BRAIN HEALTH TOGETHER: A LIVE-STREAMING GROUP-BASED DIGITAL PROGRAM

Together High Health，Inc.(Together)是一家由女性拥有的小企业，致力于帮助 认知功能减退或阿尔茨海默病及相关痴呆(ADRD)的老年人维持生活质量 通过提供创新的、以证据为基础的、在线的、实时的、团体节目。我们的第一次 Together音频/视频平台上的产品是Moving TogetherTM-它将运动结合到 通过正念的身体意识练习和社交活动支持日常功能，旨在 患有轻度ADRD的人和他们的照顾者在家一起参与。这样做的主要目标是 第二阶段小型企业创新研究(SBIR)资助是为了通过开发 并为轻度认知障碍患者测试一项全面的大脑健康共同计划 损害(MCI)。这一目标对我们公司来说是至关重要的下一步 健康和商业视角。患有MCI的老年人代表着一个巨大的市场，有着重要的未得到满足的需求： 大约20%的老年人(270万美国人)目前患有MCI，这使他们处于 发展成ADRD的风险增加。目前还没有药物可以阻止ADRD的发展 患有MCI的人；然而，越来越多的证据表明，针对目标的行为干预是可以改变的 痴呆症的危险因素--如缺乏运动、与世隔绝和抑郁--可能有助于改善 认知功能，并有可能延缓痴呆的发病。我们的初步结果表明，我们的产品， 同居与认知功能、身体功能、社交能力的显著改善有关 隔离、自我调节以及增加休眠前/休眠后的默认模式网络连接 功能性磁共振成像(rs-fmri)在mci患者中进行扫描。我们相信，这些好处 如果一起行动与全面的大脑健康指导相结合，那就更好了 程序。因此，我们的具体目标是：1)与我们的科学顾问委员会合作并使用 以人为中心的设计，为大脑健康共同开发基于证据的内容，为期12周，以小组为基础， 直播，这是一项数字计划，将与大脑健康指导相结合，以解决 MCI患者的可调性痴呆症危险因素；2)进行随机对照试验以确定 大脑健康共同计划是否改善了12周以上MCI患者的认知功能 与成功老化的对照组进行比较；以及3)确定每周的维持课 有助于在干预后12周内维持大脑健康共同计划的效果。如果我们可以 证明大脑健康在以下方面具有直接和持久的认知益处 MCI患者，它将共同定位为循证项目的全国领导者 改善老年人的生活质量，防止认知障碍的下降。

Together Senior Health, Inc. (TOGETHER) is a woman-owned small business that is dedicated to helping older adults with cognitive decline or Alzheimer’s disease and related dementias (ADRD) maintain quality of life and independence by offering innovative, evidence-based, online, livestream, group programs. Our first product on the TOGETHER audio/video platform is Moving TogetherTM—which combines movements to support daily function with mindful body awareness exercises and social engagement and is designed for people with mild ADRD and their caregivers who participate together from home. The primary goal of this Phase II Small Business Innovation Research (SBIR) grant is to expand our product line by developing and testing a comprehensive BRAIN HEALTH TOGETHER program for people living with mild cognitive impairment (MCI). This goal represents a critically important next step for our company from both public health and business perspectives. Older adults with MCI represent a large market with important unmet needs: approximately 20% of older adults (>2.7 million Americans) are currently living with MCI, which places them at increased risk of developing ADRD. There are no medications that can prevent development of ADRD in people with MCI; however, there is growing evidence that behavioral interventions targeting modifiable dementia risk factors—such as physical inactivity, social isolation, and depression—may help improve cognitive function and could potentially delay dementia onset. Our preliminary results suggest that our product, Moving Together is associated with significant improvements in cognitive function, physical function, social isolation, and self-regulation as well as increased default mode network connectivity on pre/post resting state functional magnetic resonance imaging (rs-fMRI) scans in people with MCI. We believe that these benefits would be even greater if Moving Together were combined with a comprehensive brain health coaching program. Therefore, our Specific Aims are to: 1) Work with our Scientific Advisory Board and use humancentered design to develop evidence-based content for Brain Health Together, a 12-week, group-based, livestreaming, digital program that will combine Moving Together with brain health coaching to address modifiable dementia risk factors in people with MCI; 2) Perform a randomized, controlled trial to determine whether the Brain Health Together program improves cognitive function in people with MCI over 12 weeks compared to a Successful Aging comparison group; and 3) Determine whether weekly maintenance classes help to sustain the effects of the Brain Health Together program over 12 weeks after the intervention. If we can demonstrate that BRAIN HEALTH TOGETHER has immediate and sustained cognitive benefits in people with MCI, it will position TOGETHER as a national leader in evidence-based programs to improve quality of life and prevent decline in older adults with cognitive impairment.