Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)

阿尔茨海默病及相关痴呆症转化研究培训 (TRIAD)

基本信息

批准号：
10672322
负责人：
Michael Paul Murphy
金额：
$ 52.44万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10672322
关键词：
Alzheimer&apos s disease related dementia Training Translational Research

项目摘要

ABSTRACT Our T32 training program entitled “Training in Translational Research In Alzheimer’s and Related Dementias (TRIAD)” aims to provide cross-disciplinary training from bench to bedside, to produce a new translational workforce that is critically needed to advance effective treatments for Alzheimer’s disease and related dementias (ADRD). We will continue to support 4 predoctoral and 4 postdoctoral trainees who will receive rigorous training through a transdisciplinary and integrative mentoring program that spans the discovery continuum from molecular/ biochemical methods, preclinical translational approaches, and clinical research. The thematic focus is on major ADRD risk factors, including cerebrovascular dysfunction, neuroinflammation, brain injury, and genetic/lifestyle risks. The 23 faculty mentors include well-funded investigators with established and extensive collaborative relationships and successful track records in training. The faculty mentors encompass diverse yet complementary areas of expertise along the translational continuum from cell and molecular biology, genetics, and data science, through preclinical model systems, therapeutic development, neuroimaging, biomarkers, neuropathology, clinical trials, and longitudinal clinical studies. The majority (20) of these mentors are faculty in the University of Kentucky Sanders Brown Center on Aging, which includes a long-standing NIA-funded Alzheimer’s Disease Research Center (ADRC). The two-year training plan will emphasize 1) experiential research and learning of core competencies required to become independent leaders in clinical/ translational research, 2) a tailored educational plan that emphasizes the translational continuum from basic science to clinical to community, and 3) multidisciplinary mentoring from highly committed program faculty. Each trainee will develop an individualized development plan to enable advancement to independent research and funding. Trainees will participate in a structured educational program that includes a dedicated AD101 course, training in the responsible conduct of research, Good Research Practice training, data science, and workshops and seminars. Trainees will gain career development experiences through the monthly trainee-organized team meeting, presentations at the annual Markesbery Symposium on Aging and Dementia, and grant writing workshops. Trainees will also have the opportunity to participate in an experiential learning externship, which can include an off-site training course, visiting a collaborator’s lab to develop additional research skills, or visiting another ADRC to observe/shadow/learn specific aspects based on the trainee’s research interests. Quantitative and qualitative metrics for evaluation of trainees, mentors, and the training program will assure a high-quality and effective training experience. Overall, this T32 program is uniquely positioned to fill a growing need for a diverse, translational research workforce with the cross-disciplinary team science skills required to conduct rigorous and cutting-edge basic, translational, and clinical research to develop and advance effective interventions for ADRD.

抽象的我们的T32培训计划题为“阿尔茨海默氏症和相关痴呆症的翻译研究培训（三合会）”旨在提供从长凳到床边的跨学科培训，以产生新的翻译迫切需要为阿尔茨海默氏病和相关的有效治疗而迫切需要的劳动力痴呆症（ADRD）。我们将继续支持4位将获得的4个毒品和4位博士后学员通过跨学科和综合心理计划进行严格的培训，该计划跨越发现分子/生化方法，临床前翻译方法和临床研究的连续体。主题重点是主要的ADRD危险因素，包括脑血管功能障碍，神经炎症，脑损伤和遗传/生活方式风险。 23位教职导师包括资助良好的调查员建立了广泛的合作关系和培训中的成功记录。教师导师涵盖了潜水员，但沿细胞的翻译连续体的专业知识领域以及分子生物学，遗传学和数据科学，通过临床前模型系统，治疗发育，神经影像学，生物标志物，神经病理学，临床试验和纵向临床研究。这些导师中的大多数是肯塔基大学桑德斯·布朗大学老龄化中心的教师，包括长期以来由NIA资助的阿尔茨海默氏病研究中心（ADRC）。为期两年的培训计划将强调1）专家研究和学习所需的核心能力临床/翻译研究领域的独立领导者，2）一个量身定制的教育计划，强调从基础科学到临床到社区的转化连续性，以及3）多学科的指导高度致力于计划的教师。每个学员将制定一个个性化的发展计划，以实现独立研究和资金的进步。学员将参加结构化教育计划包括专门的AD101课程，负责任的研究培训，良好研究实践培训，数据科学以及研讨会和下水道。学员将获得职业发展通过每月通过学员组织的团队会议的经验，在年度Markesbery举行的演讲衰老和痴呆症研讨会，并授予写作讲习班。学员也将有机会参加专家学习的实习，其中可能包括场外培训课程，参观合作者的实验室，以开发其他研究技能，或访问另一个ADRC来观察/阴影/学习基于学员的研究兴趣的特定方面。定量和定性指标用于评估学员，导师和培训计划将具有高质量和有效的培训经验。全面的，该T32计划的独特位置可以满足对潜水员翻译的研究人员的日益增长的需求凭借进行严格而尖端的基础所需的跨学科团队科学技能，转化和临床研究，以开发和推进ADRD的有效干预措施。