于寻找新的预防方法或慢性阿尔茨海默病和相关痴呆症。