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Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病及相关痴呆症转化研究培训 (TRIAD)

基本信息

批准号：
10212210
负责人：
Michael Paul Murphy
金额：
$ 49.89万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10212210
关键词：
Alzheimer&apos s disease related dementia Training Translational Research

项目摘要

7. PROJECT SUMMARY/ABSTRACT This is an application for a T32 training grant titled “Training in Translational Research in Alzheimer's Disease and Related Dementias (TRIAD)” to support 4 predoctoral and 4 postdoctoral fellows. The overall goal of the proposed program is to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to develop and advance effective treatments for Alzheimer's disease and related dementias. Trainees will receive rigorous and innovative translational research education and training through a 3-cluster multidisciplinary and integrative mentoring program that spans the discovery continuum from molecular/biochemical methods, preclinical translational approaches and clinical research. The thematic focus is on risk factors for Alzheimer's disease and related dementias; these risk factors include cerebrovascular disease, neuroinflammation, Down syndrome, and traumatic brain injury. The training program has 18 faculty mentors with established and extensive interactions and collaborations, and successful track records in training. The faculty mentors encompass diverse areas of expertise from cell & molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, neuropathology, clinical trials, and longitudinal clinical studies. The majority (13) of these mentors are housed within the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer's Disease Center. All faculty with primary appointments in a Center also have academic appointments in other basic science or clinical departments at the University of Kentucky. Predoctoral trainees will be recruited from our Integrated Biomedical Sciences graduate program and from the MD/PhD program in the College of Medicine, and postdoctoral trainees through targeted advertisement and recommendations from colleagues and other Alzheimer's Disease Centers. In addition to their individualized research program and career development plan, each group of trainees will participate in a series of educational experiences that include a dedicated AD101 course in Alzheimer's disease and related dementias, seminars describing research and clinic ethics, monthly research and career development seminars, journal clubs, Training the Trainers workshops, and grant writing workshops. Each year trainees will be expected to present their research at the annual Markesbery Symposium on Aging and Dementia. Postdoctoral trainees will be provided with additional training opportunities, including: 1) a short off-site externship at another laboratory that conducts Alzheimer's disease research and 2) presentations at the annual College of Medicine Postdoctoral Poster Session. Quantitative and qualitative metrics for evaluation of trainees and the training program will assure a high-quality and effective training experience. The outcomes of our program are intended to nurture highly innovative, well-trained scholars who are dedicated and passionate about finding new approaches to prevent or slow Alzheimer's disease and related dementias.

7. 项目概要/摘要这是一份名为“阿尔茨海默病转化研究培训”的 T32 培训补助金申请和相关痴呆症（TRIAD）”，以支持 4 名博士前研究员和 4 名博士后研究员。该项目的总体目标拟议的计划是提供从实验室到临床的跨学科培训，以产生新的开发和推进阿尔茨海默病的有效治疗方法急需转化型劳动力疾病和相关的痴呆症。学员将接受严格和创新的转化研究教育并通过涵盖发现的 3 集群多学科和综合指导计划进行培训分子/生化方法、临床前转化方法和临床研究的连续体。这主题重点是阿尔茨海默病和相关痴呆症的危险因素；这些风险因素包括脑血管疾病、神经炎症、唐氏综合症和创伤性脑损伤。培训计划拥有 18 名导师，拥有广泛的互动和合作，并取得了成功的轨迹训练中的记录。教师导师涵盖细胞和分子生物学的各个专业领域，遗传学和数据科学，通过临床前模型系统、治疗开发、神经影像学、神经病理学、临床试验和纵向临床研究。这些导师中的大多数 (13) 都居住在位于肯塔基大学桑德斯·布朗老龄化中心，其中包括一个由 NIA 资助的长期研究中心阿尔茨海默病中心。所有在中心担任主要职务的教员也有学术资格肯塔基大学其他基础科学或临床部门的任命。博士前培训生将从我们的综合生物医学科学研究生项目和医学博士/博士项目中招募通过有针对性的广告和推荐，医学院和博士后学员同事和其他阿尔茨海默病中心。除了他们的个性化研究计划和职业发展计划中，每组学员都会参加一系列的教育体验，包括关于阿尔茨海默病和相关痴呆症的专门 AD101 课程，研讨会描述了研究和临床道德、每月研究和职业发展研讨会、期刊俱乐部、培训培训师研讨会和拨款写作研讨会。每年，学员都将展示他们的成果年度马克斯伯里老龄化和痴呆症研讨会上的研究。将提供博士后实习生提供额外的培训机会，包括：1）在另一个进行短期异地实习的实验室阿尔茨海默病研究和 2) 在年度医学院博士后海报上的演讲会议。用于评估学员和培训计划的定量和定性指标将确保高质量、有效的培训体验。我们计划的成果旨在培养高度富有创新精神、训练有素的学者，他们热衷于寻找新的方法来预防或减缓阿尔茨海默病和相关痴呆症。